Abstract: Disclosed is a self-wetting porous membrane comprising an aromatic hydrophobic polymer such as polysulfone and a wetting agent comprising a copolymer of formula A-B or A-B-A, wherein A is a hydrophilic segment comprising a polymerized monomer of the formula (I): CH2?C(R1)(R2), wherein R1 and R2 are as described herein, and B is polyethersulfone, wherein segments B and A are linked through an oxygen atom. Also disclosed is a method of preparing a self-wetting membrane comprising casting a solution containing an aromatic hydrophobic polymer and the wetting agent, followed by subjecting the cast solution to phase inversion. The self-wetting porous membrane finds use in hemodialysis, microfiltration, and ultrafiltration.

Abstract: Drain valves with rotatable angled outlets that can be rotated without allowing flow or stopping flow through the valve, containers including the valves, and methods of using the valves, are disclosed.

Abstract: Disclosed are polymers suitable for hydrophilically modifying the surface of porous fluoropolymer supports, for example, a copolymer of the formula: Also disclosed are a method of preparing the polymers, a method of hydrophilically modifying porous fluoropolymer supports, hydrophilic fluoropolymer porous membranes prepared from the polymers, and a method of filtering fluids through the porous membranes.

Abstract: The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Abstract: A diafiltration system comprises a fluid treatment assembly comprising two or more fluid treatment modules, the fluid treatment assembly comprising a feed inlet, a permeate outlet, and a retentate outlet; each module comprising a cross flow treatment assembly including an ultrafiltration membrane and having a feed side and a permeate side, and a diafiltration fluid distribution plate comprising a diafiltration fluid feed inlet and a common feed permeate/diafiltration fluid permeate outlet port; two or more diafiltration fluid conduits, each conduit in fluid communication with a respective single diafiltration fluid feed inlet; and, a diafiltration fluid pump comprising at least a first multiple channel pump head having at least two channels including separate channels for separate conduits in fluid communication with respective single diafiltration fluid feed inlets, wherein the pump provides simultaneously controlled diafiltration fluid flow rates through each of the conduits to the respective diafiltration

Abstract: Disclosed is an SPR sensor which includes a thermally controlled biosensor. Additionally, the current disclosure describes SPR techniques which include the step of heating the SPR sensor to temperatures greater than ambient temperature.

Abstract: Disclosed are fluoropolymers with low CWST values and porous membranes made from the fluoropolymers. The fluoropolymer is made up of polymerized monomeric units of the formula A-X—CH2—B, wherein A is C6F13—(CH2)2, X is O or S, and B is vinylphenyl, and the fluoropolymer has a weight average molecular weight (Mw) of at least 100 Kd and/or a glass transition temperature of at least 33° C. copolymer. The porous membranes are suitable for degassing a variety of fluids.

Abstract: Disclosed is a method for preparing dispersion gradients and an SPR injection method for determining full kinetics and affinity analysis in the presence of a competitor molecule. The SPR injection provides a dispersion gradient of two or more samples to a SPR flow cell and detector.

Abstract: Filter assemblies comprising filter cartridges having a first coupling member including at least one lug having an outer diameter, and a support comprising a second coupling member having at least one channel for receiving the lug, the channel having corresponding channel walls, a terminal section including a closed end and a horizontal axis, and an angled section having an open end, the terminal section including a lug retaining section having a cross-sectional area less than the outer diameter of the lug, methods of coupling the cartridges to the supports, and methods of using the filter assemblies, are disclosed.

Abstract: A dual bag filter is provided where a replaceable filter element resides in and is sealed to a filter housing. The filter element has a mounting ring, an inner bag, and an outer bag. The inner bag is sized such that it has more surface area than the outer bag and is constrained by the outer bag. The inner bag is formed from a filter medium of different densities such that when the inner bag is crumpled, fluid flow is not restricted. A perforated central core keeps opposing sides of the inner bag from making contact.

Abstract: A dual bag filter is provided where a replaceable filter element resides in and is sealed to a filter housing. The filter element has a mounting ring, an inner bag, and an outer bag. The inner bag is sized such that it has more surface area than the outer bag and is constrained by the outer bag. The inner bag is formed from a filter medium of different densities such that when the inner bag is crumpled, fluid flow is not restricted.

