Patents Assigned to North Shore University Hospital Research Corp.
  • Method and kits for detection of fragile X specific, GC-rich DNA sequences
    Patent number: 6200747
    Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.
    Type: Grant
    Filed: January 28, 1992
    Date of Patent: March 13, 2001
    Assignee: North Shore University Hospital Research Corp.
    Inventors: Robert G. Pergolizzi, Susan H. Erster, W. Ted Brown
  • Identification of differentially methylated and mutated nucleic acids
    Patent number: 5871917
    Abstract: The present invention provides Methyl- (or Mutant-) Differential Display (MDD) methods and nucleic acid probes for detecting mutations and the methylation patterns of nucleic acids. The methods of the present invention are particularly useful for detecting and isolating genomic DNA fragments which are near coding and regulatory regions of genes and which are differentially mutated or methylated relative to the corresponding DNA from normal cells. Genes are frequently not methylated in the cells where they are expressed but are methylated in cell types where they are not expressed. Moreover, tumor cell DNA is frequently methylated to a different extent and in different regions than is the DNA of normal cells. The present invention is used for identifying which regions of the genome are methylated or mutated in different cell types, including cancerous cell types.
    Type: Grant
    Filed: May 31, 1996
    Date of Patent: February 16, 1999
    Assignee: North Shore University Hospital Research Corp.
    Inventor: Hao-peng Xu Duffy
  • Method of reducing medical device related infections
    Patent number: 5716406
    Abstract: The growth of microorganisms on catheters and other medical devices is inhibited by slime-inhibiting compounds. Slime-inhibiting compounds include salicylic acid and other NSAID.
    Type: Grant
    Filed: July 25, 1994
    Date of Patent: February 10, 1998
    Assignee: North Shore University Hospital Research Corp.
    Inventor: Bruce Farber
  • Method and kits for detection of fragile X specific, GC-rich DNA sequences
    Patent number: 5658764
    Abstract: A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the presence of dATP, dCTP, TTP, and an analogue of dGTP. In one application of the present invention, individuals who are carriers for, or afflicted by, the fragile X syndrome are detected.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: August 19, 1997
    Assignee: North Shore University Hospital Research Corp.
    Inventors: Robert G. Pergolizzi, Susan H. Erster, W. Ted Brown