Patents Assigned to Original Biomedicals, Co., Ltd.
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Patent number: 9795677Abstract: The present invention features a method for reducing the damage caused by free radicals, the method comprises administering a pharmaceutical composition that comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier to a subject. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.Type: GrantFiled: June 8, 2017Date of Patent: October 24, 2017Assignee: ORIGINAL BIOMEDICALS CO., LTDInventors: Chia-Hung Chen, Chau-Hui Wang, John-Son Lin, Tieh-Hsiung Chiu, Jing-Yi Chen, Pi-Hung Liao, Chia-Chi Su, Wei-Chuan Liao
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Patent number: 9700623Abstract: The present invention features a pharmaceutical composition used for reducing the damage caused by free radicals, which comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and may be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.Type: GrantFiled: November 22, 2012Date of Patent: July 11, 2017Assignee: ORIGINAL BIOMEDICALS CO., LTD.Inventors: Chia-Hung Chen, Chau-Hui Wang, John-Son Lin, Tieh-Hsiung Chiu, Jing-Yi Chen, Pi-Hung Liao, Chia-Chi Su, Wei-Chuan Liao
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Patent number: 9597406Abstract: This invention provides the controlled-release method for a pharmaceutical composition comprising of metals in the drug carrier. The specific chelator is used to trigger the release of active pharmaceutical ingredients from chelating complex micelles. The drug release rate and half-life can also be controlled by manipulating the dosing sequence and the concentration of metal and specific chelator.Type: GrantFiled: January 31, 2013Date of Patent: March 21, 2017Assignee: ORIGINAL BIOMEDICALS CO., LTDInventors: Chia-Hung Chen, Chau-Hui Wang, John-Son Lin, Tieh-Hsiung Chiu, Jing-Yi Chen, Pi-Hung Liao, Chia-Chi Su, Wei-Chuan Liao
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Patent number: 9226967Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: GrantFiled: June 17, 2014Date of Patent: January 5, 2016Assignee: ORIGINAL BIOMEDICALS CO., LTDInventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
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Patent number: 9220786Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: GrantFiled: June 17, 2014Date of Patent: December 29, 2015Assignee: ORIGINAL BIOMEDICALS CO., LTDInventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
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Patent number: 9211341Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: GrantFiled: June 17, 2014Date of Patent: December 15, 2015Assignee: ORIGINAL BIOMEDICALS CO., LTD.Inventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
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Publication number: 20150290321Abstract: The present invention features a pharmaceutical composition used for reducing the damage caused by free radicals, which comprises at least a metal or its ions, at least a drug or an antioxidant that is carrier-protected/modified, and a drug carrier. Said carrier helps to preserve the anti-oxidative activity, and hence, prevents the decrease of the effect of the antioxidant against free radicals produced in the environment or body fluids and prolongs protection, and may be used for reducing damage caused by radiation and adverse effects induced by chemotherapeutic drugs.Type: ApplicationFiled: November 22, 2012Publication date: October 15, 2015Applicant: Original BioMedicals Co., LtdInventors: Chia-Hung Chen, Chau-Hui Wang, John-Son Lin, Tieh-Hsiung Chiu, Jing-Yi Chen, Pi-Hung Liao, Chia-Chi Su, Wei-Chuan Liao
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Patent number: 8785569Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: GrantFiled: November 21, 2012Date of Patent: July 22, 2014Assignee: Original Biomedicals Co., Ltd.Inventors: Chau-Hui Wang, Chia-Hung Chen, Johnson Lin, Jing-Yi Chen, Wei-Chuan Liao
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Publication number: 20130131283Abstract: This invention provides Chelating Complex Micelles as a drug carrier. The Chelating Complex Micelles can load drugs without changing their structure, and therefore extend the half-life of drugs in the human body. The chelating complex micelles contain a metal ion core, at least one polymer, and at least one drug molecule. The metal ion is considered as a Lewis acid while polymer chain and drug molecules are referred to as Lewis bases. The drug molecule is linked to the polymer via forming coordinate bonds with metal ion, and then self-assembled to form chelating complex micelles as a drug carrier.Type: ApplicationFiled: November 21, 2012Publication date: May 23, 2013Applicant: Original Biomedicals, Co., Ltd.Inventor: Original Biomedicals, Co., Ltd.