Patents Assigned to Novartis Finance Corporation
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Patent number: 5847258Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: December 8, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Mary B. Moyer, George B. Payne, Eric R. Ward
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Patent number: 5843982Abstract: When used in admixture with fludioxonil, metalaxyl having a high R-enantiomer content of more than 70% by weight, or pure R-metalaxyl, exhibits a markedly enhanced fungicidal action against plant diseases. At the same time, the high R-enantiomer content accelerates the degradability of metalaxyl in the soil.Type: GrantFiled: February 14, 1997Date of Patent: December 1, 1998Assignee: Novartis Finance CorporationInventor: Neil Leadbitter
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Patent number: 5840868Abstract: The present invention is drawn to pesticidal strains and proteins. Bacillus strains which are capable of producing pesticidal proteins and auxiliary proteins during vegetative growth are provided. Also provided are the purified proteins, nucleotide sequences encoding the proteins and methods for using the strains, proteins and genes for controlling pests.Type: GrantFiled: June 6, 1995Date of Patent: November 24, 1998Assignee: Novartis Finance CorporationInventors: Gregory W. Warren, Michael G. Koziel, Martha A. Mullins, Brian Carr, Nalini M. Desai, Kristy Kostichka
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Patent number: 5837839Abstract: We have cloned and expressed the cDNA for human liver mevalonate pyrophosphate decarboxylase, an enzyme of the cholesterol synthesis pathway. This cDNA encodes a 400 amino acid protein (43 kDa) which resembles the coding sequence of an unidentified and incomplete open reading frame adjacent to the COQ2 gene of Saccharomyces cerevisiae. We also found an expression sequence tag clone made from human infant brain cDNA to be almost identical to our cDNA sequence.Type: GrantFiled: October 18, 1996Date of Patent: November 17, 1998Assignee: Novartis Finance CorporationInventors: Matthew John Toth, Leslie Robin Huwyler
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Patent number: 5831114Abstract: Substituted N-phenyl- and N-heteroarylalkylcarbamates of formula (I), in which Q is a group (1), (2) or (3); R is halogen, trifluoromethyl, cyano, nitro or C.sub.1 -C.sub.3 haloalkoxy; Z is hydrogen or halogen; or Z and R together in the 2- and 3-position of the phenyl ring form a group --OCF.sub.2 O--; R.sub.1 is C.sub.1 -C.sub.5 alkyl; R.sub.2, R.sub.3, R.sub.4 and R.sub.5, independently of one another, are hydrogen, methyl or ethyl; X is oxygen, sulfur, --SO-- or --SO.sub.2 --, Y is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy or cyano; n is 0, 1 or 2; n.sub.1 is 0 or 1; and m is 0 or 1, with the proviso that m is 1 if Q is group (1) or (2); and the diastereomers and enantiomers thereof, exhibit pre- and post-emergence herbicidal properties. The preparation of these compounds and their use as herbicidally active ingredients are described.Type: GrantFiled: May 28, 1997Date of Patent: November 3, 1998Assignee: Novartis Finance CorporationInventors: Hermann Rempfler, Fredrik Cederbaum, Felix Spindler, Willy Urs Lottenbach
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Patent number: 5827695Abstract: Internal Transcribed Spacer (ITS) DNA sequences from the ribosomal RNA gene region are described for different species and strains of wheat fungal pathogens, including Fusarium spp. and Microdochium nivale. Specific primers from within these sequences are identified as being useful for the identification of the fungal isolates using PCR-based techniques.Type: GrantFiled: August 1, 1997Date of Patent: October 27, 1998Assignee: Novartis Finance CorporationInventor: James Joseph Beck
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Patent number: 5824542Abstract: The present invention provides a dual method for producing male-sterile plants. Two genetically transformed plants, parents 1 and 2 are crossed to obtain male-sterile offspring. Parent 1 is transformed with an expression cassette comprising a nucleotide sequence encoding an anther-specific promoter which is operably linked to a nucleotide sequence encoding a transactivator. Parent 2 is transformed with an expression cassette comprising a target nucleotide sequence, which is capable of being activated by the transactivator, operably linked to a nucleotide sequence which encodes RNA or a polypeptide which will disrupt the formation of viable pollen. Therefore, crossing parent 1 with parent 2 results in male-sterile offspring. The male-sterile plants are useful for producing hybrid seed.The invention also provides compositions and methods for high level expression of a coding region of interest in a plant.Type: GrantFiled: May 23, 1995Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventors: Lyle D. Crossland, Annmarie Tuttle, Jeffrey I. Stein
