Abstract: The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.
Type:
Application
Filed:
October 16, 2020
Publication date:
April 8, 2021
Applicant:
NOVALIQ GMBH
Inventors:
Bernhard GUNTHER, Bastian THEISINGER, Sonja THEISINGER, Dieter SCHERER
Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutyl-pentane. The compositions may be used for topical administration to the eye.
Type:
Application
Filed:
October 13, 2020
Publication date:
January 28, 2021
Applicant:
NOVALIQ GMBH
Inventors:
Frank LÖSCHER, Ralf GRILLENBERGER, Johan ENGBLOM
Abstract: The invention provides liquid compositions in the form of physically stable emulsions comprising a semifluorinated alkane. The semifluorinated alkane is comprised in the dispersed phase, which may also include an active pharmaceutical ingredient. One of the preferred active ingredients is propofol. The compositions are optionally heat sterilisable and can be used for pharmaceutical or cosmetic product applications, and administered topically, intravenously, or via other routes.
Type:
Application
Filed:
April 30, 2020
Publication date:
November 19, 2020
Applicant:
NOVALIQ GMBH
Inventors:
Bastian THEISINGER, Sonja THEISINGER, Bernhard GÜNTHER
Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.
Type:
Application
Filed:
May 14, 2020
Publication date:
October 29, 2020
Applicant:
NOVALIQ GMBH
Inventors:
Dieter SCHERER, Ralf GRILLENBERGER, Frank LÖSCHER, Hartmut VOSS
Abstract: The invention provides liquid or semi-solid pharmaceutical compositions for topical administration comprising a semifluorinated alkane. The compositions are useful for the delivery of active ingredients into the deep layers of the skin or skin appendages. Various active ingredients may be incorporated, such as immunosuppressants, antiinfectives, antifungal agents, antiinflammatory agents, and retinoids.
Type:
Grant
Filed:
September 29, 2017
Date of Patent:
October 27, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Gunther, Bastian Theisinger, Sonja Theisinger, Dieter Scherer
Abstract: The present invention relates to compositions in the form of a clear solution comprising ciclosporin with low residual water content and 1-perfluorobutylpentane. The compositions may be used for topical administration to the eye.
Type:
Grant
Filed:
September 22, 2017
Date of Patent:
October 27, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Frank Löscher, Ralf Grillenberger, Johan Engblom
Abstract: The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
Type:
Application
Filed:
February 6, 2020
Publication date:
August 6, 2020
Applicant:
Novaliq GmbH
Inventors:
Bernhard GÜNTHER, Dieter SCHERER, Anthony PETTIGREW, Bastian THEISINGER, Sonja THEISINGER
Abstract: The invention provides novel pharmaceutical compositions for the treatment of increased intraocular pressure based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble prostaglandin analogues. The compositions can be administered topically into the eye. The invention further provides kits comprising such compositions.
Type:
Application
Filed:
December 31, 2019
Publication date:
July 2, 2020
Applicant:
NOVALIQ GMBH
Inventors:
Bastian THEISINGER, Sonja THEISINGER, Bernhard GÜNTHER
Abstract: The present invention is directed to compositions comprising semifluorinated compounds and their use as medicaments for topical administration to the eye.
Type:
Grant
Filed:
November 5, 2018
Date of Patent:
June 16, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Dieter Scherer, Ralf Grillenberger, Frank Löscher, Hartmut Voss
Abstract: The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
July 20, 2018
Date of Patent:
March 3, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Dieter Scherer, Anthony Pettigrew, Bastian Theisinger, Sonja Theisinger
Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble prostaglandin analogues. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
April 17, 2019
Date of Patent:
February 11, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Bastian Theisinger, Sonja Theisinger, Bernhard Günther
Abstract: The invention provides novel pharmaceutical compositions for the treatment of increased intraocular pressure based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble prostaglandin analogues. The compositions can be administered topically into the eye. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
June 25, 2018
Date of Patent:
January 7, 2020
Assignee:
NOVALIQ GMBH
Inventors:
Bastian Theisinger, Sonja Theisinger, Bernhard Günther
Abstract: The present invention relates to a method for topical administration of ophthalmic compositions in a dropwise manner, preferably for topical administration of ophthalmic compositions comprising semifluorinated alkanes (SFAs). Further, the present invention relates to the use of said methods in the prevention or treatment of ocular diseases or disorders or any symptoms or conditions associated therewith. In a further aspect, the present invention relates to a kit comprising a drop dispenser at least partially filled with a liquid composition for the use in such a method and directions for use of said drop dispenser.
Type:
Grant
Filed:
June 21, 2017
Date of Patent:
December 17, 2019
Assignee:
NOVALIQ GMBH
Inventors:
Gesche Graf, Yasin Ahmed, Stephanie Legner, Philip Kemp
Abstract: The invention provides novel compositions comprising at least two or more semifluorinated alkanes. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue, such as for use in the treatment of keratoconjunctivitis sicca (dry eye) and/or meibomian gland dysfunction and symptoms associated therewith. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
September 12, 2013
Date of Patent:
October 22, 2019
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Bastian Theisinger, Sonja Theisinger, Dieter Scherer
Abstract: The invention provides novel compositions of antibodies based on liquid vehicles selected from semifluorinated alkanes. The use of these vehicles provides for improved stability and shelf-life of antibodies and their derivatives. The compositions are useful for topical administration or for parenteral injection.
Type:
Application
Filed:
March 6, 2019
Publication date:
August 22, 2019
Applicant:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Dieter Scherer, Anthony Pettigrew, Gesche Graf
Abstract: The invention provides novel pharmaceutical compositions based on semifluorinated alkanes which are useful as carriers for a broad range of active ingredients. Preferred active ingredients include poorly water-soluble prostaglandin analogues. The invention further provides kits comprising such compositions.
Type:
Application
Filed:
April 17, 2019
Publication date:
August 8, 2019
Applicant:
NOVALIQ GMBH
Inventors:
Bastian THEISINGER, Sonja THEISINGER, Bernhard GÜNTHER
Abstract: The invention provides novel compositions comprising at least two or more semifluorinated alkanes. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue, such as for use in the treatment of keratoconjunctivitis sicca (dry eye) and/or meibomian gland dysfunction and symptoms associated therewith. The invention further provides kits comprising such compositions.
Type:
Grant
Filed:
September 21, 2017
Date of Patent:
August 6, 2019
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Bastian Theisinger, Sonja Theisinger, Dieter Scherer
Abstract: The invention provides liquid compositions in the form of physically stable emulsions comprising a semifluorinated alkane. The semifluorinated alkane is comprised in the dispersed phase, which may also include an active pharmaceutical ingredient. One of the preferred active ingredients is propofol. The compositions are optionally heat sterilisable and can be used for pharmaceutical or cosmetic product applications, and administered topically, intravenously, or via other routes.
Type:
Application
Filed:
January 28, 2019
Publication date:
July 25, 2019
Applicant:
NOVALIQ GMBH
Inventors:
Bastian THEISINGER, Sonja THEISINGER, Bernhard GÜNTHER
Abstract: The invention provides novel compositions of antibodies based on liquid vehicles selected from semifluorinated alkanes. The use of these vehicles provides for improved stability and shelf-life of antibodies and their derivatives. The compositions are useful for topical administration or for parenteral injection.
Type:
Grant
Filed:
July 23, 2014
Date of Patent:
April 30, 2019
Assignee:
NOVALIQ GMBH
Inventors:
Bernhard Günther, Dieter Scherer, Anthony Pettigrew, Gesche Graf