Abstract: In a method for capturing carbon, sulfur, and/or nitrogen from a target source, a matrix including activated metal dispersed in a metal activating agent is provided. The target source may be or include a carbon, sulfur, and/or nitrogen target compound. The target source is contacted with the matrix, wherein the activated metal reacts with the target source to produce elemental carbon, elemental sulfur, elemental nitrogen, and/or one or more compounds transformed from the target compound(s). The matrix may be produced by contacting a metal with the metal activating agent, and maintaining contact between the metal and the metal activating agent for a period of time sufficient for metal atoms from the solid metal to disperse in the metal activating agent. The reaction may also produce a metal compound. The activated metal may also be utilized in alkylation and other synthesis processes.
Abstract: Disclosed are methods and systems for determining concentrations of a target molecule and a variant thereof in a sample. The sample can comprise or be suspected to comprise a target molecule and at least one variant thereof and is exposed to one or more recognition elements that bind to the target molecule and/or the at least one variant. A signal is detected that is associated with the binding of the target molecule and/or a signal is detected that is associated with the binding of the at least one variant to the one or more recognition elements. The concentration of the target molecule and/or the at least one variant thereof is determined based on the signals. The system can comprise a receiver adapted to receive a sample comprising or suspected to comprise a target molecule and the at least one variant thereof, the receiver comprising one or more recognition elements that bind to one or more epitopes in the target molecule and/or the at least one variant thereof.
Type:
Grant
Filed:
December 20, 2019
Date of Patent:
April 5, 2022
Assignee:
North Carolina State University
Inventors:
Brian Michael Cummins, Frances Smith Ligler, Glenn Walker
Abstract: Compositions and methods for reducing the level of nornicotine and N?-nitrosonornicotine (NNN) in Nicotiana plants and plant parts thereof are provided. The compositions comprise isolated polynucleotides and polypeptides for cytochrome P450s that are involved in the metabolic conversion of nicotine to nornicotine in these plants. Expression cassettes, vectors, plants, and plant parts thereof comprising inhibitory sequences that target expression or function of the disclosed cytochrome P450 polypeptides are also provided. Methods for the use of these novel sequences to inhibit expression or function of cytochrome P450 polypeptides involved in this metabolic conversion are also provided. The methods find use in the production of tobacco products that have reduced levels of nornicotine and its carcinogenic metabolite, NNN, and thus reduced carcinogenic potential for individuals consuming these tobacco products or exposed to secondary smoke derived from these products.
Type:
Grant
Filed:
April 28, 2020
Date of Patent:
April 5, 2022
Assignees:
North Carolina State University, University of Kentucky Research Foundation
Inventors:
Ralph E. Dewey, Balazs Siminszky, Steven W. Bowen, Lily Gavilano
Abstract: The present disclosure provides compositions and methods related to the generation and use of transgenic animal models having stem cell reporter systems. In particular, the present disclosure provides a novel transgenic animal model that expresses a nuclear-localized fluorescent reporter in cells endogenously expressing a leucine-rich repeat-containing G-protein coupled receptor (LGR) gene (e.g., LGR5gene). Given the role of LGR genes in stem cell and cancer biology, the transgenic animal models provided herein are useful for a wide range of therapeutic and diagnostic purposes.
Abstract: A vertical insulated-gate field effect transistor includes a semiconductor substrate and a gate electrode on a first surface thereof. This gate electrode has a plurality of eight (or more) sided openings extending therethrough. Each of these openings has eight (or more) sidewalls, including a first plurality of sidewalls that are flat relative to a center of the opening and second plurality of sidewalls that are either flat or concave relative to the center of the opening. A source electrode is also provided, which extends into the openings. This source electrode may ohmically contact a source region within the semiconductor substrate. If the field effect transistor is a JBSFET, the source electrode may also form a Schottky rectifying junction with a drift region within the semiconductor substrate.
Abstract: Methods for treating diseases and conditions mediated by the high affinity IgE receptor (Fc?RI). Antisense oligomers for modulating splicing of mRNA encoding the Fc?RI? protein, thereby down-regulating cell-surface expression of Fc?RI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.
Type:
Grant
Filed:
August 1, 2018
Date of Patent:
March 8, 2022
Assignees:
North Carolina State University, The United States of America, as represented by the Secretary, Department of Health and Human Services
Abstract: Selective recovery of C2 to C4 hydrocarbons is achieved through the use of a converging-diverging nozzle, or de Laval nozzle. The vapor stream comprising C2 to C4 hydrocarbons is fed into an inlet of a de Laval nozzle having a throat. The vapor stream may have an initial temperature of between 0° C. and 100° C., and an initial pressure of between 200 psig and 500 psig. In the de Laval nozzle, the vapor stream expands after passing through the throat of the de Laval nozzle, producing a vapor stream having re-duced temperature and pressure. Then, C2 to C4 hydrocarbons condense from the reduced-temperature vapor stream as liquid droplets, which may be recovered. Fractionation of C2 to C4 hydrocarbons by means of a de Laval nozzle is possible; the technique allows select-ive recovery of propane from a mixture of propane and ethane.
Type:
Grant
Filed:
May 12, 2020
Date of Patent:
March 8, 2022
Assignees:
Eastman Chemical Company, North Carolina State University
Inventors:
Ashfaq Shahanawaz Shaikh, Thomas Allen Puckette, Scott Owens, Syed Maaz, Jack R. Edwards
Abstract: This invention relates to the use of CRISPR nucleic acids to screen for essential and non-essential genes and expendable genomic islands in bacteria, archaea, algae and/or yeast, to kill bacteria, archaea, algae and/or yeast, to identify the phenotype of a gene or genes, and/or to screen for reduced genome size and/or a gene deletion in bacteria, archaea, algae and/or yeast.
