Patents Assigned to Owlstone Inc.
  • Patent number: 11543385
    Abstract: An ion mobility filter is disclosed. The present invention relates to but not exclusively a field asymmetric ion spectrometry filter. For example, we describe an ion filter for filtering ions in a gas sample. The ion filter is comprised of a plurality of electrodes, a first ion channel, and a second ion channel. The first ion channel filters ions from a target chemical in the gas sample, defines a gap between a first pair of electrodes in the plurality of electrodes, and has a first ion channel gap width. The second ion channel filters ions from the target chemical in the gas sample, defines a gap between a second pair of electrodes in the plurality of electrodes, and has a second ion channel gap width. The first ion channel gap width is greater than the second ion channel gap width.
    Type: Grant
    Filed: October 5, 2018
    Date of Patent: January 3, 2023
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Daniel Melhirst, Jonathan Pearson, Max Allsworth
  • Patent number: 11530964
    Abstract: A sensor system comprising a housing having an inlet aperture through which fluid enters the housing and a conditioning material in the housing, the conditioning material being adapted to control levels of a substance within the housing. The sensor system comprises a sensor for analysing the fluid in the housing. The sensor system comprises circulation means which is configured to alternate circulation of fluid within the housing between a sensing fluid path in which the fluid is analysed by the sensor and a second fluid path in which the fluid flow is conditioned. A method for analysing fluid in a housing using a sensor is also provided.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: December 20, 2022
    Assignees: OWLSTONE MEDCIAL LIMITED, OWLSTONE INC.
    Inventors: Andrew H. Koehl, Max Allsworth
  • Patent number: 11513098
    Abstract: We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor.
    Type: Grant
    Filed: November 29, 2018
    Date of Patent: November 29, 2022
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Max Allsworth, Julian William Few, Isabel Marquez Sillero, Jonathan Pearson
  • Patent number: 11469742
    Abstract: The waveform generator (10) comprises a switch (13). The waveform generator (10) comprises a transformer (15) having a primary side circuit and a secondary side circuit. The primary side circuit has a first terminal arranged to be conductively coupled to a DC voltage source, and a second terminal conductively coupled to the switch (13). The waveform generator (10) further comprises a controller (11) arranged to supply a drive signal to the switch for switching the switch between on and off states. The controller (11) is arranged to adjust the frequency of the drive signal so as to control at least one of the peak voltage and the duty cycle of a waveform generated by the waveform generator (10). The frequency of the drive signal may be adjusted as the voltage level of the DC voltage source remains constant. The frequency of the drive signal may be adjusted in response to a change in the voltage level of the DC voltage source.
    Type: Grant
    Filed: October 18, 2019
    Date of Patent: October 11, 2022
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventor: Jonathan Pearson
  • Publication number: 20220221425
    Abstract: The present disclosure relates to sensor systems and methods for analysing fluid samples. The sensor system comprises a housing (220) having an inlet for a fluid sample to enter the housing, an outlet for the fluid sample to exit the housing, and a fluid sample path within the housing for the fluid sample to flow between the inlet and the outlet. The sensor system also comprises an ionizer (210) which is external to the housing and which is for ionizing the fluid sample at a first location on the fluid sample path to generate sample ions, an ion mobility filter (212) which is at least partially located within the housing and which is for filtering the generated sample ions at a second location on the fluid sample path, and a detector (214) which is external to the housing and which is for detecting the sample ions which pass through the ion mobility filter at a third location on the fluid sample path.
    Type: Application
    Filed: May 29, 2020
    Publication date: July 14, 2022
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventor: Max Allsworth
  • Publication number: 20220163482
    Abstract: The present techniques relate to methods of manufacturing MEMS gas sensors, for example, an ion mobility filter which may be used as a field asymmetric ion mobility spectrometry filter. The method comprises a step of providing a support with an aperture (S300, S302) and forming electrical connections (S304) in the support. The method also comprises steps of attaching an electrode layer to the support (S306) so that the electrode layer covers the aperture and forming a plurality of ion mobility electrodes (S308) by mechanically dicing through the electrode layer. Each adjacent pair of electrodes defines an ion channel between them and each electrode is separate from the adjacent electrode(s).
