Abstract: The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and/or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.
Type:
Grant
Filed:
October 26, 2012
Date of Patent:
December 1, 2015
Assignee:
NUSIRT SCIENCES, INC.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II
Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Type:
Grant
Filed:
June 22, 2015
Date of Patent:
December 1, 2015
Assignee:
NUSIRT SCIENCES, INC.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Type:
Grant
Filed:
April 19, 2013
Date of Patent:
July 7, 2015
Assignee:
NUSIRT SCIENCES, INC.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Type:
Application
Filed:
April 19, 2013
Publication date:
May 29, 2014
Applicant:
NuSirt Sciences, Inc.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Type:
Grant
Filed:
July 13, 2012
Date of Patent:
January 7, 2014
Assignee:
Nusirt Sciences, Inc.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
Abstract: Compositions and methods useful for inducing an increase in fatty acid oxidation or mitochondrial biogenesis, reducing weight gain, inducing weight loss, or increasing Sirt1, Sirt3, or AMPK activity are provided herein. Such compositions can contain synergizing amounts of a sirtuin-pathway activators, including but not limited to resveratrol, in combination with beta-hydroxymethylbutyrate (HMB), keto isocaproic acid (KIC), leucine, or combinations of HMB, KIC and leucine.
Type:
Grant
Filed:
July 13, 2012
Date of Patent:
December 31, 2013
Assignee:
Nusirt Sciences, Inc.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II, Antje Bruckbauer
Abstract: The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and/or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.
Type:
Application
Filed:
October 26, 2012
Publication date:
September 12, 2013
Applicant:
NuSirt Sciences, Inc.
Inventors:
Michael Zemel, E. Douglas Grindstaff, II