Abstract: The present invention relates to methods and compositions for maggot debridement therapy. More specifically, the invention relates to recombinant nucleic acid constructs, transgenic maggots comprising the recombinant nucleic acids, methods for making the maggots, and methods for the use of the maggots, including debridement and promoting of wound healing.
Type:
Grant
Filed:
March 16, 2018
Date of Patent:
February 15, 2022
Assignee:
NORTH CAROLINA STATE UNIVERSITY
Inventors:
Maxwell J. Scott, Rebecca J. Davis, Esther J. Belikoff
Abstract: The invention relates to methods and compositions for modifying naturally non-mycorrhizal plants to produce modified plants that can be colonized by a mycorrhizal fungus having increased nitrogen and phosphorus uptake, increased drought tolerance/resistance, increased resistance to fungal and/or bacterial pathogens, and/or increased growth rate, yield and/or biomass production of a naturally non-mycorrhizal plant. The invention further relates to plants, plant parts, and/or plant cells produced by the methods of the invention as well as harvested and processed products from the plants, plant parts, and/or plant cells.
Abstract: Various examples related to shifted fractional pitch wye-delta multilayer windings and their use in AC machines. In one example, a winding includes a first wye-delta winding with first wye and delta windings for each phase and a second wye-delta winding with second wye and delta windings for each phase. The first and second wye windings for each phase are connected in series and the first and second delta windings are connected in series, and formed wye and delta windings are connected in a wye-delta configuration thereby providing an electrical phase shift between the two windings. The windings are interdigitated to provide a physical shift between the first and second wye windings and the first and second delta windings. Such windings can be used in, e.g., permanent magnet synchronous machines, synchronous machines, reluctance machines, and induction machines.
Abstract: Processes and systems for non-destructively storing, accessing, and editing information using nucleic acids are disclosed. Representative processes include a process for extracting a data file from a database, wherein the data file comprises information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for expanding a number of unique data files in a database that can be addressed with a predetermined number of oligonucleotide primers, wherein the unique data files each comprise information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for differentially reading information encoded into one or more polynucleotide strands; a process for manipulating files while in storage; and a process for extracting a data file from a database, wherein the data file comprises information encoded into a polynucleotide strand.
Type:
Application
Filed:
August 30, 2019
Publication date:
January 27, 2022
Applicant:
North Carolina State University
Inventors:
Albert Jun Qi Keung, James M. Tuck, III, Kevin Volkel, Kyle Tomek, Kevin Lin
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX5’ having a profusion of large, double white flowers with a yellow-green blotch, cold-hardiness in USDA Zone 6b, consistent reblooming in Fall, dense habit, and a tetraploid cytotype. The new cultivar is a Rhododendron, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
January 25, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX8’ having prolific, bright cherry-red single flowers, cold hardy to USDA Zone 6b, consistent Fall reblooming, and a dense, compact habit. The new cultivar is a Rhododendron, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
February 1, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX7’ having prolific, large, semi-double, deep pink flowers, a compact (mid-sized) habit, cold hardiness to USDA Zone 6b, and consistent Fall reblooming.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
February 1, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: A new and distinct cultivar of Rhododendron plant named ‘NCRX6’ having a profusion of bright red/orange single flowers, cold-hardiness to USDA 6b, consistent Fall reblooming, a dense habit, and tetraploid cytotype. Plants exhibit mid-sized habit and propagate readily from stem cuttings. The new cultivar is a Rhododendron, suitable for ornamental garden purposes.
Type:
Grant
Filed:
June 9, 2021
Date of Patent:
February 8, 2022
Assignee:
North Carolina State University
Inventors:
Thomas Green Ranney, Darren Touchell, Irene Palmer, Andra Nus, Nathan P. Lynch
Abstract: Ipomoea batatas ‘NCPUR13-0315’ is a purple fleshed, smooth skinned, dark purple-colored, table stock sweetpotato. ‘NCPUR13-0315’ has good yields of well-shaped and uniformly sized No.1 sized roots. It is a mid-season cultivar for optimal production of No.1 sized roots.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
April 5, 2022
Assignee:
NORTH CAROLINA STATE UNIVERSITY
Inventors:
George Craig Yencho, Kenneth Vincent Pecota
Abstract: Ipomoea batatas ‘NC04-0531’ is an orange fleshed, smooth skinned, dark rose-colored, table stock sweetpotato. ‘NC04-0531’ has good insect resistance. It has an upright, compact canopy that helps to suppress weeds within a row and is slower to trail across rows allowing for a longer period of cultivation with weed control. It is a long season variety to size for optimal production of No. 1 sized roots. Size and shape uniformity of ‘NC04-0531’ are very good. The flavor of the baked storage roots of ‘NC04-0531’ has been judged to be very good by standardized and informal taste panels. Because of its insect resistance and plant canopy characteristics, ‘NC04-0531’ is seen as a good option for organic production.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
April 12, 2022
Assignee:
NORTH CAROLINA STATE UNIVERSITY
Inventors:
George Craig Yencho, Kenneth Vincent Pecota
Abstract: Ipomoea batatas ‘NCPUR13-0030’ is a purple fleshed, smooth skinned, dark purple-colored, table stock sweetpotato. ‘NCPUR13-0030’ produces high yields of well-shaped and uniformly sized No. 1 sized roots. It is a mid-season variety. The flavor of the baked storage roots of ‘NCPUR13-0030’ have been judged to be good by standardized and informal taste panels.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
April 12, 2022
Assignee:
NORTH CAROLINA STATE UNIVERSITY
Inventors:
George Craig Yencho, Kenneth Vincent Pecota