    Type: Application
    Filed: March 20, 2020
    Publication date: May 26, 2022
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventor: Jonathan Pearson
  • Patent number: 11333630
    Abstract: A waveform generator configured to generate two waveforms of opposite polarity so as to provide a voltage gain across a load. The waveform generator has a primary side circuit comprising a first inductor. The waveform generator has a secondary side circuit comprising a second inductor, a first output region conductively coupled to the load, and a second output region conductively coupled to the load. The second inductor is inductively coupled to the first inductor. The first inductor is conductively coupled to the first output region so as to supply a first of the two waveforms to the load. The second inductor is conductively coupled to the second output region so as to supply a second of the two waveforms to the load. A system incorporating the waveform generator and a method of driving the waveform generator are also provided.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: May 17, 2022
    Assignees: OWLSTONE MEDCIAL LIMITED, OWLSTONE INC.
    Inventors: Jonathan Pearson, Antoni Negri
  • Patent number: 11262331
    Abstract: An ion filter for filtering ions in a gas sample. The ion filter has a first ion channel for filtering ions from a target chemical in the gas sample. The ion filter has a second ion channel for filtering ions from the target chemical in the gas sample. The second ion channel is separated from the first ion channel. A temperature control region is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels. A method of filtering ions from a target chemical in a gas sample is also provided.
    Type: Grant
    Filed: September 10, 2018
    Date of Patent: March 1, 2022
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Daniel Melhirst, Jonathan Pearson, Max Allsworth
  • Publication number: 20210409006
    Abstract: The waveform generator (10) comprises a switch (13). The waveform generator (10) comprises a transformer (15) having a primary side circuit and a secondary side circuit. The primary side circuit has a first terminal arranged to be conductively coupled to a DC voltage source, and a second terminal conductively coupled to the switch (13). The waveform generator (10) further comprises a controller (11) arranged to supply a drive signal to the switch for switching the switch between on and off states. The controller (11) is arranged to adjust the frequency of the drive signal so as to control at least one of the peak voltage and the duty cycle of a waveform generated by the waveform generator (10). The frequency of the drive signal may be adjusted as the voltage level of the DC voltage source remains constant. The frequency of the drive signal may be adjusted in response to a change in the voltage level of the DC voltage source.
    Type: Application
    Filed: October 18, 2019
    Publication date: December 30, 2021
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventor: Jonathan Pearson
  • Patent number: 11092568
    Abstract: A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.
    Type: Grant
    Filed: November 15, 2018
    Date of Patent: August 17, 2021
    Assignees: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Max Allsworth, Daniel Melhirst, Matthew Hart
  • Publication number: 20210055186
    Abstract: A sensor system comprising a housing having an inlet aperture through which fluid enters the housing and a conditioning material in the housing, the conditioning material being adapted to control levels of a substance within the housing. The sensor system comprises a sensor for analysing the fluid in the housing. The sensor system comprises circulation means which is configured to alternate circulation of fluid within the housing between a sensing fluid path in which the fluid is analysed by the sensor and a second fluid path in which the fluid flow is conditioned. A method for analysing fluid in a housing using a sensor is also provided.
    Type: Application
    Filed: August 7, 2018
    Publication date: February 25, 2021
    Applicants: OWLSTONE MEDCIAL LIMITED, OWLSTONE INC.
    Inventors: Andrew H. Koehl, Max Allsworth
  • Publication number: 20210025850
    Abstract: We describe a method and apparatus for detecting humidity using a Field Asymmetric Ion Mobility Spectrometry (FAIMS) system. The system may comprise an ionizer for generating ions within a gas sample, wherein each ion has an associated ion mobility; an ion filter for separating the ions by applying a compensation field and a dispersion field to the generated ions; a detector for detecting an output from the ion filter; and a processor.
    Type: Application
    Filed: November 29, 2018
    Publication date: January 28, 2021
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Max Allsworth, Julian William Few, Isabel Marguez Sillero, Jon Pearson
  • Publication number: 20210007627
    Abstract: Mobile device (110) is disclosed. The present techniques relate to a mobile device or portable electronic device, particularly a device including a breath sampling device. The mobile electronic device (110) comprises a collection device (112) for collecting and storing a gas sample. The collection device (112) is accessible to enable analysis of the gas stored in the collection device (112). The collection device (112) comprises a mouthpiece (118) into which a user exhales. The collection device (112) further comprises a plurality of sorbent tubes (114) to collect and store the breath sample(s). Each tube (114) has a one-way valve (116) to prevent captured breath escaping.
