Patents Assigned to OSHADI DRUG ADMINISTRATION LTD.
  • Methods and compositions for oral administration of protein and peptide therapeutic agents
    Patent number: 9949924
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
    Type: Grant
    Filed: December 9, 2014
    Date of Patent: April 24, 2018
    Assignee: Oshadi Drug Administration Ltd.
    Inventors: Alexander Vol, Orna Gribova
  • Matrix carrier compositions, methods and uses
    Patent number: 9504648
    Abstract: Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 29, 2016
    Assignee: Oshadi Drug Administration Ltd.
    Inventors: Alexander Vol, Orna Gribova
  • Matrix carrier compositions, methods and uses
    Patent number: 9060932
    Abstract: Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
    Type: Grant
    Filed: July 8, 2010
    Date of Patent: June 23, 2015
    Assignee: Oshadi Drug Administration Ltd.
    Inventors: Alexander Vol, Orna Gribova
  • Methods and compositions for oral administration of protein and peptide therapeutic agents
    Patent number: 8936786
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: January 20, 2015
    Assignee: Oshadi Drug Administration Ltd.
    Inventors: Alexander Vol, Orna Gribova
  • MATRIX CARRIER COMPOSITIONS, METHODS AND USES
    Publication number: 20120100216
    Abstract: Provided is a matrix carrier composition for use in pharmaceutical delivery system, the composition comprising an intermolecular association of at least a first solid phase comprising nanoparticles having hydrophobic surface, wherein the size of the nanoparticles is in the range of about 5-1000 nm, a second solid phase, comprising a biopolymer having hydrophilic and hydrophobic parts, and a continuous phase comprising oil associated with the first and said second solid phases.
    Type: Application
    Filed: July 8, 2010
    Publication date: April 26, 2012
    Applicant: OSHADI DRUG ADMINISTRATION LTD.
    Inventors: Alexander Vol, Orna Gribova
  • METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF PROTEIN AND PEPTIDE THERAPEUTIC AGENTS
    Publication number: 20100297245
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and a biologically active protein or peptide suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of a therapeutic protein or peptide.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 25, 2010
    Applicant: OSHADI DRUG ADMINISTRATION LTD.
    Inventors: Alexander Vol, Orna Gribova
  • METHODS AND COMPOSITIONS FOR ORAL ADMINISTRATION OF INSULIN
    Publication number: 20100278922
    Abstract: The present invention provides a pharmaceutical composition formulated for oral delivery of insulin, comprising a particulate non-covalently associated mixture of pharmacologically inert silica nanoparticles having a hydrophobic surface, a polysaccharide, and insulin suspended in an oil. The present invention further provides methods of manufacturing same and therapeutic methods utilizing same for oral delivery of insulin.
    Type: Application
    Filed: January 8, 2009
    Publication date: November 4, 2010
    Applicant: OSHADI DRUG ADMINISTRATION LTD.
    Inventors: Alexander Vol, Orna Gribova