Patents Assigned to OrthoLogic Corp.
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Patent number: 7935341Abstract: Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed.Type: GrantFiled: September 14, 2006Date of Patent: May 3, 2011Assignee: Orthologic Corp.Inventors: Darrell H. Carney, John S. Bergmann, Gerald M. Fuller
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Patent number: 7919457Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.Type: GrantFiled: October 10, 2008Date of Patent: April 5, 2011Assignee: Orthologic Corp.Inventor: Darrell H. Carney
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Patent number: 7875588Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.Type: GrantFiled: September 25, 2007Date of Patent: January 25, 2011Assignee: Orthologic Corp.Inventors: David W. Hobson, Roger S. Crowther, Darrell H. Carney, Andrew Po Kwan Tang
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Patent number: 7833982Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.Type: GrantFiled: May 23, 2008Date of Patent: November 16, 2010Assignee: Orthologic Corp.Inventor: Darrell H. Carney
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Patent number: 7732411Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.Type: GrantFiled: April 13, 2007Date of Patent: June 8, 2010Assignee: Orthologic Corp.Inventor: Darrell H. Carney
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Publication number: 20090124550Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.Type: ApplicationFiled: October 10, 2008Publication date: May 14, 2009Applicant: OrthoLogic Corp.Inventor: Darrell H. Carney
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Patent number: 7456250Abstract: Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.Type: GrantFiled: December 30, 2004Date of Patent: November 25, 2008Assignee: OrthoLogic Corp.Inventor: Darrell H. Carney
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Patent number: 7378500Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.Type: GrantFiled: April 4, 2006Date of Patent: May 27, 2008Assignee: Orthologic Corp.Inventor: Darrell H. Carney
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Patent number: 7304035Abstract: Disclosed is a method of stimulating bone growth at a site in a subject in need of osteoinduction. The method comprises the step of administering a therapeutically effective amount of an agonist of the non-proteolytically activated thrombin receptor to the site.Type: GrantFiled: January 18, 2005Date of Patent: December 4, 2007Assignee: Orthologic Corp.Inventors: Darrell H. Carney, Roger S. Crowther, David J. Simmons, Jinping Yang, William R. Redin
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Patent number: 7291596Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol-containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non-proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.Type: GrantFiled: December 30, 2004Date of Patent: November 6, 2007Assignee: Orthologic Corp.Inventors: David W. Hobson, Roger S. Crowther, Darrell H. Carney, Andrew Po Kwan Tang
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Patent number: 7214661Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.Type: GrantFiled: December 2, 2005Date of Patent: May 8, 2007Assignee: OrthoLogic Corp.Inventor: Darrell H. Carney
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Patent number: 7049294Abstract: Disclosed is a method of promoting healing of a chronic dermal skin ulcer, such as a diabetic ulcer, on a subject. The method comprises the step of contacting the chronic dermal skin ulcer with an effective amount of an agonist of the non-proteolytically activated thrombin receptor.Type: GrantFiled: January 27, 2004Date of Patent: May 23, 2006Assignee: Orthologic Corp.Inventor: Darrell H. Carney
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Patent number: 7034001Abstract: The present invention relates to a method for promoting cardiac tissue repair comprising administering to the cardiac tissue a therapeutically effective amount of an angiogenic thrombin derivative peptide and/or inhibiting or reducing vascular occlusion or restenosis. The invention also relates to methods of stimulating revascularization. In yet another embodiment, the invention relates to the use of thrombin derivative peptides in the manufacture of a medicament for the methods described herein.Type: GrantFiled: September 30, 2004Date of Patent: April 25, 2006Assignee: OrthoLogic Corp.Inventor: Darrell H. Carney
