Patents Assigned to Osaka University
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Publication number: 20240153248Abstract: A storage unit stores therein first inference results respectively corresponding to a plurality of face images, which are output from a first model of outputting a first inference result in response to an input of a face image. A processing unit selects, from the plurality of face images, first and second face images whose distance calculated based their first inference results exceeds a threshold. The processing unit performs machine learning to train a second model of outputting a second inference result in response to an input of a face image, using a third face image obtained by combining the first and second face images.Type: ApplicationFiled: August 1, 2023Publication date: May 9, 2024Applicants: Fujitsu Limited, OSAKA UNIVERSITYInventors: Ryosuke KAWAMURA, Noriko IKEMOTO TAKEMURA, Hajime NAGAHARA
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Publication number: 20240149060Abstract: The electrical stimulation device includes: positive and negative electrodes to be attached to epidermis of agonist-antagonist muscles acting on a target joint; a display unit; an EMG rehabilitation unit that detects an electromyogram of the agonist-antagonist muscles via the electrodes and outputs variation information corresponding to the detected electromyogram to the display unit; a FES rehabilitation unit that instructs motion of the agonist-antagonist muscles via the display unit and outputs a stimulation current signal corresponding to the instructed motion of the agonist-antagonist muscles to the electrodes; a model (inverse model) storage unit that stores models obtained beforehand and relating to target muscle characteristics, the models including: a model for converting the detected electromyogram into the variation information; and a model for converting information on the motion of the agonist-antagonist muscles into the stimulation current signal; and a rehabilitation processing unit that selectType: ApplicationFiled: February 8, 2022Publication date: May 9, 2024Applicant: OSAKA UNIVERSITYInventor: Kazuhiro MATSUI
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Publication number: 20240148775Abstract: An oligonucleotide or a pharmacologically acceptable salt thereof according to the present invention contains a nucleotide sequence complementary to a continuous sequence of at least 12 bases in a target region constituted by a base sequence of SEQ ID No. 1, and induces N-exon skipping in human REST pre-mRNA processing. Such oligonucleotides are useful for manufacturing medicines for treatment of cancer, for example.Type: ApplicationFiled: February 25, 2022Publication date: May 9, 2024Applicant: Osaka UniversityInventors: Masahito SHIMOJO, Satoshi OBIKA, Keishiro MISHIMA, Misa YOSHIDA
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Patent number: 11976062Abstract: The present invention provides a compound, a salt thereof, or a prodrug thereof as a compound effective for preventing and/or treating fibrosis, the compound being represented by formula (1) (wherein A is an optionally substituted benzene ring; B is optionally substituted aryl or optionally substituted heteroaryl; X is an oxygen atom or a sulfur atom; Y is a nitrogen atom or a carbon atom, of Y is a single or double bond when Y is a carbon atom, or of Y is a single bond when Y is a nitrogen atom; each R1 independently represents lower alkyl, or two R1s may be bound to each other to form a spiro ring or a crosslinked structure, or two R1s may be bound to each other to form a saturated fused heterocycle together with nitrogen and carbon atoms constituting a ring containing Y; p is 0, 1, or 2; or (R1)p is oxo).Type: GrantFiled: December 1, 2022Date of Patent: May 7, 2024Assignees: OSAKA UNIVERSITY, KYOTO UNIVERSITY, INTER-UNIVERSITY RESEARCH INSTITUTE CORPORATION NATIONAL INSTITUTES OF NATURAL SCIENCESInventors: Ryu Nagata, Yasuo Mori, Masayuki Mori, Motohiro Nishida, Takuro Tomita
