Patents Assigned to NeuroNova AB
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Patent number: 8318704Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells via S1P or LPA signaling. These methods are useful for reducing at least one symptom of the disorder.Type: GrantFiled: August 31, 2010Date of Patent: November 27, 2012Assignee: NeuroNova ABInventors: Per Lindquist, Alex Mercer, Harriet Rönnholm, Lilian Wikström
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Publication number: 20120077741Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.Type: ApplicationFiled: June 14, 2011Publication date: March 29, 2012Applicant: NeuroNova ABInventors: Kioumars Delfani, Ann Marie Janson, H. Georg Kuhn, Karlheinz Plate, Anne Schanzer, Frank-Peter Wachs, Ming Zhao
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Publication number: 20110189184Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells via S1P or LPA signaling. These methods are useful for reducing at least one symptom of the disorder.Type: ApplicationFiled: August 31, 2010Publication date: August 4, 2011Applicant: NeuroNova ABInventors: Per Lindquist, Alex Mercer, Harriet Rönnholm, Lilian Wikström
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Patent number: 7981863Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells. These methods are useful for reducing at least one symptom of the disorder.Type: GrantFiled: September 18, 2002Date of Patent: July 19, 2011Assignee: Neuronova ABInventors: Kioumars Delfani, Ann Marie Janson, H. Georg Kuhn, Karlheinz Plate, Anne Schanzer, Frank-Peter Wachs, Ming Zhao
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Patent number: 7811822Abstract: The invention relates generally to methods of influencing central nervous system cells to produce progeny useful in the treatment of CNS disorders. More specifically, the invention includes methods of exposing a patient suffering from such a disorder to a reagent that modulates the proliferation, migration, differentiation and survival of central nervous system cells via S1P or LPA signaling. These methods are useful for reducing at least one symptom of the disorder.Type: GrantFiled: July 19, 2007Date of Patent: October 12, 2010Assignee: NeuroNova ABInventors: Per Lindquist, Alex Mercer, Harriet Rönnholm, Lilian Wikström
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Patent number: 7320872Abstract: The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.Type: GrantFiled: June 27, 2002Date of Patent: January 22, 2008Assignee: NeuroNova ABInventors: Ann Marie Janson, Jonas Frisen, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, Kioumars Delfani
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Patent number: 7279332Abstract: The present invention relates to a method of determining whether a test compound is a proliferation-inducing or proliferation-inhibiting agent of ependymal neural stem cells. The method comprises: (a) contacting an ependymal neural stem cell with the test compound: and (b) determining the proliferation of the ependymal neural stem cell, wherein if the proliferation of the ependymal neural stem cell is increased in the presence of the test compound as compared to the absence of the test compound, the test compound is identified as a proliferation-inducing agent or wherein if the proliferation of the ependymal neural stem cell is decreased in the presence of the test compound as compared to the absence of the test compound, the test compound is identified as a proliferation-inhibiting agent.Type: GrantFiled: December 20, 2002Date of Patent: October 9, 2007Assignee: NeuroNova ABInventors: Jonas Frisén, Ann Marie Janson, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, Kioumars Delfani
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Patent number: 6969702Abstract: The invention is directed to methods of promoting neurogenesis by contacting neuronal tissue with neurogenesis increasing agents. Novel methods for treating neurological disorders using neurogenesis increasing agents are disclosed.Type: GrantFiled: May 19, 2004Date of Patent: November 29, 2005Assignee: NeuroNova ABInventors: Göran Bertilsson, Rikard Erlandsson, Jonas Frisen, Anders Haegerstrand, Jessica Heidrich, Nina Hellström, Johan Häggblad, Katarina Jansson, Jarkko Kortesmaa, Per Lindquist, Hanna Lundh, Jacqueline McGuire, Alex Mercer, Karl Nyberg, Amina Ossoinak, Cesare Patrone, Harriet Rönnholm, Lilian Wikström, Olof Zachrisson
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Publication number: 20030092176Abstract: The invention relates to an ependymal neural CNS stem cell, which cell expresses the surface protein Notch 1 together with at least one surface protein chosen from the group of Notch 2, Notch 3, CAR (transmembrane protein binding adenovirus) and CFTR cystic fibrosis transmembrane conductance regulator), and which cell also comprises at least one cilium. The invention also relates to preparations, including pharmaceutical preparations, comprising ependymal neural CNS stem cells, in vitro and in vivo assays based thereon and various other uses of the novel ependymal cells according to the invention.Type: ApplicationFiled: June 27, 2002Publication date: May 15, 2003Applicant: NeuroNova ABInventors: Ann Marie Janson, Jonas Frisen, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, Kioumars Delfani
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Patent number: 6541247Abstract: The present invention relates to a method of isolating ependymal neural CNS stem cells from a post-natal animal or a human, which method comprises the steps of (a) screening single cells obtained by dissociating CNS tissue from said animal for cells exhibiting at least one characteristic of an ependymal neural stem cell; and (b) recovering the cells that exhibit the characteristic or characteristics screened for in step (a). The screening may be performed for a specific cell surface protein or by previously labeling the ependymal cells. The invention also relates to isolated ependymal neural CNS stem cells, in vitro and in vivo assays based on the findings according to the invention and various uses of the ependymal neural stem cells according to the invention.Type: GrantFiled: June 25, 1998Date of Patent: April 1, 2003Assignee: Neuronova ABInventors: Jonas Frisën, Ann Marie Janson, Clas Johansson, Stefan Momma, Diana Clarke, Ming Zhao, Urban Lendahl, Kioumars Delfani