Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
Type:
Application
Filed:
August 4, 2023
Publication date:
March 7, 2024
Applicant:
Orca Biosystems, Inc.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
Type:
Grant
Filed:
September 12, 2022
Date of Patent:
September 19, 2023
Assignee:
Orca Biosystems, Inc.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
Type:
Grant
Filed:
June 16, 2020
Date of Patent:
October 18, 2022
Assignee:
Orca Biosystems, Inc.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
December 8, 2020
Assignee:
ORCA BIOSYSTEMS, INC.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan
Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
Type:
Grant
Filed:
May 29, 2019
Date of Patent:
July 28, 2020
Assignee:
ORCA BIOSYSTEMS, INC.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
Abstract: This disclosure provides methods and apparatuses for sorting target particles. In various embodiments, the disclosure provides a cassette for sorting target particles, methods for sorting target particles, methods of loading a microchannel for maintaining sample material viability, methods of quantifying sample material, and an optical apparatus for laser scanning and particle sorting.
Type:
Grant
Filed:
July 24, 2018
Date of Patent:
July 16, 2019
Assignee:
Orca Biosystems, Inc.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Lagnajeet Pradhan
Abstract: The present disclosure provides distinct therapeutic populations of cells that form a pharmaceutical composition useful in hematopoietic stem/progenitor cell transplant. For example, the present disclosure provides a therapeutic population of cells, comprising an enriched population of hematopoietic stem/progenitor cells, memory T cells, regulatory T cells, and wherein the population of cells is depleted of naïve conventional ??-T cells. The present disclosure further provides methods of treatment using the therapeutic population of cells. In other embodiments, the present disclosure provides methods of producing a therapeutic population of cells.
Type:
Grant
Filed:
March 15, 2018
Date of Patent:
May 28, 2019
Assignee:
Orca Biosystems, Inc.
Inventors:
Ivan K. Dimov, Nathaniel Fernhoff, Kevin Sheehan