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Patent number: 11977059Abstract: A light source emits excitation light to discharge gas that flows through a dielectric tube. A ground electrode unit includes a first ground electrode and a second ground electrode arranged at a distance from each other in an axial direction of the dielectric tube. A high-voltage electrode is provided between the first ground electrode and the second ground electrode. A first distance between the first ground electrode and the high-voltage electrode is shorter than a second distance between the second ground electrode and the high-voltage electrode. A cover is provided on an outer wall of the dielectric tube at a position between the first ground electrode and the high-voltage electrode. The light source is arranged to emit excitation light such that an optical axis thereof is directed toward a position where the cover is not provided on the outer wall of the dielectric tube.Type: GrantFiled: September 20, 2021Date of Patent: May 7, 2024Assignees: Shimadzu Corporation, OSAKA UNIVERSITYInventors: Kei Shinada, Satoshi Matsuoka, Katsuhisa Kitano
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Publication number: 20240138870Abstract: Grasping forceps include a cylindrical sheath, a shaft furnished inside the sheath, an operation unit provided near a base end of the sheath and sliding the shaft by converting rotating operation force into an axial direction of the shaft through a pin, and a grasping unit provided near a front end of the sheath and enabling upper and lower jaw units to be open and closed. The grasping unit includes a link unit that couples the upper and lower jaw units, and the front end of the shaft through a pin and opens and closes the upper and lower jaw units according to a slide of the shaft, and the link unit, when the upper and lower jaw units are in a closed state, sets facing grasping surfaces to be parallel and have a predetermined gap dimension.Type: ApplicationFiled: December 24, 2021Publication date: May 2, 2024Applicant: OSAKA UNIVERSITYInventors: Ken NAKATA, Takashi KANAMOTO
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Patent number: 11969459Abstract: The present inventors have found that HMGB1 fragment peptides having a particular amino acid sequence exhibit the effects of improvement of cardiac function, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of dilated cardiomyopathy, that the particular HMGB1 fragment peptides also exhibit the effects of improvement of cardiac function, inhibition of cardiomegaly, inhibition of cardiomyocyte hypertrophy, inhibition of myocardial fibrosis, and promotion of angiogenesis in an animal model of ischemic cardiomyopathy caused by old myocardial infarction, and that the particular HMGB1 fragment peptides exhibit the effects of inhibition of cardiomyocyte hypertrophy and inhibition of myocardial fibrosis in an animal model of hypertensive cardiomyopathy.Type: GrantFiled: January 26, 2018Date of Patent: April 30, 2024Assignees: StemRIM Inc., OSAKA UNIVERSITYInventors: Katsuto Tamai, Yoshiki Sawa, Shigeru Miyagawa, Takashi Kido, Takasumi Goto, Takehiko Yamazaki
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Patent number: 11973184Abstract: One or more embodiments of the present invention are to provide a method for producing a composite metal oxide having an excellent crystallinity by a mechanochemical method. One or more embodiments of the present invention relate to a method for producing a garnet-type composite metal oxide containing Li, La, Zr and O. The method includes a step of treating a mixture containing raw material powders and a flux by a mechanochemical method to react the raw material powders, and the raw material powders contain a Li source powder, a La source powder and a Zr source powder. The raw material powders may further contain at least one selected from an Al source powder and a Ga source powder.Type: GrantFiled: February 1, 2021Date of Patent: April 30, 2024Assignees: KANEKA CORPORATION, OSAKA UNIVERSITYInventors: Kazuaki Kanai, Shohei Kitano, Makio Naito
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Publication number: 20240134245Abstract: A liquid crystal element is provided that can inhibit occurrence of voltage drop between one end and the other end of each electrode. A liquid crystal element (100) includes a liquid crystal layer LQ, a plurality of first arcuate electrodes (1), and a plurality of second arcuate electrodes (2). The first arcuate electrodes (1) are disposed concentrically about an optical axis (AX) of the liquid crystal element (100) and applies first voltage (Vi) to the liquid crystal layer (LQ). The second arcuate electrodes (2) are disposed concentrically about the optical axis (AX) and applies second voltage (V2) to the liquid crystal layer (LQ).Type: ApplicationFiled: December 26, 2023Publication date: April 25, 2024Applicant: OSAKA UNIVERSITYInventors: Giichi SHIBUYA, Sunri LEE, Hiroyuki YOSHIDA, Masanori OZAKI