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Patent number: 5824852Abstract: An inbred corn line, designated NP 2013, is disclosed. The invention relates to the seeds of inbred corn line NP 2013, to the plants of inbred corn line NP 2013 and to methods for producing a corn plant produced by crossing inbred line NP 2013 with itself or with another corn plant. The invention further relates to hybrid corn seeds and plants produced by crossing inbred line NP 2013 with another corn line.Type: GrantFiled: February 18, 1997Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventor: Thomas R. Francis
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Patent number: 5824302Abstract: According to the invention there is provided a method of controlling insect larvae comprising the steps of feeding said larvae an insecticidal amount of a transgenic Zea mays plant that expresses a polypeptide having the insect toxicity properties of Bacillus thuringiensis crystal protein.Type: GrantFiled: December 17, 1996Date of Patent: October 20, 1998Assignee: Novartis Finance CorporationInventors: Gleta Carswell, Christian Harms, Yin-Fu Chang, Mary-Dell Chilton
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Patent number: 5817502Abstract: The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.Type: GrantFiled: October 9, 1996Date of Patent: October 6, 1998Assignee: Novartis Finance CorporationInventors: James M. Ligon, Dwight Steven Hill, Stephen Ting Lam, Philip E. Hammer, Karl-Heinz van Pee, Sabine Kirner
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Patent number: 5817914Abstract: An inbred corn line, designated NP 993, is disclosed. The invention relates to the seeds of inbred corn line NP 993, to the plants of inbred corn line NP 993 and to methods for producing a corn plant produced by crossing inbred line NP 993 with itself or with another corn plant. The invention further relates to hybrid corn seeds and plants produced by crossing inbred line NP 993 with another corn line.Type: GrantFiled: October 16, 1996Date of Patent: October 6, 1998Assignee: Novartis Finance CorporationInventor: Monroe E. Howell
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Patent number: 5814453Abstract: Internal Transcribed Spacer (ITS) DNA sequences from the ribosomal RNA gene region are described for different species and strains of cereal fungal pathogens, including Septoria, Pseudocercosporella, Fusarium, Microdochium, and Mycosphaerella. Specific primers from within these sequences are identified as being useful for the identification of the fungal isolates using PCR-based techniques.Type: GrantFiled: July 2, 1997Date of Patent: September 29, 1998Assignee: Novartis Finance CorporationInventor: James Joseph Beck
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Patent number: 5814629Abstract: The invention relates to novel microbicidal and plant-immunising compounds of formula I ##STR1## wherein: X is hydrogen, halogen, C.sub.1 -C.sub.4 alkyl, SR.sub.8, N(R.sub.9)R.sub.10, CH.sub.2 OH, CHO or COOR.sub.8 ;R.sub.8 to R.sub.10 are hydrogen, C.sub.1 -C.sub.4 alkyl, benzyl, C.sub.1 -C.sub.4 acyl or benzoyl;Z is hydrogen, halogen, or a methyl group that is unsubstituted or to which from 1 to 3 unsubstituted or substituted hetero atoms O, S and/or N are bonded; in free form or in the form of salts. They can be used in crop protection for controlling and preventing disease infestation.Type: GrantFiled: December 19, 1996Date of Patent: September 29, 1998Assignee: Novartis Finance CorporationInventors: Peter Stanetty, Walter Kunz
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Patent number: 5811645Abstract: An inbred corn line, designated NP 2045, is disclosed. The invention relates to the seeds of inbred corn line NP 2045, to the plants of inbred corn line NP 2045 and to methods for producing a corn plant produced by crossing inbred line NP 2045 with itself or with another corn plant. The invention further relates to hybrid corn seeds and plants produced by crossing inbred line NP 2045 with another corn line.Type: GrantFiled: January 10, 1997Date of Patent: September 22, 1998Assignee: Novartis Finance CorporationInventor: Larry G. Balko
