Patents Assigned to OHMX CORPORATION
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Patent number: 9880121Abstract: In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system.Type: GrantFiled: April 29, 2015Date of Patent: January 30, 2018Assignee: OHMX CorporationInventors: Yijia Paul Bao, Adam G. Gaustad, Dimitra Georganopoulou, Fang Lai, Rebecca Hoo
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Patent number: 9624522Abstract: The disclosure also relates to novel compositions and methods for the single, direct detection of Hemoglobin A1c percentage in a sample, using conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, Eo1 and Eo2.Type: GrantFiled: October 17, 2012Date of Patent: April 18, 2017Assignee: OHMX CorporationInventors: Adam Gaustad, Yijia Paul Bao, Dimitra Georganopoulou
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Publication number: 20160377607Abstract: The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.Type: ApplicationFiled: June 28, 2016Publication date: December 29, 2016Applicant: OHMX CorporationInventors: Yijia Paul Bao, Adam G. Gaustad
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Patent number: 9416390Abstract: This invention describes methods for detecting target analytes by utilizing an electroactive moiety (EAM) that functions as a substrate for a specific enzyme. If target analyte is present, a functional group is enzymatically removed from a transition metal complex resulting in quantifiable electrochemical signal at two unique potentials, E01 and E02 that is detected through a self-assembled monolayer (SAM) on an electrode.Type: GrantFiled: July 26, 2013Date of Patent: August 16, 2016Assignee: OHMX CorporationInventors: Adam G. Gaustad, Michael J. Ahrens, Paul A. Bertin
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Patent number: 9404883Abstract: The disclosure relates to novel methods for performing a solution based assay reaction with an electroactive active moiety (EAM) that subsequently forms a self-assembled monolayer (SAM) utilizing the advantages of faster solution reaction kinetics, SAM protected electrode and surface based electrochemistry for electronic measurement.Type: GrantFiled: July 26, 2013Date of Patent: August 2, 2016Assignee: OHMX CorporationInventors: Yijia Paul Bao, Adam G. Gaustad
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Publication number: 20160202203Abstract: The disclosure also relates to novel methods for detection of biological targets using amplification steps in conjunction with conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, Eo1 and Eo2.Type: ApplicationFiled: December 18, 2015Publication date: July 14, 2016Applicant: OHMX CorporationInventors: Paul A. Bertin, Michael J. Ahrens
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Publication number: 20160178562Abstract: Competitive assays are provided for the detection and quantification of a target analyte utilizing a modified electro-active moiety and an enzyme, in which the target analyte and a target analog moiety are substrates. This method may be used to detect and/or quantify many classes of biological molecules and has a number of applications, e.g., in vitro diagnostic assays and devices.Type: ApplicationFiled: December 18, 2015Publication date: June 23, 2016Applicant: OHMX CorporationInventor: Adam G. Gaustad
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Patent number: 9340567Abstract: The invention relates to novel compositions of 1,3-disubstituted ferrocenes useful for the modification of electrodes.Type: GrantFiled: November 2, 2012Date of Patent: May 17, 2016Assignee: OHMX CorporationInventors: Paul A. Bertin, Michael J. Ahrens
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Publication number: 20160097082Abstract: Methods for predicting the outcome of and monitoring prostate cancer patients using prostate specific antigen (PSA) proteolytic activity (PPA) in combination with other molecular biomarkers or other parameters are described. Methods of determining sets of parameters for use in predicting the outcome of and monitoring of prostate cancer patients are also described.Type: ApplicationFiled: September 23, 2015Publication date: April 7, 2016Applicant: OHMX CorporationInventor: Dimitra Georganopoulou
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Patent number: 9250234Abstract: Described are methods for detecting a target analyte in a test sample by providing a solid support comprising an electrode comprising: (i) a self-assembled monolayer (SAM), (ii) a covalently attached electroactive active moiety (EAM) comprising a transition metal complex comprising a self-immolative moiety and a peroxide sensitive moiety (PSM), wherein said EAM has a first E0; then contacting the target analyte and said solid support under conditions wherein said target analyte reacts with a peroxide generating enzyme to generate peroxide and said self-immolative moiety is removed such that said EAM has a second E0 test sample; and then detecting said second E0 as an indication of the presence of said target analyte. Also provided are compositions for use in the preceding methods.Type: GrantFiled: January 19, 2012Date of Patent: February 2, 2016Assignee: OHMX CorporationInventors: Paul A. Bertin, Michael J. Ahrens
