Patents Assigned to Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital
  • Non-ionic, low osmolar contrast agents for delivery of antisense oligonucleotides and treatment of disease
    Patent number: 9725716
    Abstract: Disclosed are compositions comprising an antisense oligonucleotide and a non-ionic, low-osmolar contrast agent. Also disclosed are methods of delivering an antisense oligonucleotide to a target sire comprising incorporating the antisense oligonucleotide into a composition comprising a non-ionic, low-osmolar contrast agent. Also disclosed are methods of treating a neurodegenerative disease comprising administering one or more of the compositions disclosed herein.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: August 8, 2017
    Assignee: Ohio State Innovation Foundation and Research Institute at Nationwide Children's Hospital
    Inventors: Arthur Burghes, Paul Porensky, Brian Kaspar