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Publication number: 20040082885Abstract: A therapeutic mobilization device is disclosed. The device includes a flexion assembly, a pro/supination assembly and a valgus carrying angle compensation device. The flexion assembly has an arm attachment assembly and an elbow actuator and the elbow actuator defines and axes of rotation. The pro/supination assembly is attached to flexion assembly and has a distal forearm attachment assembly and a pro/supination actuator operably connected thereto. The valgus carrying angle compensation device is operably attached to the flexion assembly and the pro/supination assembly. Preferably the pro/supination assembly is slidably mounted on a housing shaft whereby during flexion the pro/supination assembly is free to move along the housing shaft. Further, preferably the arm attachment assembly includes an attachment ring and an adjustable clamp pivotally attached thereto whereby the attachment ring defines a pro/supination axis and the adjustable clamp pivots orthogonally to the pro/supination axis.Type: ApplicationFiled: May 13, 2003Publication date: April 29, 2004Applicant: Orthologic Corp.Inventors: Jeff Culhane, Alex Solomon, Paul Kruger, Dragan Milosavljevic, Dan Cotterell, Andrew MacPhail
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Patent number: 5951499Abstract: A continuous passive motion (CPM) device for the synovial joints and surrounding soft tissue of the human body, more specifically to the upper extremities. The device includes an upper arm support suitably fixed to a drive actuator and a adjustable forearm support attached to the rotational center of the drive actuator so that pivotal movement of the output causes the forearm support to pivot about an axis parallel to a longitudinal axis of the forearm support. Various cuffs are provided so a patient can secure their upper arm above the elbow and the upper forearm below the elbow to the device with the actuator located either forward of or behind the elbow. The rotational motion of pronation and supination is created by aligning the rotational center of the actuator output with the anatomical rotational center of the forearm. The rotational centers are concentric to minimize stresses on the affected limb.Type: GrantFiled: July 29, 1997Date of Patent: September 14, 1999Assignee: Orthologic Corp.Inventors: John H. Saringer, Jeffrey J. Culhane
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Patent number: 5879301Abstract: A method for the assessment of various properties of bone is provided. The method includes applying a pair of ultrasound transducers to skin on opposite sides of the bone and generating an ultrasound signal and directing the signal through both the bone and a known medium to obtain a bone output signal and a reference signal. The method further includes establishing a set of parameters associated with the bone output signal and a set of parameters associated with the reference signal and then subjecting the two sets of parameters to comparative analysis in order to obtain the desired bone property. An apparatus for the assessment of various properties of bone is also provided. The apparatus includes a pair of ultrasound transducers which may be single-element transducers or array transducers in any combination.Type: GrantFiled: July 25, 1997Date of Patent: March 9, 1999Assignee: Orthologic Corp.Inventors: Alessandro Chiabrera, Jonathan J. Kaufman
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Patent number: 5860941Abstract: An active and continuous passive motion (CPM) devices for exercising and/or providing therapy to the upper and lower extremities comprising a frame, a disc pivotally mounted to the frame and hand or feet support members attached to the disc. A motor is provided and is coupled to the disc for rotating the disc in the active mode. A control circuit is provided for adjusting the speed of the disc in the passive mode and for adjusting the resistance to movement of the disc in the active mode.Type: GrantFiled: November 14, 1996Date of Patent: January 19, 1999Assignee: Orthologic Corp.Inventors: John H. Saringer, Jeffrey J. Culhane, Alexander G. Solomon
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Patent number: 5785656Abstract: A method for assessment of bone properties utilizing a new set of ultrasound parameters comprises passing ultrasonic signal through a bone tissue, modeling an output signal and a reference output signal and subjecting said parameters of the models to comparative analysis. Some of the new ultrasound parameters can be determined using analog processing techniques. An apparatus is also disclosed for practicing this method with one embodiment utilizing multi-element, two-dimensional array transducers. In conjunction with said array transducers, a synthetic aperture array mode is also disclosed.Type: GrantFiled: September 6, 1996Date of Patent: July 28, 1998Assignee: OrthoLogic Corp.Inventors: Alessandro Chiabrera, Jonathan J. Kaufman
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Patent number: D345799Type: GrantFiled: December 27, 1991Date of Patent: April 5, 1994Assignee: OrthoLogic Corp.Inventors: Donald R. Lamond, Bert Heinzelman