Abstract: Methods and Compositions involving the administration of guanosine, identified as Toll like receptor (TLR) 2 and 4 agonists, that will be useful for enhancing the potency of vaccine and cancer immunotherapies are disclosed. Method of preventing and treating cancer and infection by administration of guanosine or pro-drugs of guanosine, or a precursor of guanosine are also disclosed. Compositions of guanosine or a pro-drug of guanosine or precursor of guanosine may be formulated as pharmaceutical dosage forms and components can be assembled as kits. Methods for activating TLRs with guanosine to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of other antiviral, anti-bacterial and anticancer therapeutic agents are also disclosed.

Abstract: Methods and Compositions involving the administration of guanosine, identified as Toll like receptor (TLR) 2 and 4 agonists, that will be useful for enhancing the potency of vaccine and cancer immunotherapies are disclosed. Method of preventing and treating cancer and infection by administration of guanosine or pro-drugs of guanosine, or a precursor of guanosine are also disclosed. Compositions of guanosine or a pro-drug of guanosine or precursor of guanosine may be formulated as pharmaceutical dosage forms and components can be assembled as kits. Methods for activating TLRs with guanosine to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of other antiviral, anti-bacterial and anticancer therapeutic agents are also disclosed.

Abstract: Compositions including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful for enhancing the potency of vaccine and cancer immunotherapies being administered for the prevention or treatment of infectious diseases or cancer. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing the levels of endogenous adjuvants to enhance the immunogenicity of an antigen as well as to augment the potency of vaccine and cancer immunotherapies are also disclosed.

Abstract: Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful in the treatment of pathogen infection and cancer are disclosed. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing levels of endogenous adjuvants to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of therapeutic agents are also disclosed.

Abstract: Compositions and methods including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful in the treatment of pathogen infection and cancer are disclosed. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing levels of endogenous adjuvants to enhance an immune response and to potentiate/augment antiviral, antibacterial or anticancer effects of therapeutic agents are also disclosed.

Abstract: Compositions including at least one PNP inhibitor or at least one PNP inhibitor in combination with one or more agents identified as endogenous adjuvants useful for enhancing the potency of vaccine and cancer immunotherapies being administered for the prevention or treatment of infectious diseases or cancer. The compositions may be formulated as pharmaceutical dosage forms and components may be assembled as kits. Methods for increasing the levels of endogenous adjuvants to enhance the immunogenicity of an antigen as well as to augment the potency of vaccine and cancer immunotherapies are also disclosed.

Abstract: Method and apparatus for a multi-application, laser-array-based image system utilizes three linear laser arrays. Each linear array generates multiple (N>1) parallel output beamlets at one of the three primary colors (red, green, blue). The corresponding 1 to N output beamlets of the three linear arrays, each individually modulated in luminance according to a specific encoding scheme representing the video image to be produced on the viewing screen, are combined spatially to form a single white light linear array source. Through a projection/scanner optical system, the N output beamlets of the white light source are simultaneously directed to, and swept horizontally across a distant viewing screen, resulting in a swath of N lines of a graphic video image. By producing M contiguous swaths vertically down the viewing screen, a full image of M.times.N lines is produced.

Abstract: Method and apparatus for a multi-application, laser-array-based image system utilizes three linear laser arrays. Each linear array generates multiple (N>1) parallel output beamlets at one of the three primary colors (red, green, blue). The corresponding 1 to N output beamlets of the three linear arrays, each individually modulated in luminance according to a specific encoding scheme representing the video image to be produced on the viewing screen, are combined spatially to form a single white light linear array source. Through a projection/scanner optical system, the N output beamlets of the white light source are simultaneously directed to, and swept horizontally across a distant viewing screen, resulting in a swath of N lines of a graphic video image. By producing M contiguous swaths vertically down the viewing screen, a full image of M.times.N lines is produced.

Abstract: Method and apparatus for a multi-application, laser-array-based image system utilizes three linear laser arrays. Each linear array generates multiple (N>1) parallel output beamlets at one of the three primary colors (red, green, blue). The corresponding 1 to N output beamlets of the three linear arrays, each individually modulated in luminance according to a specific encoding scheme representing the video image to be produced on the viewing screen, are combined spatially to form a single white light linear array source. Through a projection/scanner optical system, the N output beamlets of the white light source are simultaneously directed to, and swept horizontally across a distant viewing screen, resulting in a swath of N lines of a graphic video image. By producing M contiguous swaths vertically down the viewing screen, a full image of M.times.N lines is produced.