Abstract: Storage media are provided. A substrate has an array of addressable locations thereon, each addressable location adapted to be physically associated with a collection of molecules, each collection comprising at least a first subcollection of molecules and a second subcollection of molecules. The molecules in the collection are selected from a set of unambiguously identifiable molecules, the set comprising at least a first subset of molecules and a second subset of molecules. Each molecule in the first subset is identifiable by a first physical property, and each molecule in the second subset is identifiable by a second physical property, different from the first physical property. Each molecule in the set is uniquely associated with a predetermined position in a numerical value, wherein the presence of the molecule in the collection indicates a predetermined digit at the associated position and the absence of said molecule in the collection indicates a zero at said associated position.

Abstract: Disclosed are new polycyclic carbogenic molecules and their methods of synthesis. The new polycyclic carbogenic molecules may be utilized in anti-cancer therapies. In particular, the polycyclic carbogenic molecules may be formulated as pharmaceutical compositions that comprise the small molecules, which compositions may be administered in methods of treating and/or preventing cell proliferative diseases and disorders such as cancer. The new polycyclic carbogenic molecules may be prepared from vinyl- or allyl-substituted cyclohexenone precursors via preparation of a silyl bis-enol ether intermediate.

Abstract: Disclosed are compounds that bind to embryonic ectoderm development (EED) protein and proteolysis-targeting chimeric (PROTAC) derivatives thereof that induce degradation of EED. The disclosed compounds may be characterized as substituted [1,2,4]triazolo[4,3-c]pyrimidin-5-amine compounds. The disclosed PROTAC derivatives thereof typically include a first targeting moiety that binds to EED (MEED) which may be derived from the disclosed [1,2,4]triazolo[4,3-c]pyrimidin-5-amine compounds that bind to EED. The first targeting moiety typically is linked via a bond or a linker (L) to a second targeting moiety that binds to an E3 ubiquitin ligase (ME3). As such, the disclosed PROTACS may be described as having a formula MEED-L-ME3 or ME3-L-MEED, wherein MEED has a formula of where R2, n, and x are as described herein.

Abstract: Electrocatalytic materials and methods of making the electrocatalytic materials are provided. Such a method may comprise forming precursor nanosheets comprising a precursor metal on a surface of a substrate; exposing the precursor nanosheets to a modifier solution comprising a polar, aprotic solvent and a metal salt at a temperature and for a period of time, the metal salt comprising a metal cation and an anion, thereby forming modified precursor nanosheets; and calcining the modified precursor nanosheets for a period of time to form an electrocatalytic material comprising structurally modified nanosheets and the substrate, each nanosheet extending from the surface of the substrate and having a solid matrix.

Abstract: In various embodiments functionalized graphene oxide(s) are provided that demonstrate improved antimicrobial activity, where the graphene oxide(s) are functionalized to increase carbon radical (·C) density.

Abstract: Disclosed herein are methods for live-cell imaging, compositions for performing the live cell imaging, and methods for making the composition. The method may comprise contacting a cell with an effective amount of a catenane, irradiating the cell, and detecting exciplex emission from the catenane within the cell. The catenane may comprise two mechanically interlocked macrocycles, each of the two macrocycles comprise an aromatic fluorophore subunit, and the aromatic fluorophores are arranged in a face-to-face [? . . . ?] stack allowing for the exciplex emission.

Abstract: Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.

Abstract: Medical devices and systems for treating a stricture, for example along the biliary and/or pancreatic tract, are disclosed. An example system may include a guidewire having a distal end and defining a lumen. A stiffening rod may be slidably disposed within the lumen. The stiffening rod may have a distal end and a distal end region disposed adjacent to the distal end. The stiffening rod may be configured to shift between a first position where the distal end of the stiffening rod is disposed proximally of the distal end of the guidewire and a second position where the distal end of the stiffening rod is disposed distally of the distal end of the guidewire.

Abstract: The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more components of frequency-following response (FFR) following administration of an acoustic stimulus to the subject. In addition, the present disclosure provides methods for assessing a subject's recovery from a non-penetrating brain injury. Also disclosed herein are processes and systems for automatically generating acoustic stimuli and processing brain response data to identify non-penetrating brain injuries in subjects.

Abstract: Provided herein are compositions comprising peptide amphiphiles, glycosylated peptide amphiphiles (GPAs), supramolecular nanostructures assembled therefrom, and methods of use thereof. The peptide amphiphiles described herein may extend the half-life of bone morphogenic proteins, promote cell differentiation, suppress proliferation, and increase chemosensitivity of cells. Accordingly, the compositions described herein may be used for cancer treatment methods. In particular, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same for the treatment of cancer. Also, provided herein are bone morphogenic proteins bound to peptide amphiphiles and glycosylated peptide amphiphiles or composites thereof, and methods of use of the same in a combinatorial approach together with chemotherapeutic medications for the treatment of cancer.

