Abstract: Provided herein are compositions and methods that inhibit expression of Adam9 gene products, such as ADAM9 mRNA and/or ADAM9 polypeptides, as a therapeutic approach for the treatment of pathological neovascularization and conditions associated with angiogenesis.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.

Abstract: The present invention relates to methods for identifying tissue sites in a chronic wound that are suitable for debridement and whether debridement procedure has been successful using particular biological markers of the cells within the tissue sites of the chronic wounds.

Abstract: This invention relates to BMP fusion genes, BMP fusion proteins, and methods for making BMP fusion genes and BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.

Abstract: An implant system and apparatus configured to permit motion of the wrist in at least one physiological direction, as well as in a dart thrower's motion, and constrain motion of the wrist in at least one non-physiological direction are provided. The implant according to one embodiment includes a distal component and proximal component. Each of the distal and proximal components includes a primary articulating portion and a secondary articulating portion. Primary and secondary articulating portions include at least one component having either a substantially convex or a substantially concave shape. The secondary articulating portion is configured to be radially and volarly disposed in relation to the primary articulating portion.

Abstract: A surgical device for use in attaching a first member (e.g., soft-tissue) to a second member (e.g., a bone) includes a suture anchor that has a body having a first end; a pointed tip at an opposite second end; and a contoured outer surface. An anchor head that is coupled to the body at the first end has an opening to permit attachment of one or more suture to the body. The suture anchor also includes a reservoir formed in the body and being open at the first end thereof and closed at an opposite end. The reservoir is configured to store and release at least one of a drug, a therapeutic agent, a growth factor, or a combination thereof from a top surface of the anchor body into a site of an interface between the first and second members to promote healing or therebetween or limit post-operative pain.

Abstract: The present invention relates to methods for identifying patients that will respond to treatment with anti-TNF-therapy, i.e., anti-TNF responder patients. In particular, the present invention relates to determining response to an inhibitor of tumor necrosis factor (TNF) in a patient with a chronic inflammatory disease by determining the activity of type I interferon in the patient. The invention further relates to quantification of type I interferon as a measure of predicting responsiveness to anti-TNF therapy in patients with a chronic inflammatory disease such as rheumatoid arthritis (RA), psoriatic arthritis, ankylosing spondylitis, juvenile chronic arthritis, lupus, Crohn's disease, as well as for cardiovascular disease.

Abstract: The present invention relates to methods and compositions that control, i.e., antagonize/inhibit or agonize/stimulate, de novo glucocorticoid production in the skin. Such methods and compositions can be used for the prevention and/or treatment of a variety of skin conditions, including inflammation, acute wounds, chronic non-healing wounds, keloid, fibrotic or hypertrophic scars, and epithelial-derived cancer.

Abstract: This invention relates to BMP fusion genes, BMP fusion proteins. The invention further relates to methods for treatment using BMP fusion genes and BMP fusion proteins. Additionally, the invention relates to BMP fusion gene and BMP fusion protein pharmaceutical compositions.

Abstract: The present invention provides a composition for osteoinduction, which comprises a complexed-acidic-phospholipid complex containing calcium, phospholipid, and inorganic phosphate combined with collagen in a composite form. The composition is effective to promote new bone formation upon introduction of the composition into various osseous defects.

Abstract: Described are methods for treating, preventing, or reducing the risk of, miscarriages, especially recurrent miscarriages. The methods comprise administering to a female subject a therapeutic agent that modulates the activity or binding of components of the complement system, together with a pharmaceutically acceptable carrier. For example, the therapeutic agent can be a C3-convertase inhibitor, an antibody against C5, an antagonist of the C5a receptor, or an antibody against factor B or factor D. Screening methods for agents that can prevent or reduce the risk of miscarriages, especially recurrent miscarriages, are also described.

Abstract: The present invention relates to the field of orthopedics in addressing soft tissue to bone attachment. The embodiments of the present invention provide for a bioabsorbable inlay, a bioabsorbable inlay assembly, and a method to implant the bioabsorbable inlay between soft tissue and bone. Also provided is a means for facilitating soft tissue to bone attachment through the use of a bioabsorbable inlay, bounded with osteoconductive or osteoinductive materials, affixed at the interface of soft tissue to bone attachment sites. In an embodiment, the bioabsorbable inlay is formed into circular discs with holes for sutures to pass through and bounded with hydroxyapatite. The circular discs are then placed in communication between the soft tissue and bone at the appropriate site of attachment through the use of anchors and/or sutures. The bioabsorbable circular disc inlays are either overlaid or recessed into the bone.

Abstract: The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding Fc?RIIB. The invention also provides isolated nucleic acids encoding Fc?RIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.

Abstract: The present invention provides methods for predicting the likelihood of development of systemic lupus erythematosus (SLE) in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding Fc?RIIB. The invention also provides isolated nucleic acids encoding Fc?RIIB polymorphisms, nucleic acid probes that hybridize to polymorphic positions and kits for the prediction of SLE status.

Abstract: The present invention is directed to a method of treating bone length discrepancies and angular deformities in a patient in need thereof, where the method involves radiofrequency ablation epiphysiodesis of a physeal plate. Specifically, the method treats long bone discrepancies with a minimally invasive procedure. The present invention is also directed to a method of inhibiting bone growth, where the method involves exposing a physeal growth plate to radiofrequency ablation epiphysiodesis.

Abstract: The present invention unexpectedly provides a method for treating acute or chronic tendinopathy by transdermal administration of low-dose glyceryl trinitrate, or other nitric oxide-generating agents. The present invention also provides a method of relieving pain caused by tendinopathy by transdermal administration of low-dose glyceryl trinitrate, or other nitric oxide-generating agents.

Abstract: A dual-radius glenoid component of a shoulder joint prosthesis for use in total shoulder arthroplasty has two radii of curvature. At substantially the center of the articulating surface a first non-conforming radius of curvature is provided, while a second conforming radius of curvature, smaller than that of the first radius of curvature and more closely conforming to the curvature of the humeral component, is disposed about the periphery of the articulating surface. The central non-conforming radius of curvature provides reduced constraint of the humeral component. In contrast, the conforming peripheral radius of curvature provides maximum constraint of the humeral component. When the humeral component is substantially centered on the articulating surface reduced constraint is placed on the prosthesis and less load is transferred to the bone-implant interface. As the humeral component translates towards the periphery, constraint on the prosthesis increases to prevent dislocation.

Abstract: A dual-radius glenoid component of a shoulder joint prosthesis for use in total shoulder arthroplasty has two radii of curvature. At substantially the center of the articulating surface a first non-conforming radius of curvature is provided, while a second conforming radius of curvature, smaller than that of the first radius of curvature and more closely conforming to the curvature of the humeral component, is disposed about the periphery of the articulating surface. The central non-conforming radius of curvature provides reduced constraint of the humeral component. In contrast, the conforming peripheral radius of curvature provides maximum constraint of the humeral component. When the humeral component is substantially centered on the articulating surface reduced constraint is placed on the prosthesis and less load is transferred to the bone-implant interface. As the humeral component translates towards the periphery, constraint on the prosthesis increases to prevent dislocation.

Abstract: The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also provided are methods and compositions for inhibiting unwanted wound healing by inhibiting the activity of nitric oxide in the tissue.

Abstract: The present invention provides methods and compositions for promoting healing of damaged tissue that result in an increased level of nitric oxide in the vicinity of the damaged tissue. Also provided are methods and compositions for inhibiting unwanted wound healing by inhibiting the activity of nitric oxide in the tissue.