Patents Assigned to Nirlus Engineering AG
  • Patent number: 11412934
    Abstract: The invention relates to a method of the noninvasive optical in-vivo measurement of properties of flowing blood in a blood vessel within a body, for example for determining the concentration of blood constituents, wherein the body is irradiated with ultrasound radiation at an ultrasound frequency (fUS) in order to label a blood vessel, the body with the blood vessel is illuminated with light with at least one light wavelength and the back-scattered light is detected with a detector, the light component backscattered by the body outside of the blood vessel is modulated by a frequency (fMG) that corresponds to the frequency (fUS) of the ultrasound radiation, and the light component backscattered inside the blood vessel is modulated due to the Doppler effect in flowing blood with a frequency (fMB) that is shifted by the Doppler shift (fD) with respect to the frequency (fUS) of the ultrasound radiation, and an evaluation device extracts the signal component modulated by the shifted frequency (fMB) from the detect
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: August 16, 2022
    Assignee: NIRLUS ENGINEERING AG
    Inventor: Vera Herrmann
  • Patent number: 8426819
    Abstract: Disclosed is a method for the non-invasive optic determination of the temperature of a medium, preferably a water-containing medium, wherein the medium to be analyzed is illuminated by infrared and/or visible light in the region of an absorption line, the position of which depends on the temperature of the medium, and wherein absorption of the light in the region of the absorption line is measured and the temperature is determined from said measurement by comparison with calibration data. Said method is characterized in that the medium is illuminated with at least two discrete light wavelengths (?1, ?2), which are in the region of the absorption line (B) on different sides of the absorption maximum, that at least one measured value (?A/??) dependent on temperature is determined from the relationship of these two determined absorption values to one another, and that the temperature is determined from said measured value by comparison with the previously recorded calibration data.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: April 23, 2013
    Assignee: Nirlus Engineering AG
    Inventor: Vera Herrmann
  • Patent number: 8391939
    Abstract: Method for the continuous measurement of the glucose concentration in blood undergoing pulsational flow, with the steps:—determination of a value for the glucose concentration for a first measurement cycle, and—repetition of the determination of this value in subsequent measurement cycles, where there is multiple detection, within each measurement cycle, of the transmittance and/or scattering power of the blood for at least two incident NIR wavelengths, calculation of an indicator value depending on the blood glucose concentration, and ascertaining the blood glucose concentration by comparing the indicator value with a previously determined calibration table, determination of the blood temperature during the detection of the transmittance and/or scattering power,—continuous measurement of the pulse duration of the pulsational blood flow, where the duration of the measurement cycle is arranged to keep in step as integral multiple of the pulse duration, where the first of the at least two NIR wavelengths is sel
    Type: Grant
    Filed: July 18, 2007
    Date of Patent: March 5, 2013
    Assignee: Nirlus Engineering AG
    Inventor: Vera Herrmann
  • Patent number: 7251518
    Abstract: A method for measuring in non-invasive manner the concentration of blood constituents by which backscattered light is measured under the action of ultrasonic radiation focused towards the inside of a central blood vessel. A light source and detection unit are arranged to detect the backscattered light on the skin surface above the blood vessel. The target tissue is illuminated by two discrete optical wavelengths. An average light intensity distribution is detected over the length of a pulse. The distribution is Fournier transformed, and the largest Fournier components and spectral position are determined in relation to the frequency of the ultrasonic radiation. The component concentration in the blood vessel is calculated taking into account the volume of the ultrasonic focus contributing to the signal and blood flow rate.
    Type: Grant
    Filed: March 10, 2004
    Date of Patent: July 31, 2007
    Assignee: Nirlus Engineering AG
    Inventor: Vera Herrmann