Abstract: Compositions for promoting intestinal health are disclosed and described. In one example, the composition can include a combination of cyanidins and delphinidins, in an amount sufficient to treat intestinal hyperpermeability. In a further example, the composition can further comprise a prebiotic blend and fructooligosaccharides. Further presented herein, is a method of treating a condition or disorder related to gastrointestinal health in a subject. In one example, the method can include maximizing tight junction integrity in epithelial cells of gastrointestinal tract of the subject.

Abstract: Methods for stimulating in-vitro Paecilomyces hepiali or Hirsutella sinensis growth, and nutritional supplement formulations containing such fungal strains are disclosed and described. In some embodiments, such a method may include providing a an effective amount of a P. hepiali fungus strain for use as a stimulating agent on a culture medium for which H. sinensis is grown and regulating the temperature to induce and maintain the growth of the H. sinensis fungus. Alternatively, a P. hepiali fungus may be grown in a similar manner using H. sinensis as the stimulating agent. In some aspects, the growth of one fungus may be sequentially switched with the other in order to improve fungi potency.

Abstract: A device for delivery of TENS current or electrostimulation has a first skin contact electrode mounted on a first non-conductive fingertip base and having at least one contact area for current-bearing contact with skin and a connection to a TENS current source and has a second skin contact electrode, mounted on a non-conductive fingertip base that is the same as the first non-conductive fingertip base or is a second non-conductive fingertip base and having at least one contact area for current-bearing contact with skin and a connection to TENS current source. A control and power unit that supplies TENS current to flow through skin contacting and positioned between the first and second electrodes, and enables selecting the level of the current or energy supplied.

Abstract: Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.

Abstract: An oral formulation includes a plurality of agents that promote cellular detoxification. Agents can be included that modulate expression of Nrf2-associated genes upon ingestion of the oral formulation by a subject, wherein the Nrf2-associated genes include at least one gene encoding intrinsic antioxidants, and at least one gene encoding cellular detoxifiers. In addition, at least one of the plurality of agents attenuates inflammation.

Abstract: A cleansing device for mammalian skin includes a cleansing head having a plurality of elastomeric cleansing features extending away from a first surface of the cleansing head. The cleansing head is attached to a handle. The cleansing device includes an actuator coupled to a rotating drive shaft and adapted to apply oscillating movement to one or more cleansing head sections of the cleansing head at a frequency of about 5 Hz to 30 Hz.

Abstract: A cleansing device for mammalian skin includes a cleansing head having a plurality of elastomeric cleansing features extending away from the first surface and having an aspect ratio of about 1:5 to 10:1. The cleansing head is attached to a handle adapted to apply oscillating movement to one or more cleansing head sections to provide a total displacement per oscillation of about 2 mm to 8 mm at a frequency of about 5 Hz to 30 Hz.

Abstract: A device for delivery of TENS current, attachable to a handheld skin treatment device with a mechanical motion source, comprises a housing for mounting on the handheld skin treatment device, with a conductive skin contact head with first and second electrodes for receiving a TENS signal as a voltage established between the electrodes and a connector mounted in or on the housing and configured to interface with the mechanical motion source to receive the motion of the motion source. The device has an energy converter in the housing to convert the motion into electrical current, a power control circuit for receiving the electrical current and converting it into at least one power supply output voltage; and a signal generation circuit connected to the at least one the power supply output voltage for producing as an output a TENS signal for delivery to skin.

Abstract: Compositions for promoting intestinal health are disclosed and described. In one example, the composition can include a combination of cyanidins and delphinidins, in an amount sufficient to treat intestinal hyperpermeability. In a further example, the composition can further comprise a prebiotic blend and fructooligosaccharides. Further presented herein, is a method of treating a condition or disorder related to gastrointestinal health in a subject. In one example, the method can include maximizing tight junction integrity in epithelial cells of gastrointestinal tract of the subject.

Abstract: Methods for the preparation of nanosized nutrient formulations for enhanced absorption of nutritional agents. The methods include the complexation of cyclodextrin with carotenoids and incorporation of the complexes into the nutritional supplements without intermediate collection, isolation, and drying steps.

Abstract: A cleansing device for mammalian skin includes a cleansing head having a plurality of elastomeric cleansing features extending away from a first surface of the cleansing head. The cleansing head is attached to a handle. The cleansing device includes an actuator coupled to a rotating drive shaft and adapted to apply oscillating movement to one or more cleansing head sections of the cleansing head at a frequency of about 5 Hz to 30 Hz.

Abstract: Systems and methods of weight management and compositions or formulations useful therein are disclosed and described.

Abstract: Methods for controlling estrogen metabolite formation in a subject and compositions for use therein are disclosed and described. In one aspect, estrogen metabolite formation may be controlled by coadministering an effective amount of a phytoestrogen and an indole compound.

Abstract: A method is provided for characterizing a lipofilling agent causing increased lipofilling activity in adipose tissue from a target body area. Such a method can include obtaining a plurality of distinct preadipocyte cultures taken from a plurality of distinct body areas of an individual, exposing the plurality of distinct preadipocyte cultures to a plurality of potential lipofilling agents, culturing the plurality of distinct preadipocyte cultures through differentiation to form a plurality of distinct adipocyte cultures, measuring a degree of lipofilling activity of adipocytes from each of the plurality of distinct adipocyte cultures, and quantifying the measured lipofilling activity across the plurality of distinct adipocyte cultures to identify a lipofilling agent causing increased lipofilling activity in adipose tissue from the target body area as compared to adipose tissue in the non-target body area.

Abstract: Methods for controlling estrogen metabolite formation in a subject and compositions for use therein are disclosed and described. In one aspect, estrogen metabolite formation may be controlled by coadministering an effective amount of a phytoestrogen and an indole compound.

Abstract: A cleansing device for mammalian skin includes a cleansing head having a plurality of elastomeric cleansing features extending away from the first surface and having an aspect ratio of about 1:5 to 10:1. The cleansing head is attached to a handle adapted to apply oscillating movement to one or more cleansing head sections to provide a total displacement per oscillation of about 2 mm to 8 mm at a frequency of about 5 Hz to 30 Hz.