Patents Assigned to New Health Sciences, Inc.
-
Patent number: 9844615Abstract: A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.Type: GrantFiled: October 27, 2015Date of Patent: December 19, 2017Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul Vernucci
-
Patent number: 9801784Abstract: A blood storage container for the anaerobic storage of blood, having enhanced sealing methods and materials for the preservation of stored blood is provided.Type: GrantFiled: March 31, 2017Date of Patent: October 31, 2017Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Rafael Cordero, Jancarlo Sarita, Michael Zocchi, Michael Wolf, Philip Michael Keegan, Narendran Renganathan, Jeffrey Karl Sutton
-
Publication number: 20170072339Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.Type: ApplicationFiled: November 29, 2016Publication date: March 16, 2017Applicant: New Health Sciences, Inc.Inventors: Tatsuro YOSHIDA, Paul J. VERNUCCI
-
Patent number: 9539375Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.Type: GrantFiled: March 2, 2015Date of Patent: January 10, 2017Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci
-
Publication number: 20160219868Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.Type: ApplicationFiled: April 11, 2016Publication date: August 4, 2016Applicants: New Health Sciences, Inc., Trustees of Dartmouth CollegeInventors: Larry J. DUMONT, Tatsuro YOSHIDA
-
Patent number: 9339025Abstract: The present invention is a method for enhancing the quality and survival of red blood cells during storage by depleting the red blood cells of both carbon dioxide and oxygen and maintaining 2,3-diphosphoglycerate acid levels.Type: GrantFiled: August 25, 2011Date of Patent: May 17, 2016Assignees: New Health Sciences, Inc., Trustees of Dartmouth CollegeInventors: Tatsuro Yoshida, Larry J. Dumont
-
Patent number: 9296990Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: GrantFiled: September 26, 2013Date of Patent: March 29, 2016Assignees: New Health Sciences, Inc., University of Pittsburgh-of the Commonwealth System of Higher EducationInventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci
-
Publication number: 20160045650Abstract: A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.Type: ApplicationFiled: October 27, 2015Publication date: February 18, 2016Applicant: NEW HEALTH SCIENCES, INC.Inventors: Tatsuro YOSHIDA, Paul VERNUCCI
-
Publication number: 20160007588Abstract: Devices for the preparation of depleted blood products that provide for the depletion of oxygen, carbon dioxide, or oxygen and carbon dioxide are described. In addition, devices for the replenishment of oxygen and other gases to an anaerobic blood product are described. Methods and systems incorporating depletion and addition devices are provided to optimize the preparation, storage and transfusion of blood products to a recipient are described.Type: ApplicationFiled: February 28, 2014Publication date: January 14, 2016Applicant: NEW HEALTH SCIENCES, INC.Inventors: Steven F. LEVESQUE, Thomas R RUTH
-
Patent number: 9199016Abstract: A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described.Type: GrantFiled: July 3, 2012Date of Patent: December 1, 2015Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul Vernucci
-
BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES
Publication number: 20150284682Abstract: A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.Type: ApplicationFiled: June 22, 2015Publication date: October 8, 2015Applicant: NEW HEALTH SCIENCES, INC.Inventors: Tatsuro YOSHIDA, Paul J. VERNUCCI -
Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities
Patent number: 9095662Abstract: A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.Type: GrantFiled: August 16, 2013Date of Patent: August 4, 2015Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J Vernucci -
Patent number: 9067004Abstract: A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device. The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.Type: GrantFiled: March 28, 2012Date of Patent: June 30, 2015Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul Vernucci
-
Publication number: 20150165102Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.Type: ApplicationFiled: March 2, 2015Publication date: June 18, 2015Applicant: NEW HEALTH SCIENCES, INC.Inventors: Tatsuro YOSHIDA, Paul J. VERNUCCI
-
Publication number: 20150153367Abstract: Artificial microvascular network (AMVN) devices are provided and related methods of making and methods of using such devices are provided. The present disclosure generally relates to an AMVN device comprising a substrate including a capillary network configured so as to simulate those actually encountered in the circulation of various humans and animal model systems. In certain aspects, the AMVN devices may be used, e.g., to investigate the effect of storing RBCs under aerobic and anaerobic conditions. However, the use of such AMVN devices is not so limited.Type: ApplicationFiled: May 22, 2013Publication date: June 4, 2015Applicants: The Administrators of the Tulane Educational Fund, New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Sergey S. Shevkoplyas, Jennie M. Burns
-
Publication number: 20150147744Abstract: A portable assembly for processing red blood cells RBCs including a disposable blood collection set including a blood bag, an anaerobic storage bag and an oxygen and/or oxygen and carbon dioxide depletion device disposed between the blood collection bag and anaerobic storage bag. The portable assembly further provides for a gas circulation device in fluid communication with the oxygen or oxygen and carbon dioxide depletion device, The gas circulation device includes a pressure source that is able circulate flushing gas through the depletion device as RBCs pass from the blood collection bag, through the depletion device and into the anaerobic storage bag.Type: ApplicationFiled: February 4, 2015Publication date: May 28, 2015Applicant: NEW HEALTH SCIENCES, INC.Inventors: Tatsuro YOSHIDA, Paul VERNUCCI
-
Patent number: 9005343Abstract: A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.Type: GrantFiled: August 10, 2012Date of Patent: April 14, 2015Assignee: New Health Sciences, Inc.Inventors: Tatsuro Yoshida, Paul J. Vernucci
-
Publication number: 20140030694Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: ApplicationFiled: September 26, 2013Publication date: January 30, 2014Applicants: University of Pittsburgh - Of the Commonwealth System of Higher Education, New Health Sciences, Inc.Inventors: William J. FEDERSPIEL, Brian J. FRANKOWSKI, Tatsuro YOSHIDA, Paul J. VERNUCCI
-
BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES
Publication number: 20130333561Abstract: A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.Type: ApplicationFiled: August 16, 2013Publication date: December 19, 2013Applicant: New Health Sciences, Inc.Inventors: Tatsuro YOSHIDA, Paul J. Vernucci -
Patent number: 8569052Abstract: An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.Type: GrantFiled: May 25, 2011Date of Patent: October 29, 2013Assignees: New Health Sciences, Inc., University of Pittsburgh-Of the Commonwealth System of Higher EducationInventors: William J. Federspiel, Brian J. Frankowski, Tatsuro Yoshida, Paul J. Vernucci