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Patent number: 11965857Abstract: A vibrator that is capable of vibrating without using an electrode and has good detection sensitivity is provided. A carbon-based material vibrator for vibration by light irradiation has a biological substance or a substance capable of identifying a biological substance immobilized on the vibrator. The vibrator may not include a counter electrode for applying a voltage to the vibrator. The carbon-based material may be graphite. A thermal conductivity ?1 in a plane direction of the carbon-based material is 100 times or more than a thermal conductivity ?2 in a thickness direction of the carbon-based material.Type: GrantFiled: April 5, 2021Date of Patent: April 23, 2024Assignees: KANEKA CORPORATION, OSAKA UNIVERSITYInventors: Kensuke Murashima, Mutsuaki Murakami, Hirotsugu Ogi, Koichi Kusakabe
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Patent number: 11964338Abstract: A low-temperature joining method effectively suppresses reductions in the mechanical properties of a junction of various types of high-tensile steel or aluminum, and of a heat-affected zone; and produces a joint structure. A method for joining two metal materials by forming a joint interface in which the two metal materials face each other at a joint portion and plunge a rotation tool caused to rotate at a prescribed speed into the joint, the method for low-temperature joining of metal materials characterized in that the peripheral velocity of the outermost periphery of the rotation tool is set to 51 mm/s or less, whereby the recrystallization temperature inherent to the metal materials is reduced by introducing a large strain to the joint, and recrystallized grains are generated at the joint interface by setting the joining temperature to less than the recrystallization temperature inherent to the metal materials.Type: GrantFiled: February 28, 2017Date of Patent: April 23, 2024Assignee: OSAKA UNIVERSITYInventors: Hidetoshi Fujii, Rintaro Ueji, Yoshiaki Morisada
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Publication number: 20240124898Abstract: A CRISPR-Cas3 system was successfully established in a eukaryotic cell.Type: ApplicationFiled: September 14, 2023Publication date: April 18, 2024Applicant: OSAKA UNIVERSITYInventors: Tomoji MASHIMO, Junji TAKEDA, Hiroyuki MORISAKA, Kazuto YOSHIMI
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Publication number: 20240124496Abstract: The invention provides a method for producing radiolabeled tyrosine derivatives with good purity and stability, by a safe method suitable for industrial production of pharmaceuticals. The invention relates to a method for producing Compound (5) and Radiolabeled Compound (6) as follows: wherein each symbol is as defined in the description.Type: ApplicationFiled: March 24, 2022Publication date: April 18, 2024Applicant: OSAKA UNIVERSITYInventors: Yoshifumi SHIRAKAMI, Kazuko KANEDA, Yuichiro KADONAGA, Tadashi WATABE, Atsushi TOYOSHIMA, Koichi FUKASE, Atsushi SHINOHARA, Toshio YAMANAKA, Yutaka KONDOH
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Publication number: 20240127956Abstract: Provided herein is a method for providing information about virus infection and/or virus infection disease in a subject, comprising: making a determination on the detection and/or stage classification of virus infection and/or virus infection disease in the subject using an indicator associated with a D-amino acid in the subject; and providing information about virus infection and/or virus infection disease in the subject based on the results of the determination.Type: ApplicationFiled: October 17, 2023Publication date: April 18, 2024Applicants: Osaka University, National Institutes of Biomedical Innovation, Health and Nutrition, Kagami Inc.Inventors: Yoshitaka ISAKA, Tomonori KIMURA, Shihoko KIMURA, Masashi MITA
