Patents Assigned to NeuroMolecular, Inc.
  • Antioxidant nitroxides and nitrones as therapeutic agents
    Patent number: 6852889
    Abstract: The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate; R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R9-R14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: January 30, 2004
    Date of Patent: February 8, 2005
    Assignees: Panorama Research, Inc., NeuroMolecular, Inc.
    Inventors: Yuqiang Wang, James W. Larrick
  • Antioxidant nitroxides and nitrones as therapeutic agents
    Patent number: 6717012
    Abstract: The invention provides novel adamantane compounds having one of the following formulas: wherein: R1 and R3 are H, OH, alkyl, cycloalkyl, amino or aryl, and can be the same or different; R2 is H, NH2, alkyl, OH, COOH, amino, amide, or carbamate; R4-R8 are H, OH, NH2, alkyl, OH, COOH, ester, amino, amide, or alkyloxy, and can be the same or different; R9-R14 are H, alkyl, or phenyl, and can be the same or different; and wherein when any of R1-R8 is amino, the compounds are the free bases and their acid addition salts. The present invention also relates to compositions and methods for treating and/or preventing neurological and inflammatory disorders in a patient by administering a therapeutically effective amount of the compounds of formula (I), (II) or (III) and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: April 6, 2004
    Assignee: NeuroMolecular, Inc.
    Inventors: Yuqiang Wang, James W. Larrick
  • Aminoadamantane derivatives as therapeutic agents
    Patent number: 6620845
    Abstract: The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions.
    Type: Grant
    Filed: July 19, 2002
    Date of Patent: September 16, 2003
    Assignee: NeuroMolecular, Inc.
    Inventors: Yuqiang Wang, Wenqing Ye, James W. Larrick, Jonathan S. Stemler, Stuart A. Lipton
  • Atypical antipsychotic agents having low affinity for the D2 Receptor
    Publication number: 20030135042
    Abstract: The present invention provides novel compounds of Formula I: 1
    Type: Application
    Filed: June 25, 2002
    Publication date: July 17, 2003
    Applicant: NeuroMolecular, Inc.
    Inventors: Shitij Kapur, Robert McClelland
  • Aminoadamantane derivatives as therapeutic agents
    Patent number: 6444702
    Abstract: The present invention provides novel aminoadamantane derivatives, methods of making the derivatives, compositions including the novel aminoadamantane derivatives, and methods for the treatment and prevention of neurological diseases using the derivatives and compositions.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: September 3, 2002
    Assignee: NeuroMolecular, Inc.
    Inventors: Yuqiang Wang, Wenqing Ye, James W. Larrick, Jonathan S. Stemler, Stuart A. Lipton