Patents Assigned to Oncomembrane
  • Trimethylsphingosine derivatives
    Patent number: 6031135
    Abstract: The invention relates to trimethylsphingosine derivatives which have some or all of the activities of the parent compound.
    Type: Grant
    Filed: May 13, 1996
    Date of Patent: February 29, 2000
    Assignee: Oncomembrane, Inc.
    Inventors: Fuqiang Ruan, Yasuyuki Igarashi, Sen-Itiroh Hakomori
  • Plasmalopsychosines and plasmalocerebrosides
    Patent number: 5693620
    Abstract: An isolated plasmalopsychosine selected from the group consisting of compound A and compound B: ##STR1## wherein n1 is 0-50 or an isolated synthetic plasmalocerebroside selected from the group consisting of compound C and compound D: ##STR2## wherein n2 and n3 each is 0-50.
    Type: Grant
    Filed: December 12, 1994
    Date of Patent: December 2, 1997
    Assignee: Oncomembrane, Inc.
    Inventors: Edward Nudelman, Sen-Itiroh Hakomori, Steven B. Levery, Yasuyuki Igarashi, Khalid Sadozai
  • Method for quantifying sphingosine and for diagnosing platelet activation
    Patent number: 5677189
    Abstract: A method of detecting sphingosines and platelet activation is disclosed.
    Type: Grant
    Filed: June 29, 1995
    Date of Patent: October 14, 1997
    Assignee: Oncomembrane, Inc.
    Inventors: Yasuyuki Igarashi, Yutaka Yatomi, Hideki Ohta, Sen-Itiroh Hakomori
  • Sphingosine-1-phosphate essentially free of L-threo isomer
    Patent number: 5663404
    Abstract: A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent.
    Type: Grant
    Filed: January 12, 1995
    Date of Patent: September 2, 1997
    Assignee: Oncomembrane
    Inventors: Yasuyuki Igarashi, Fuqiang Ruan, Yoshito Sadahira, Shigeyuki Kawa, Sen-itiroh Hakomori
  • Sphingosine-1-phosphate/trimethylsphingosine composition
    Patent number: 5627171
    Abstract: Sphingosine-1-phosphate/N,N,N-trimethylsphingosine composition to modulate cell growth.
    Type: Grant
    Filed: April 11, 1994
    Date of Patent: May 6, 1997
    Assignee: Oncomembrane, Inc.
    Inventors: Yong S. Park, Yasuyuki Igarashi, Sen-itiroh Hakomori