Patents Assigned to Oraya Therapeutics, Inc.
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Patent number: 7792249Abstract: Embodiments provide method and systems for determining alignment of a patient's body part, such as an eye, in an external coordinate system of a treatment or diagnostic device, such as a radiotherapy device, so as to define a reference axis for guiding device operation. Additional embodiments provide image-based methods and systems for aligning, tracking and monitoring motion of a body part and a treatment target in relation to a radiation beam axis. Particular ophthalmic embodiments provide method and systems including an eye-contact guide device and imaging system for aligning and tracking motion of an eye and ocular treatment target in relation to an orthovoltage X-ray beam axis, so as to monitor application of radiation to a lesion, such as a macular lesion of the retina.Type: GrantFiled: December 18, 2008Date of Patent: September 7, 2010Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Matt Herron, Igor Koruga, Junzhong Liang
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Publication number: 20100195794Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system.Type: ApplicationFiled: April 6, 2010Publication date: August 5, 2010Applicant: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Publication number: 20100172473Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system.Type: ApplicationFiled: March 16, 2010Publication date: July 8, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Erik Chell, Steven D. Hansen, Mark Arnoldussen, Matt Herron, Kuang-Hung Pan
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Publication number: 20100166148Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: ApplicationFiled: June 26, 2009Publication date: July 1, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell, Mark Arnoldussen, Matt Herron
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Patent number: 7697663Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: January 31, 2008Date of Patent: April 13, 2010Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Patent number: 7693259Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: February 1, 2008Date of Patent: April 6, 2010Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Patent number: 7693258Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: January 31, 2008Date of Patent: April 6, 2010Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Patent number: 7693260Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: April 9, 2008Date of Patent: April 6, 2010Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen
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Publication number: 20100067656Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: ApplicationFiled: August 5, 2009Publication date: March 18, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell
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Publication number: 20100067657Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: ApplicationFiled: August 7, 2009Publication date: March 18, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell
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Publication number: 20100067658Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilised in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: ApplicationFiled: August 7, 2009Publication date: March 18, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell
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Patent number: 7680245Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system based on ocular imaging. In some embodiments, the ocular structures inside the global coordinate system lead to direction of an automated positioning system that is directed based on the ocular structures within the coordinate system. In some embodiments, the position of the ocular structure is tracked and related to the status of the radiosurgery system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, the structure is an eye and the eye is tracked by the system.Type: GrantFiled: January 31, 2008Date of Patent: March 16, 2010Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Patent number: 7680244Abstract: A radiosurgery system is described that delivers a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, ocular structures are placed in a global coordinate system, based on ocular imaging, which leads to direction of an automated positioning system. In some embodiments, the position of an ocular structure is tracked and related to a radiosurgery system. In some embodiments, a treatment plan is utilized for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial aids in positioning the system. In some embodiments, a reflection off the eye is used to aid in positioning. In some embodiments, radiodynamic therapy is described in which radiosurgery is used in combination with other treatments and can be delivered concomitant with, prior to, or following other treatments.Type: GrantFiled: October 16, 2007Date of Patent: March 16, 2010Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Erik Chell, Steven D. Hansen, Mark Arnoldussen, Matt Herron, Kuang-Hung Pan
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Publication number: 20100002837Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: ApplicationFiled: July 2, 2009Publication date: January 7, 2010Applicant: Oraya Therapeutics, Inc.Inventors: Michael GERTNER, Steven D. Hansen
