Abstract: The subject application provides for an emulsion comprising an amount of a perfluorocarbon liquid dispersed as particles within a continuous liquid phase, wherein the dispersed particles have a monomodal particle size distribution and uses thereof. The subject application also provides for a method of manufacturing a perfluorocarbon emulsion, a process for preparing a pharmaceutical product containing a PFC emulsion and a process for validating a batch of an emulsion for pharmaceutical use.
Type:
Application
Filed:
August 27, 2013
Publication date:
March 6, 2014
Applicant:
OXYGEN BIOTHERAPEUTICS, INC.
Inventors:
Richard Kiral, Deborah P. Thompson, Gary L. Clauson
Abstract: This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue.
Type:
Application
Filed:
May 3, 2013
Publication date:
October 31, 2013
Applicants:
Virginia Commonwealth University, Oxygen Biotherapeutics, Inc.
Inventors:
Kevin R. Ward, Robert Diegelmann, Bruce Spiess, Gary S Huvard, Gurbhagat S Sandhu, Gary Bowlin, Chris Stern
Abstract: The subject application provides a method of treating pruritus comprising administering to the skin of a subject afflicted with pruritus an amount of a perfluorocarbon effective to treat the pruritus. The subject application also provides a method of alleviating a symptom of psoriasis comprising administering to the skin of a subject afflicted with psoriasis an amount of a perfluorocarbon effective to alleviate the symptom of psoriasis. The subject application also provides a perfluorocarbon composition for use in treating a subject afflicted with pruritus or psoriasis. The subject application further provides a pharmaceutical composition comprising an amount of a perfluorocarbon for use in treating pruritus or psoriasis.
Abstract: This invention provides for methods of treating a subject suffering from central nervous system injury, including traumatic brain injury, comprising administering to the subject an amount of a perfluorocarbon. This invention also provides for use of a perfluorocarbon in the manufacture of a medicament for treating a subject suffering from central nervous system injury including traumatic brain injury. This invention further provides for a pharmaceutical composition comprising a perfluorocarbon for use in treating a subject suffering from central nervous system injury, including traumatic brain injury.
Type:
Grant
Filed:
July 17, 2009
Date of Patent:
March 26, 2013
Assignees:
Oxygen Biotherapeutics, Inc., Virginia Commonwealth University
Inventors:
M. Ross Bullock, Bruce Spiess, Deborah P. Thompson