Patents Assigned to Oxon Medica, Inc.
  • Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress
    Patent number: 6759430
    Abstract: The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysfunction. In particular, the present invention relates to chemical compounds of Formula (I) wherein: R1 may be the same of different and are independently selected from hydrogen, alkoyl, carboxy, hydroxy, amino, amido, cyano, nitro, thio, sulphonyl, sulphoxide alkyl groups comprising an NO-donor, provided that at least one R1 is a group comprising an NO-donor; R2 may be the same or different and are independently selected from alkyl groups; n is an integer 1, 2, or 3; or a salt thereof.
    Type: Grant
    Filed: July 25, 2002
    Date of Patent: July 6, 2004
    Assignee: OxoN Medica Inc.
    Inventors: Erik Emil Anggard, Abdullah Ibrahim Haj-Yehia
  • Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress
    Patent number: 6455542
    Abstract: The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysfunction. For example, the present invention relates to chemical compounds of the formula: wherein R1 may be the same or different and are independently selected from hydrogen, alkoyl, alkoxy, carboxy, hydroxy, amino, amido, cyano, nitro, thio, sulphonyl, sulphoxide alkyl groups and groups comprising an NO-donor, provided that at least one R1 is a group comprising an NO-donor; R2 may the same or different and are independently selected from alkyl groups; n is an integer 1, 2 or 3; or a salt thereof.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: September 24, 2002
    Assignee: Oxon Medica Inc.
    Inventors: Erik Emil Anggard, Abdullah Ibrahim Haj-Yehia
  • Piperidine and pyrrolidine derivatives comprising a nitric oxide donor for treating stress
    Patent number: 6448267
    Abstract: The present invention relates to chemical compounds comprising a nitric oxide (NO) donor and a superoxide ion (O2−) scavenger, their preparation and their use in the treatment of conditions associated with oxidative stress or endothelial dysfunction. For example, the present invention relates to chemical compounds of the formula: wherein R1 may be the same or different and are independently selected from hydrogen, alkoyl, alkoxy, carboxy, hydroxy, amino, amido, cyano, nitro, thio, sulphonyl, sulphoxide alkyl groups and groups comprising an NO-donor, provided that at least one R1 is a group comprising an NO-donor; R2 may the same or different and are independently selected from alkyl groups; n is an integer 1, 2 or 3; or a salt thereof.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: September 10, 2002
    Assignee: Oxon Medica, Inc.
    Inventors: Erik Emil Anggard, Abdullah Ibrahim Haj-Yehia