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Patent number: 11959103Abstract: Provided is a method for inducing pluripotent stem cells to differentiate into somatic cells in a culture medium containing a heparin binding growth factor, the method comprising bringing cells into contact with a conjugate of a laminin E8 fragment and a growth factor binding domain-containing fragment of a heparan sulfate proteoglycan. According to the present invention, pluripotent stem cells can be induced to differentiate into any desired somatic cells in a highly efficient manner.Type: GrantFiled: November 9, 2017Date of Patent: April 16, 2024Assignees: OSAKA UNIVERSITY, KYOTO UNIVERSITYInventors: Kiyotoshi Sekiguchi, Fumi Ebisu, Hidetoshi Sakurai, Mingming Zhao, Megumu Saito
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Publication number: 20240117381Abstract: A CRISPR-Cas3 system was successfully established in a eukaryotic cell.Type: ApplicationFiled: September 14, 2023Publication date: April 11, 2024Applicant: OSAKA UNIVERSITYInventors: Tomoji MASHIMO, Junji TAKEDA, Hiroyuki MORISAKA, Kazuto YOSHIMI
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Publication number: 20240120817Abstract: A permanent magnet-type rotary electric machine includes a stator, a first rotor, and a second rotor. The stator includes a stator core, a plurality of stator teeth, a plurality of stator slots, a plurality of stator magnets, and a stator coil. The first rotor is disposed inside the stator core relative to the plurality of stator magnets. The second rotor is disposed inside the stator core relative to a plurality of first pole pieces. The second rotor includes a plurality of second pole pieces. A proportion of the number of the plurality of stator slots to the number of poles of the plurality of second pole pieces of the second rotor is greater than 1.25 and less than 1.5, or greater than 1.5 and less than 3.0.Type: ApplicationFiled: December 23, 2020Publication date: April 11, 2024Applicants: Mitsubishi Electric Corporation, OSAKA UNIVERSITYInventors: Haruyuki KOMETANI, Ryoji MIYATAKE, Takuro YAMADA, Kenji TANAKA, Katsuhiro HIRATA, Noboru NIGUCHI, Kazuaki TAKAHARA, Hironori SUZUKI, Takuya ITO
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Publication number: 20240117313Abstract: A method for producing a three-dimensional tissue construct comprising mature adipocytes, comprising incubating cells comprising at least fat-derived stein cells in the presence of one or more fatty acids selected from the group consisting of erucic acid, elaidic acid, oleic acid, palmitoleic acid, myristoleic acid, phytanic acid, and pristanic acid.Type: ApplicationFiled: February 15, 2022Publication date: April 11, 2024Applicants: TOPPAN INC., OSAKA UNIVERSITY, Kyoto Prefectural Public University CorporationInventors: Shiro KITANO, Michiya MATSUSAKI, Fiona LOUIS, Yoshihiro SOWA
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Patent number: 11951125Abstract: One drug (solid preparation) 100 of the present invention is a drug for a disease of kidney that contains a silicon fine particle, an aggregate of the silicon fine particles, or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of the kidney disease.Type: GrantFiled: April 21, 2021Date of Patent: April 9, 2024Assignee: OSAKA UNIVERSITYInventors: Hikaru Kobayashi, Yuki Kobayashi, Ryoichi Imamura, Norio Nonomura
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Patent number: 11950946Abstract: A technique for automating the identifying of a measurement point in cephalometric image analysis is provided. An automatic measurement point recognition method includes a step of detecting, from a cephalometric image 14 acquired from a subject, a plurality of peripheral partial regions 31, 32, 33, 34 for recognizing a target feature point, a step of estimating a candidate position of the feature point in each of the peripheral partial regions 31, 32, 33, 34 by the application of a regression CNN model 10, and a step of determining the position of the feature point in the cephalometric image 14 based on the distribution of the candidate positions estimated. In the step of detecting, for example, the peripheral partial region 32, a classification CNN model 13 trained with a control image 52 is applied.Type: GrantFiled: September 24, 2019Date of Patent: April 9, 2024Assignee: OSAKA UNIVERSITYInventors: Chihiro Tanikawa, Chonho Lee