Abstract: Dispersion injection methods for determining biomolecular interaction parameters in label-free biosensing systems are provided. The methods generally relate to the use of a single analyte injection that generates a smoothly-varying concentration gradient via dispersion en route to a sensing region possessing an immobilized binding partner. The present method incorporates the use of an internal standard which provides a reference as to the dispersion conditions present which can then be used to calculate an effective diffusion coefficient for the analyte of interest based on a universal calibration function. The effective diffusion coefficient can then be incorporated into the appropriate dispersion model to provide a calibrated dispersion model. The calibrated dispersion model can then be incorporated into the desired interaction model to provide a reliable representation of the analyte concentration at the sensing region at any time during the injection.

Abstract: Disclosed is a fluorinated polymer of the formula: R—S—P, wherein R is a fluorocarbyl group, S is sulfur, and P is: (i) polyglycerol; (ii) poly(allyl glycidyl ether); (iii) a copolymer of glycidol and allyl glycidyl ether, the copolymer having one or more allyl groups; or (iv) poly(allyl glycidyl ether) or copolymer of glycidol and allyl glycidyl ether, wherein one more of the allyl groups have been replaced with a functional group as described herein. Also disclosed is a method of preparing the fluorinated polymer. The fluorinated polymer finds use in improving the hydrophilicity of porous hydrophobic membranes such as PTFE and PVDF.

Abstract: A multiwell assembly includes a microplate and a cover. The microplate includes a set of wells. Each well defines an opening. The cover includes a body and a shutter. The body of the cover is disposed over the microplate. The shutter is mounted to the body such that the shutter is movable over a range of travel between a first position, in which the shutter occludes the openings of the set of wells, and a second position, in which the shutter is in offset relationship to the openings of the set of wells to permit access to the set of wells through the respective openings.

Abstract: Disclosed are fluoropolymers with low CWST values and porous membranes made from the fluoropolymers. The fluoropolymer is made up of polymerized monomeric units of the formula A-X—CH2—B, wherein A is C6F13—(CH2)2, X is O or S, and B is vinylphenyl, and the fluoropolymer has a weight average molecular weight (Mw) of at least 100 Kd and/or a glass transition temperature of at least 33° C. copolymer. The porous membranes are suitable for degassing a variety of fluids.

Abstract: A multiwell assembly includes a microplate and a cover. The microplate includes a set of wells. Each well defines an opening. The cover includes a body and a shutter. The body of the cover is disposed over the microplate. The shutter is mounted to the body such that the shutter is movable over a range of travel between a first position, in which the shutter occludes the openings of the set of wells, and a second position, in which the shutter is in offset relationship to the openings of the set of wells to permit access to the set of wells through the respective openings.

Abstract: Fuel tank inerting prefilter assemblies, fuel tank inerting prefilter devices, and methods for treating fluids, particularly process fluids used in fuel inerting tank systems, are disclosed.

Abstract: Disclosed are a copolymer, porous membranes made from the copolymer, and a method of treating fluids to remove metal ions using the porous membranes, for example, from fluids originating in the microelectronics industry, wherein the copolymer includes monomeric units I and II, wherein monomeric unit I is of the formula A-X—CH2—B, wherein A is Rf—(CH2)n, Rf is a perfluoro alkyl group of the formula CF3—(CF2)x—, wherein x is 3-12, n is 1-6, X is O or S, and B is vinylphenyl, and monomeric unit II is vinylpyridine.

Abstract: Disclosed are a copolymer, porous membranes made from the copolymer, and a method of treating fluids using the porous membranes to remove metal ions, for example, from fluids originating in the microelectronics industry, wherein the copolymer includes polymerized monomeric units I and II, wherein monomeric unit I is of the formula A-X—CH2—B, wherein A is Rf—(CH2)n, Rf is a perfluoro alkyl group of the formula CF3—(CF2)x—, wherein x is 3-12, n is 1-6, X is O or S, and B is vinylphenyl, the monomeric unit II is haloalkyl styrene, and optionally wherein the halo group of haloalkyl is replaced with an optional substituent, for example, ethylenediamine tetra acetic acid, iminodiacetic acid, or iminodisuccinic acid.

Abstract: Fluid impellers for biocontainers, and bioprocessing units including the impellers and biocontainers, and methods of using the impellers, are disclosed.