Abstract: A method and medical preparation for enhancing tissue oxygenation by suppression of a hypoxia induced factor 1? (HIF-1?) in case of low oxygen tension in a tissue of a diabetic foot in a patient with type I or type II diabetes mellitus, wherein the method includes administering a dipeptide of L-glutamic acid-L-tryptophan (L-Glu-L-Trp), and wherein the medical preparation includes an effective amount of the dipeptide of L-Glu-L-Trp as an active agent and a pharmaceutically acceptable carrier. Moreover, the method can include administering the medical preparation in a dose of 1.0 ?g per kg-10.0 ?g per kg of body weight at least once a day for a period necessary to achieve a therapeutic effect.