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Patent number: 7620147Abstract: A radiosurgery system is described that is configured to deliver a therapeutic dose of radiation to a target structure in a patient. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, other disorders or tissues of a body are treated with the dose of radiation. In some embodiments, the target tissues are placed in a global coordinate system based on ocular imaging. In some embodiments, the target tissues inside the global coordinate system lead to direction of an automated positioning system that is directed based on the target tissues within the coordinate system. In some embodiments, a treatment plan is utilized in which beam energy and direction and duration of time for treatment is determined for a specific disease to be treated and/or structures to be avoided. In some embodiments, a fiducial marker is used to identify the location of the target tissues.Type: GrantFiled: December 13, 2007Date of Patent: November 17, 2009Assignee: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Steven D. Hansen, Erik Chell
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Patent number: 7564946Abstract: A radiosurgery system configured to deliver a therapeutic dose of radiation to a target structure in a patient is described. In some embodiments, inflammatory ocular disorders are treated, specifically macular degeneration. In some embodiments, the ocular structures are placed in a global coordinate system, and these ocular structures are used to direct an automated positioning system. In some embodiments, the position of ocular structures is tracked and related to the status of the radiosurgery system, and a treatment plan is utilized in which beam energy, direction, and duration of treatment is determined and/or structures to be avoided. In some embodiments, an eye is tracked by the system. The eye can be held in place, and the eye can be fixed by the patient. In some embodiments, a fiducial is placed on the eye to aid in positioning, or a reflection off the eye is used to aid in positioning.Type: GrantFiled: January 31, 2008Date of Patent: July 21, 2009Assignee: Oraya Therapeutics, Inc.Inventor: Michael Gertner
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Publication number: 20090182310Abstract: A method and system for performing an ocular irradiation procedure on a patient's eye is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device attachable to the front portion of the patient's eye, to stabilize the position of the eye; and a position detector for determining the position of the contact device in the external coordinate system. A source of a collimated electromagnetic radiation beam in the system is controlled by a beam-positioning assembly for positioning the beam source such that the beam, when activated, is aimed along a selected path at a selected coordinate in the external coordinate system corresponding to a selected target region in the patient's eye.Type: ApplicationFiled: February 6, 2008Publication date: July 16, 2009Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Publication number: 20090182312Abstract: An eye contact device and assembly for stabilizing a human eye at a selected position in an external coordinate system is disclosed. The device includes an eye-contact member having an inner contact surface for contacting a front surface of an eye, and a vacuum port formed within the eye-contact member by which a negative pressure can be applied between the eye and the contact surface, to stabilize the position of the eye with respect to the device. The device, which is adapted to be biased against the patient's eye, to secure the device to the eye, may be pivotally coupled to a positioning arm, and may carry one or more beam-directing elements by which the position of the device in an external coordinate system can be determined.Type: ApplicationFiled: February 6, 2008Publication date: July 16, 2009Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Publication number: 20090182311Abstract: A system for securing a patient eye at a known position in an external coordinate system is disclosed. The system includes a head support for supporting the patient's head, an eye-contact device including a concave contact surface adapted to be placed against the front surface of a patient's eye, and a port in fluid communication with the contact surface, by which a vacuum can be applied to the device to remove air between the eye and the contact surface, to stabilize the position of the eye with respect to the contact device, and a biasing mechanism operatively connected to the contact device for biasing the contact device against the eye with a force sufficient to the hold the contact device against the eye, when the eye is stabilized with respect to the device by removal of air between the eye and the device's contact surface.Type: ApplicationFiled: February 6, 2008Publication date: July 16, 2009Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Matt Herron
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Publication number: 20090161826Abstract: A method, code and system for planning the treatment a lesion on or adjacent to the retina of an eye of a patient are disclosed. There is first established at least two beam paths along which x-radiation is to be directed at the retinal lesion. Based on the known spectral and intensity characteristics of the beam, a total treatment time for irradiation along each beam paths is determined. From the coordinates of the optic nerve in the aligned eye position, there is determined the extent and duration of eye movement away from the aligned patient-eye position in a direction that moves the patient's optic nerve toward the irradiation beam that will be allowed during treatment, while still maintaining the radiation dose at the patient optic nerve below a predetermined dose level.Type: ApplicationFiled: October 30, 2008Publication date: June 25, 2009Applicant: Oraya Therapeutics, Inc.Inventors: Michael Gertner, Mark Arnoldussen, Erik Chell, Steven D. Hansen, Junzhong Liang