Patents Assigned to Nordic Biociences A/S
  • Biochemical markers for CVD risk assessment
    Patent number: 9891234
    Abstract: A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of mimecan, a protein of an atherosclerotic plaque, by a proteinase is provided. In the method a sample, such as urine or serum, is contacted with an antibody reactive with the neo-epitope and the level of binding of the antibody to peptide fragments in the sample is determined. The assay is predictive of risk of cardiovascular disease events.
    Type: Grant
    Filed: May 4, 2012
    Date of Patent: February 13, 2018
    Assignee: Nordic Biociences A/S
    Inventors: Natasha Barascuk Michaelsen, Federica Genovese, Morten Karsdal, Diana Julie Leeming
  • Biochemical Markers for CVD Risk Assessment
    Publication number: 20150118698
    Abstract: A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage ofmimecan, a protein of an atherosclerotic plaque, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.
    Type: Application
    Filed: May 4, 2012
    Publication date: April 30, 2015
    Applicant: Nordic Biociences A/S
    Inventors: Natas[c]ha Barascuk Michaelsen, Federica Genovese, Morten Karsdal, Diana Julie Leeming