    Type: Application
    Filed: March 12, 2019
    Publication date: January 14, 2021
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Andrew H. Koehl, Max Allsworth
  • Publication number: 20200363373
    Abstract: A method of manufacture for a ion mobility filter is disclosed. The method of manufacturing an ion filter for a spectrometry system includes providing a sheet of conductive material and defining a plurality of ion filters on the sheet. The definition of the plurality of ion filters is achieved by forming an electrode layer for each ion filter on the sheet, where each electrode layer comprises at least one ion channel and an isolation channel surrounding the at least one ion channel. A support layer on each electrode layer is also formed. Each support layer comprises an aperture at least partially aligned with the at least one ion channel. The ion filter is then separated. The risk of contaminants entering the at least one ion channel when separating the ion filters is reduced by surrounding the at least one ion channel with the isolation channel.
    Type: Application
    Filed: November 15, 2018
    Publication date: November 19, 2020
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Max Allsworth, Daniel Melhirst, Matthew Hart
  • Publication number: 20200278319
    Abstract: An ion filter for filtering ions in a gas sample. The ion filter has a first ion channel for filtering ions from a target chemical in the gas sample. The ion filter has a second ion channel for filtering ions from the target chemical in the gas sample. The second ion channel is separated from the first ion channel. A temperature control region is in thermal contact with the first and second ion channels for controlling a difference in temperature between the first and second ion channels. A method of filtering ions from a target chemical in a gas sample is also provided.
    Type: Application
    Filed: September 10, 2018
    Publication date: September 3, 2020
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Daniel Melhirst, Jon Pearson, Max Allsworth
  • Publication number: 20200232945
    Abstract: An ion mobility filter is disclosed. The present invention relates to but not exclusively a field asymmetric ion spectrometry filter. For example, we describe an ion filter for filtering ions in a gas sample. The ion filter is comprised of a plurality of electrodes, a first ion channel, and a second ion channel. The first ion channel filters ions from a target chemical in the gas sample, defines a gap between a first pair of electrodes in the plurality of electrodes, and has a first ion channel gap width. The second ion channel filters ions from the target chemical in the gas sample, defines a gap between a second pair of electrodes in the plurality of electrodes, and has a second ion channel gap width. The first ion channel gap width is greater than the second ion channel gap width.
    Type: Application
    Filed: October 5, 2018
    Publication date: July 23, 2020
    Applicants: Owlstone Medical Limited, Owlstone Inc.
    Inventors: Daniel Melhirst, Jon Pearson, Max Allsworth
  • Publication number: 20200173962
    Abstract: A waveform generator configured to generate two waveforms of opposite polarity so as to provide a voltage gain across a load. The waveform generator has a primary side circuit comprising a first inductor. The waveform generator has a secondary side circuit comprising a second inductor, a first output region conductively coupled to the load, and a second output region conductively coupled to the load. The second inductor is inductively coupled to the first inductor. The first inductor is conductively coupled to the first output region so as to supply a first of the two waveforms to the load. The second inductor is conductively coupled to the second output region so as to supply a second of the two waveforms to the load. A system incorporating the waveform generator and a method of driving the waveform generator are also provided.
    Type: Application
    Filed: July 16, 2018
    Publication date: June 4, 2020
    Applicants: OWLSTONE MEDCIAL LIMITED, OWLSTONE INC.
    Inventors: Jonathan Pearson, Antoni Negri
  • Patent number: 8487240
    Abstract: A method and sensor for monitoring chemical species in a gas flow are described. An ionized sample of gas is passed through a flow channel, with a DC electric field applied transverse to the longitudinal axis of the channel. Any electric current produced by the ion flow is measured, with variations in the current being indicative of a change in composition of the gas flow. In certain embodiments, the DC field may be varied over time, to sweep the field voltage. The detected current against field voltage graph may be taken as a profile of a particular gas composition. Variations in the profile again are indicative of a change in gas composition.
    Type: Grant
    Filed: September 21, 2010
    Date of Patent: July 16, 2013
    Assignee: Owlstone Inc.
    Inventor: Andrew H. Koehl