Patents Assigned to Northfield Laboratories
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Patent number: 7521417Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: GrantFiled: January 10, 2008Date of Patent: April 21, 2009Assignee: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Patent number: 7435795Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: GrantFiled: February 23, 2007Date of Patent: October 14, 2008Assignee: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Patent number: 7411044Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: GrantFiled: August 24, 2006Date of Patent: August 12, 2008Assignee: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Patent number: 7291592Abstract: Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.Type: GrantFiled: October 3, 2003Date of Patent: November 6, 2007Assignee: Northfield Laboratories, Inc.Inventors: Steven Gould, Richard DeWoskin, Marc Doubleday, George Hides
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Publication number: 20070173435Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: ApplicationFiled: February 23, 2007Publication date: July 26, 2007Applicant: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Patent number: 7202341Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: GrantFiled: September 21, 2005Date of Patent: April 10, 2007Assignee: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Publication number: 20060287222Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: ApplicationFiled: August 24, 2006Publication date: December 21, 2006Applicant: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Patent number: 7135553Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: GrantFiled: January 29, 2004Date of Patent: November 14, 2006Assignee: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Publication number: 20060014671Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: ApplicationFiled: September 21, 2005Publication date: January 19, 2006Applicant: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Publication number: 20040186047Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: ApplicationFiled: January 29, 2004Publication date: September 23, 2004Applicant: Northfield LaboratoriesInventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Publication number: 20040067876Abstract: Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.Type: ApplicationFiled: October 3, 2003Publication date: April 8, 2004Applicant: Northfield Laboratories, Inc.Inventors: Steven A. Gould, Richard E. DeWoskin, Marc D. Doubleday, George A. Hides
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Publication number: 20030191050Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: ApplicationFiled: October 17, 2002Publication date: October 9, 2003Applicant: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Publication number: 20030130487Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: ApplicationFiled: January 21, 2003Publication date: July 10, 2003Applicant: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6552173Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: GrantFiled: November 27, 2001Date of Patent: April 22, 2003Assignee: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Publication number: 20030065149Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: ApplicationFiled: April 18, 2002Publication date: April 3, 2003Applicant: Northfield LaboratoriesInventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Patent number: 6498141Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: GrantFiled: May 10, 1999Date of Patent: December 24, 2002Assignee: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Publication number: 20020062007Abstract: An a cellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said a cellular red blood cell substitute.Type: ApplicationFiled: November 27, 2001Publication date: May 23, 2002Applicant: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6323320Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: GrantFiled: August 14, 2000Date of Patent: November 27, 2001Assignee: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6248366Abstract: The present invention relates to dairy compositions and, more particularly, to dairy compositions containing colostrum. The applicant has discovered that colostrum can be processed so as to reduce the bioburden of liquid colostrum while retaining the biological activity of certain proteins including the immunoglobulin fraction. By this process it is possible to introduce liquid colostrum into pasteurized and unpasteurized dairy products. In one aspect of the invention there is provided a process for the preparation of a liquid colostrum product, suitable for inclusion in dairy products, which process includes subjecting colostrum to centrifugation to substantially reduce the microbial content thereof.Type: GrantFiled: May 9, 2000Date of Patent: June 19, 2001Assignee: Northfield Laboratories Pty Ltd.Inventor: Antony William Scammell
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Patent number: 6202546Abstract: The present invention relates to dairy compositions and, more particularly, to dairy compositions containing colostrum. The applicant has discovered that colostrum can be processed so as to reduce the bioburden of liquid colostrum while retaining the biological activity of certain proteins including the immunoglobulin fraction. By this process it is possible to introduce liquid colostrum into pasteurized and unpasteurized dairy products. In one aspect of the invention there is provided a process for the preparation of a liquid colostrum product, suitable for inclusion in dairy products, which process includes subjecting colostrum to centrifugation to substantially reduce the microbial content thereof.Type: GrantFiled: May 7, 1998Date of Patent: March 20, 2001Assignee: Northfield Laboratories Pty. LTDInventor: Antony William Scammell