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Patent number: 9250203Abstract: The disclosure also relates to novel methods for detection of biological targets using amplification steps in conjunction with conversion of functional groups attached to a transitional metal complex, resulting in quantifiable electrochemical signal at two unique potentials, E°1 and E°2.Type: GrantFiled: January 9, 2013Date of Patent: February 2, 2016Assignee: OHMX CorporationInventors: Paul A. Bertin, Michael J. Ahrens
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Patent number: 9194836Abstract: The present invention is directed to electronic methods of detecting target analytes such that upon binding of the target analyte a shift in electrochemical potential is seen. This assay relies on the use of an electroactive moiety (“EAM”) that is attached to an electrode and comprises a self-immolative moiety, whose presence gives the EAM a first E0, and whose absence, upon irreversible cleavage gives the EAM a second E0. This difference is detected, and if such change occurs, it is an indication of the presence of a target analyte.Type: GrantFiled: March 11, 2013Date of Patent: November 24, 2015Assignee: OHMX CorporationInventor: Paul A. Bertin
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Publication number: 20150323484Abstract: In one aspect, a method for detection of a target in a sample based on the change of electrochemical cyclic voltammetry peak profile is provided. The method may involve at least two or more electroactive moieties (EAMs) comprising a transitional metal complex and an anchor group. Said transitional metal complex may be capable of reversibly or semi-reversibly transferring one or more electrons. Said anchor group may allow said EAMs to covalently attach to a solid support, forming a self-assembled monolayer (SAM) on the surface. At least one EAM may further comprises a capture ligand that can be recognized and bound by a target or a surrogate target. When a sample is introduced to an EAM, the interaction between said capture ligand and said target or surrogate target may lead to change of the properties of the SAM containing all EAMs involved. Said change can be detected by an electrochemical detection system.Type: ApplicationFiled: April 29, 2015Publication date: November 12, 2015Applicant: OHMX CorporationInventors: Yijia Paul Bao, Adam G. Gaustad, Dimitra Georganopoulou, Fang Lai, Rebecca Hoo
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Publication number: 20150198552Abstract: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.Type: ApplicationFiled: April 16, 2014Publication date: July 16, 2015Applicant: OHMX CorporationInventors: Michael J. Ahrens, Paul A. Bertin, Amanda Eckermann, Dimitra Georganopoulou, Harry B. Gray, Markus Franz Wunder
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Publication number: 20150192538Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.Type: ApplicationFiled: January 9, 2015Publication date: July 9, 2015Applicant: OHMX CORPORATIONInventors: MICHAEL J. AHRENS, PAUL A. BERTIN, HARRY B. GRAY, THOMAS J. MEADE
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Patent number: 8951400Abstract: The invention relates to novel compositions of disubstituted bipyridyl osmium complexes useful for the synthesis of labeled proteins, nucleic acids, and for the modification of electrodes.Type: GrantFiled: July 20, 2011Date of Patent: February 10, 2015Assignee: OHMX CorporationInventors: Michael Ahrens, Paul A. Bertin, Harry B. Gray, Thomas J. Meade
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Publication number: 20140342383Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.Type: ApplicationFiled: May 19, 2014Publication date: November 20, 2014Applicant: OHMX CorporationInventors: Paul A. Bertin, Michael J. Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder
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Publication number: 20140322740Abstract: The present invention is directed to the diagnosis of cancer associated with enzymatically active PSA in samples.Type: ApplicationFiled: March 13, 2013Publication date: October 30, 2014Applicants: NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT FOR PROFIT CORPORATION, OHMX CORPORATIONInventors: OHMX CORPORATION, NORTHWESTERN UNIVERSITY, AN ILLINOIS NOT FOR PROFIT CORPORATION
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Publication number: 20140311922Abstract: The invention relates to novel compositions and methods for the detection of analytes using the nuclear reorganization energy, ?, of an electron transfer process.Type: ApplicationFiled: April 16, 2014Publication date: October 23, 2014Applicant: OHMX CorporationInventors: Michael J. Ahrens, Paul A. Bertin, Amanda Eckermann, Dimitra Georganopoulou, Harry B. Gray, Markus Franz Wunder
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Patent number: 8802390Abstract: The invention relates to novel compositions and methods for the detection of enzymes using the nuclear reorganization energy, ?, of an electron transfer process.Type: GrantFiled: January 18, 2012Date of Patent: August 12, 2014Assignee: OHMX CorporationInventors: Paul A. Bertin, Michael Ahrens, Dimitra Georganopoulou, Harry B. Gray, Thomas J. Meade, Markus Franz Wunder