Patents Assigned to PA Knowledge Limited
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Publication number: 20230366152Abstract: A method of barrier coating a porous substrate, the method comprising: coating a surface of the substrate with an intermediate layer, said intermediate layer filling pores at the surface of the substrate; and coating the intermediate layer with a non-polymer barrier layer.Type: ApplicationFiled: September 15, 2021Publication date: November 16, 2023Applicant: PA KNOWLEDGE LIMITEDInventors: Rodney Edward SMITH, Craig Harvey NELSON, William Frank TYLDESLEY, Stuart Michael Ruan JONES
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Patent number: 10605758Abstract: A method and device are provided for measuring a level of a clinically relevant analyte (such as glucose) in a fluid (such as blood). The device includes a flow path for conducting said fluid through the device; a detection chamber arranged on said flow path; and detector means arranged to detect analyte levels in the fluid in said chamber, wherein: said detection chamber contains a predetermined amount of an analyte such that that analyte mixes with fluid in the detection chamber to form, at the detector means, a calibration sample of the fluid at a time after the arrival of the fluid in said detection chamber, and said detector means is arranged to detect a first analyte level of an unadulterated sample of the fluid at a first time which is before the formation of said calibration sample and to detect a second analyte level of said calibration sample at a second time which is after the formation of said calibration sample.Type: GrantFiled: May 10, 2016Date of Patent: March 31, 2020Assignee: PA Knowledge LimitedInventors: Michael Noble, Craig Nelson, Mark Humphries, Carys Lloyd, David Edington, John Rippeth
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Patent number: 10222379Abstract: The present invention provides a flexible format for diagnostic tests that is applicable to measuring a wide range of properties of fluids, particularly physiological fluids, by creating a concentration gradient of an indicator in the sample under analysis and measuring a flux of the indicator through the sample which is used to determine a property of the sample. Aspects of the invention include a method of testing a property of a physiological fluid in a portable test device, a portable test device and a kit including a portable test device and a processor.Type: GrantFiled: September 10, 2013Date of Patent: March 5, 2019Assignee: PA KNOWLEDGE LIMITEDInventors: Michael Noble, Simon Kew, David Edington, John Rippeth, Mark Humphries
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Publication number: 20150219531Abstract: Disclosed is apparatus for distributing a solid, gel, powder or viscous test substance in an extraction fluid, the apparatus comprising a flow cell for holding the test substance and having an inlet and an outlet; an extraction chamber located between said inlet and outlet comprising a convergent nozzle; and a recirculating pump for driving extraction fluid: (i) into the flow cell via the inlet; (ii) through the extraction chamber; and (iii) back to the flow cell via the outlet, whereby a pressure differential is established across the extraction chamber such that the velocity of the extraction fluid is greater at the outlet than at the inlet; characterized in that the apparatus further comprises a tortuous path flow control valve (TPV) located at the outlet and configured to permit flow of extraction fluid and extracted test substance but to prevent or retard passage of said test substance through the outlet.Type: ApplicationFiled: July 30, 2013Publication date: August 6, 2015Applicants: PA KNOWLEDGE LIMITED, CAMBTEK LIMITEDInventors: Anthony Hawkins, Thomas Watt, Colin Turner, Jonathan Howells, Hugh Malkin, Graham Gutsell, Nicholas Hastings, Nicholas Mounteney
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Publication number: 20110183057Abstract: A foaming device for a drink including a housing defining an internal volume for housing secondary liquid and a source of foaming gas. A nozzle communicates between the internal volume and an exterior of the housing and a plug seals the nozzle so as to prevent communication between the internal volume and the exterior of the housing. By releasing the plug, the secondary liquid can be released into the drink such that the foaming gas forms bubbles of secondary liquid in the drink and proteins/constituents within one or both of the primary liquid and the secondary liquid denature so as to create a stable foam.Type: ApplicationFiled: March 19, 2009Publication date: July 28, 2011Applicant: PA KNOWLEDGE LIMITEDInventors: Stuart Michael Ruan Jones, Mark Robson Humphries, David Morrison Russell
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Publication number: 20100036319Abstract: An auto injector including: a housing; an outlet portion with a needle (110) moveable relative to the housing; a container (104) within the housing for containing medicament; and an actuatable deployment mechanism configured to deploy the outlet portion by moving the outlet portion relative to the housing and to eject medicament contained in the container through the outlet portion. The auto injector is configured to store a volume of fluid and includes a filling mechanism configured to expel the volume of fluid from the outlet portion and subsequently to draw medicament through the outlet portion and into the container. An adaptor (112) fits to the auto injector so as to cover the needle and includes a puncture member configured to puncture a vial, the puncture member providing fluid communication to the needle.Type: ApplicationFiled: January 28, 2008Publication date: February 11, 2010Applicant: PA KNOWLEDGE LIMITEDInventors: David Drake, Douglas Ivan Jennings, Stuart David Cooper, Timothy Donald Barrow-Williams, Joseph Peter Corrigan, Rosalind Trudy Lee, David Whitaker
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Publication number: 20090024057Abstract: A catheter for insertion into a blood vessel, the catheter having a sampling part arranged to capture a blood sample at a plurality of locations along a length of the blood vessel and an apparatus arranged to analyse blood taken from a plurality of locations along the length of the blood vessel and to provide a profile of concentration levels along the length of the blood vessel.Type: ApplicationFiled: May 25, 2006Publication date: January 22, 2009Applicant: PA KNOWLEDGE LIMITEDInventors: Richard Harley Grenville Owen, Stephen Blatcher, Stewart Maddison Fox, Martin Lawrence Hughes
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Patent number: 6853952Abstract: Methods of doing business and systems for implementing those methods which improve the effectiveness and success of the research and development of technology such as pharmaceuticals, biotechnology, agrochemicals, medical technology, and genomics. The methods include the application of value and cost modeling methodologies to provide a pharmaceutical, biotechnology or genomics research and development organization with information and data which will assist it in making choices and decisions about its prospective products and the manner of research and development thereof in order to realize the greatest economic gain from commercialization of the products.Type: GrantFiled: May 13, 2003Date of Patent: February 8, 2005Assignee: PA Knowledge LimitedInventor: Andrew Thomas Chadwick
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Publication number: 20040230397Abstract: Methods of doing business and systems for implementing those methods which improve the effectiveness and success of the research and development of technology such as pharmaceuticals, biotechnology, agrochemicals, medical technology, and genomics. The methods include the application of value and cost modeling methodologies to provide a pharmaceutical, biotechnology or genomics research and development organization with information and data which will assist it in making choices and decisions about its prospective products and the manner of research and development thereof in order to realize the greatest economic gain from commercialization of the products.Type: ApplicationFiled: May 13, 2003Publication date: November 18, 2004Applicant: PA Knowledge LimitedInventor: Andrew Thomas Chadwick
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Patent number: 6405727Abstract: A dosing device comprising a dispensing means for dispensing a dose material, and a dose actuation mechanism, in which the dose actuation mechanism comprises a readily deflectable member, and a cascade of at least two pivoted elements, movement of one causing movement of the other, wherein the deflectable member is moveable by the user, and its movement is transferred to the first of the cascade of pivoted elements, so as to actuate the dispensing means. A first biasing means communicates with one pivoted element so that as movement is transferred between the pivoted elements, energy stored in the first biasing means is released to increase the force associated with the movement. A dose actuating mechanism for use in a dosing inhaler is also provided.Type: GrantFiled: February 15, 2000Date of Patent: June 18, 2002Assignee: PA Knowledge LimitedInventors: Donald Bruce Atherton MacMichael, David John Hearne