Patents Assigned to Northfield Laboratories, Inc.
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Patent number: 7521417Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: GrantFiled: January 10, 2008Date of Patent: April 21, 2009Assignee: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Patent number: 7435795Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: GrantFiled: February 23, 2007Date of Patent: October 14, 2008Assignee: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Patent number: 7411044Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: GrantFiled: August 24, 2006Date of Patent: August 12, 2008Assignee: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Patent number: 7291592Abstract: Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.Type: GrantFiled: October 3, 2003Date of Patent: November 6, 2007Assignee: Northfield Laboratories, Inc.Inventors: Steven Gould, Richard DeWoskin, Marc Doubleday, George Hides
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Publication number: 20070173435Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: ApplicationFiled: February 23, 2007Publication date: July 26, 2007Applicant: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Patent number: 7202341Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: GrantFiled: September 21, 2005Date of Patent: April 10, 2007Assignee: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Publication number: 20060287222Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: ApplicationFiled: August 24, 2006Publication date: December 21, 2006Applicant: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Patent number: 7135553Abstract: A substantially tetramer free hemoglobin solution and a method for producing a substantially tetramer free hemoglobin solution. The method includes polymerizing a solution of hemoglobin, treating the polymerized hemoglobin solution to partially degrade the polymer to tetramer and removing tetramer from the hemoglobin solution.Type: GrantFiled: January 29, 2004Date of Patent: November 14, 2006Assignee: Northfield Laboratories, Inc.Inventors: Anthony Avella, Richard DeWoskin, Marc Doubleday
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Publication number: 20060014671Abstract: A hemoglobin solution packaged in a flexible oxygen-impermeable container system. The container system includes a multi-layer film having at least a product contact layer, an oxygen and moisture barrier layer and an exterior layer. The flexible container system further includes an interface port for filling the flexible container with the hemoglobin solution and delivering the hemoglobin solution. The hemoglobin solution comprises a substantially stroma and tetramer free, cross linked, pyridoxylated hemoglobin solution including preservatives such as ascorbic acid, glycine and dextrose.Type: ApplicationFiled: September 21, 2005Publication date: January 19, 2006Applicant: Northfield Laboratories, Inc.Inventors: Robert McGinnis, Gabriel Chavez, Marc Doubleday, Richard DeWoskin, Anthony Avella
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Publication number: 20040067876Abstract: Methods for treating a mammal suffering from massive blood loss comprising administering to the mammal a polymerized hemoglobin solution.Type: ApplicationFiled: October 3, 2003Publication date: April 8, 2004Applicant: Northfield Laboratories, Inc.Inventors: Steven A. Gould, Richard E. DeWoskin, Marc D. Doubleday, George A. Hides
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Publication number: 20030191050Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: ApplicationFiled: October 17, 2002Publication date: October 9, 2003Applicant: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Publication number: 20030130487Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: ApplicationFiled: January 21, 2003Publication date: July 10, 2003Applicant: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6552173Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: GrantFiled: November 27, 2001Date of Patent: April 22, 2003Assignee: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6498141Abstract: A process is disclosed for the preparation of an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin. Also disclosed is an essentially tetramer-free, substantially stroma-free, polymerized, pyridoxylated hemoglobin product capable of being infused into human patients in an amount of up to about 5 liters.Type: GrantFiled: May 10, 1999Date of Patent: December 24, 2002Assignee: Northfield Laboratories, Inc.Inventors: Richard E. DeWoskin, Marc D. Doubleday
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Publication number: 20020062007Abstract: An a cellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said a cellular red blood cell substitute.Type: ApplicationFiled: November 27, 2001Publication date: May 23, 2002Applicant: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. DeWoskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6323320Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: GrantFiled: August 14, 2000Date of Patent: November 27, 2001Assignee: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 6133425Abstract: An acellular red blood cell substitute which comprises an essentially tetramer-free, substantially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin and a nontoxic, pharmaceutically acceptable carrier, its use and a process for preparing said acellular red blood cell substitute.Type: GrantFiled: March 15, 1993Date of Patent: October 17, 2000Assignee: Northfield Laboratories, IncInventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 5464814Abstract: A process is disclosed for the preparation of an essentially tetramer-free, essentially stroma-free, cross-linked, polymerized, pyridoxylated hemoglobin which comprises separating red blood cell stroma from blood by means of heat treating step to remove stromal contaminants and filtration or centrifugation or both, pyridoxylating, polymerizing, and removing essentially all of the remaining unmodified tetramer.Type: GrantFiled: February 28, 1994Date of Patent: November 7, 1995Assignee: Northfield Laboratories, Inc.Inventors: Lakshman R. Sehgal, Richard E. De Woskin, Gerald S. Moss, Steven A. Gould, Arthur L. Rosen, Hansa Sehgal
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Patent number: 5438041Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.Type: GrantFiled: March 3, 1993Date of Patent: August 1, 1995Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.Inventors: Shuming Zheng, Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
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Patent number: 5217648Abstract: A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.Type: GrantFiled: October 11, 1991Date of Patent: June 8, 1993Assignees: Illinois Institute of Technology, Northfield Laboratories, Inc.Inventors: Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen