Patents Assigned to PACYLEX PHARMACEUTICALS INC.
  • SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
    Publication number: 20230374603
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein.
    Type: Application
    Filed: March 24, 2023
    Publication date: November 23, 2023
    Applicant: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap, Erwan Beauchamp
  • Epigeneiic silencing of NMT2
    Patent number: 11788145
    Abstract: The finding that multiple cancers lack one of two NMTs, while stromal and normal tissues do not, enables the treatment of NMT2-deficient cancer cells with an NMT inhibitor. It is shown herein that NMT2 expression is reduced or eliminated in certain cancers, and in one example lymphomas, via an epigenetic mechanism(s). Reduction or elimination of NMT2 expression renders the cancer sensitive inhibitors of NMT.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: October 17, 2023
    Assignee: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Erwan Beauchamp
  • SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
    Publication number: 20220023294
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein. In one aspect of the present invention, there is provided a method of treating a subject having a cancer deficient in NMT2, comprising: administering to said subject an NMT inhibitor.
    Type: Application
    Filed: October 1, 2021
    Publication date: January 27, 2022
    Applicant: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Erwan Beauchamp, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap
  • Synthetic lethality and the treatment of cancer
    Patent number: 11135218
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein. In one aspect of the present invention, there is provided a method of treating a subject having a cancer deficient in NMT2, comprising: administering to said subject an NMT inhibitor.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: October 5, 2021
    Assignee: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Erwan Beauchamp, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap
  • SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
    Publication number: 20190010555
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein.
    Type: Application
    Filed: April 2, 2018
    Publication date: January 10, 2019
    Applicant: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap, Erwan Beauchamp
  • SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
    Publication number: 20190000838
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein. In one aspect of the present invention, there is provided a method of treating a subject having a cancer deficient in NMT2, comprising: administering to said subject an NMT inhibitor.
    Type: Application
    Filed: July 2, 2018
    Publication date: January 3, 2019
    Applicant: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Erwan Beauchamp, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap
  • SYNTHETIC LETHALITY AND THE TREATMENT OF CANCER
    Publication number: 20140227284
    Abstract: Described herein are compounds, compositions and methods for treatment of cancer. Also described are methods and uses for identifying subject with cancer that are suitable for treatment with the compounds, composition and methods are described herein. In one aspect of the present invention, there is provided a method of treating a subject having a cancer deficient in NMT2, comprising: administering to said subject an NMT inhibitor.
    Type: Application
    Filed: July 23, 2012
    Publication date: August 14, 2014
    Applicant: PACYLEX PHARMACEUTICALS INC.
    Inventors: Luc G. Berthiaume, Erwan Beauchamp, Conganige Maneka Anne Perinpanayagam, Chuiyee Yap