Abstract: Described herein are isolated peptides, compositions comprising the same, and methods of using such peptides or compositions in the treatment of depression, central nervous system disorders, and neurodevelopmental disorders.

Abstract: Disclosed are polynucleotides, compositions, and methods related to RNA interference (RNAi). Particular disclosed are toxic RNAi active seed sequences and methods of using toxic RNAi active sequences for killing cancer cells. The disclosed toxic RNAi active seed sequences preferentially target and inhibit the expression of multiple essential genes for cell survival and/or growth through a process called “death-induced by survival gene elimination” or “DISE.” The disclosed toxic RNAi active seed sequences may be referred to as “dual activity super toxic RNAi active dsRNAs” that include a toxic first strand and a toxic second strand that is complementary to the toxic first strand. As such, the disclosed dsRNAs may be expressed as shRNAs which are processed for RNA interference (RNAi) and either of the toxic first strand and the toxic second strand can function as a guide strand to initiate RNAi.

Abstract: The invention relates generally to compositions and methods for the detection of zinc. Provided herein is a class of zinc-responsive probes with tunable photophysical properties that can be modified for coupling to a solid support or other chemical moieties. In particular, modifications to the 5-position of the BODIPY core allows for alteration of probe properties and functionalities.

Abstract: Systems formed by a multi-bit three-transistor (3T) memory cell (i.e., dynamic-analog RAM) are provided. The 3T memory cell includes: a read-access transistor M1 in electrical communication with a read bitline; a switch transistor M2 in electrical communication with the read-access transistor M1; a write-access transistor M3 in electrical communication with the read-access transistor M1 and a write bitline; and a memory node MEM in electrical communication between the read-access transistor M1 and the write-access transistor M3, wherein the memory node MEM is configured to store a 4-bit weight WE. An array of the 3T memory cells (i.e., dynamic-analog RAMs) may form a computing-in-memory (CIM) macro, and further form a convolutional neural network (CNN) accelerator by communicating with an application-specific integrated circuit (ASIC) which communicates with a global weight static random access memory and an activation static random access memory.

Abstract: Methods of reducing microbial attachment to a surface are provided, including methods comprising illuminating a surface comprising a substrate and a coating on the substrate with ultraviolet light, wherein the coating comprises anatase titanium dioxide nanoparticles functionalized with silver nanoparticles and is optically transparent to visible light; and exposing the illuminated surface to microbes. The coating exhibits a reduction in microbial attachment as compared to the coating absent the illumination.

Abstract: In one aspect of the invention, a dye sensitized solar cell has a counter-electrode including carbon-titania nanocomposite thin films made by forming a carbon-based ink; forming a titania (TiO2) solution; blade-coating a mechanical mixture of the carbon-based ink and the titania solution onto a substrate; and annealing the blade-coated substrate at a first temperature for a first period of time to obtain the carbon-based titania nanocomposite thin films. In certain embodiments, the carbon-based titania nanocomposite thin films may include solvent-exfoliated graphene titania (SEG-TiO2) nanocomposite thin films, or single walled carbon nanotube titania (SWCNT-TiO2) nanocomposite thin films.

Abstract: A method for creating metadevices includes receiving, at a computing device, one or more boundary conditions for a metadevice. The method also includes processing, with an inverse-design algorithm stored in a memory of the computing device, the one or more boundary conditions to generate a metadevice structure design that satisfies the one or more boundary conditions. The method also includes converting, by a processor of the computing device, the metadevice structure design into a file that is compatible with an additive manufacturing device. The method further includes providing the file of the metadevice structure design to the additive manufacturing device.

Abstract: Composite electrocatalytic materials for catalyzing water splitting are provided. Such materials may comprise a porous, conductive support composed of a transition metal foam, the support having a surface, and a coating on the surface of the support. The coating may comprise nanorods of a first transition metal chalcogenide, each nanorod anchored on one end to the surface of the support and extending perpendicularly away from the surface of the support to a free opposing end, nanosheets of a second transition metal chalcogenide, the nanosheets coating a surface of the nanorods of the first transition metal chalcogenide, and nanosheets of a third transition metal chalcogenide, the nanosheets also coating the surface of the nanorods of the first transition metal chalcogenide.

Abstract: A composite film usable as a separator of an electrochemical device includes hBN nanosheets and at least one polymer. The hBN nanosheets are uniformly dispersed within a matrix of said least one polymer to achieve a highly porous microstructure. Said at least one polymer comprises one or more electrically insulating and electrochemically inert polymers.

Abstract: A method for characterizing atrial fibrillation includes determining, by a processor of a computing device and based on heart data, an earliest activation time of a heart being monitored. The method also includes determining, by the processor and based on the heart data, a latest activation time of the heart. The method also includes modeling, by the processor, the earliest activation time and the latest activation time within one or more activation time maps. The method further includes identifying, by the processor, an atrial fibrillation driver based at least in part on the one or more activation time maps.