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Patent number: 5804693Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: September 8, 1998Assignee: Novartis Finance CorporationInventors: Thomas D. Gaffney, John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward, Helmut Kessmann, Bernardus T. Vernooij
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Patent number: 5800997Abstract: Internal Transcribed Spacer (ITS) DNA sequences from the ribosomal RNA gene region are described for different species and strains of Helminthosporium carbonum, Helminthosporium turcicum, Helminthosporium maydis, Cercospora zeae-maydis, Kabatiella zeae and Puccinia sorghi. Specific primers from within these sequences are identified as being useful for the identification of the fungal isolates using PCR-based techniques.Type: GrantFiled: November 1, 1996Date of Patent: September 1, 1998Assignee: Novartis Finance CorporationInventor: James Joseph Beck
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Patent number: 5792925Abstract: DNA sequences are able to function as promoters of tissue-preferential transcription of associated DNA sequences in plants, particularly in the roots. These DNA sequences can be used in transformation vectors to produce transgenic plants which will express the heterologous genes preferentially in tissue, particularly in the roots of maize plants.Type: GrantFiled: May 25, 1995Date of Patent: August 11, 1998Assignee: Novartis Finance CorporationInventor: Annick J. de Framond
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Patent number: 5792904Abstract: Methods are provided for selecting parental plants having disease resistance and for using these plants in breeding programs. In one method of the invention, lesion mimic mutants are screened for either resistance to a pathogen of interest or for the expression of systemic acquired resistance (SAR) genes. Such mutants having the desired traits or expressing the desired genes are then used in breeding programs. Parent plants can also be selected based on the constitutive expression of SAR genes. These mutants are phenotypically normal yet exhibit a significant level of disease resistance. Also disclosed are plant mutants that do not express systemic acquired resistance genes even when induced by a pathogen and methods of use for such mutants.Type: GrantFiled: May 16, 1996Date of Patent: August 11, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Scott J. Uknes, Terrence Patrick Delaney, Eric R. Ward, Henry-York Steiner
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Patent number: 5789214Abstract: The present invention provides chemically regulatable DNA sequences capable of regulating transcription of an associated DNA sequence in plants or plant tissues, chimeric constructions containing such sequences, vectors containing such sequences and chimeric constructions, and transgenic plants and plant tissues containing these chimeric constructions. In one aspect, the chemically regulatable DNA sequences of the invention are derived from the 5' region of genes encoding pathogenisis-related (PR) proteins. The present invention also provides anti-pathogenic sequences derived from novel cDNAs coding for PR proteins which can be genetically engineered and transformed into plants to confer enhanced resistance to disease.Type: GrantFiled: May 31, 1995Date of Patent: August 4, 1998Assignee: Novartis Finance CorporationInventors: John A. Ryals, Leslie B. Friedrich, Scott J. Uknes, Eric R. Ward
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Patent number: 5780469Abstract: Plant-protecting active ingredient mixtures having synergistically enhanced action, wherein component I is a compound having plant-immunising action of formula I ##STR1## wherein Z is CN, COOH or a salt thereof, CO--OC.sub.1 --C.sub.4 alkyl or CO--SC.sub.1 --C.sub.4 alkyl;and wherein component II is a compound selected from the groupA) 4-?3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)acryloyl!morpholine ("dimethomorph");B) 5-methyl-1,2,4-triazolo?3,4-b!?1,3!benzothiazole ("tricyclazole"); andC) 3-allyloxy-1,2-benzothiazole-1,1-dioxide ("probenazole").Type: GrantFiled: December 6, 1996Date of Patent: July 14, 1998Assignee: Novartis Finance CorporationInventor: Wilhelm Ruess