Patents Assigned to ORGENESIS LTD.
  • Methods of transdifferentiation and methods of use thereof
    Patent number: 11617769
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: April 1, 2020
    Date of Patent: April 4, 2023
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • Transdifferentiated cell populations and methods of use thereof
    Patent number: 10975354
    Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic ?-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic ?-cell phenotype and function.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: April 13, 2021
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • Cell populations, methods of transdifferentiation and methods of use thereof
    Patent number: 10947509
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Grant
    Filed: April 25, 2018
    Date of Patent: March 16, 2021
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20200297777
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Application
    Filed: April 1, 2020
    Publication date: September 24, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Methods of transdifferentiation and methods of use thereof
    Patent number: 10668107
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: June 2, 2020
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • TRANSDIFFERENTIATED CELL POPULATIONS AND METHODS OF USE THEREOF
    Publication number: 20200140825
    Abstract: Disclosed herein are methods for manufacturing transdifferentiated populations of non-pancreatic human insulin producing cells, and methods for enriching populations of non-pancreatic ?-cells for cells comprising an enriched capacity for transcription factor-induced transdifferentiation into a pancreatic ?-cell phenotype and function.
    Type: Application
    Filed: November 7, 2019
    Publication date: May 7, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY
    Publication number: 20200109370
    Abstract: Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function and a scaffold, wherein said transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to a 3D cell cluster without a scaffold and to similarly transdifferentiated cells cultured as a two-dimensional (2D) monolayer.
    Type: Application
    Filed: May 27, 2018
    Publication date: April 9, 2020
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20190134097
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Application
    Filed: November 29, 2018
    Publication date: May 9, 2019
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Methods of transdifferentiation and methods of use thereof
    Patent number: 10179151
    Abstract: Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic ?-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: January 15, 2019
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber
  • CELL POPULATIONS, METHODS OF TRANSDIFFERENTIATION AND METHODS OF USE THEREOF
    Publication number: 20180340146
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Application
    Filed: April 25, 2018
    Publication date: November 29, 2018
    Applicants: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah FERBER
  • Cell populations, methods of transdifferentiation and methods of use thereof
    Patent number: 9982236
    Abstract: The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic ?-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: May 29, 2018
    Assignees: ORGENESIS LTD., TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
    Inventor: Sarah Ferber