Patents Assigned to PARADIGM BIOPHARMACEUTICALS LTD
  • Treatment of pain with polysulfated polysaccharides
    Patent number: 11752169
    Abstract: The present disclosure relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions. In particular, the disclosure relates to use of polysulfated polysaccharides and compositions thereof for the treatment of pain or pain conditions mediated by mature Nerve Growth Factor (NGF) or its precursor pro-Nerve Growth Factor (pro-NGF).
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: September 12, 2023
    Assignee: PARADIGM BIOPHARMACEUTICALS LTD.
    Inventors: Paul Rennie, Ravi Krishnan
  • Treatment of post-operative joint pain with polysulfated polysaccharides
    Patent number: 11701382
    Abstract: The present invention relates to medical use of polysulfated polysaccharides and compositions thereof in the treatment of post-operative joint pain in a mammal. In particular, the invention relates to the use of the polysulfated polysaccharide, pentosan polysulfate, and compositions thereof in the treatment of aseptic persistent pain after joint arthroplasty in a mammal.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: July 18, 2023
    Assignee: PARADIGM BIOPHARMACEUTICALS LTD
    Inventors: Paul Rennie, Ravi Krishnan
  • TREATMENT OF ACUTE RESPIRATORY DISEASE SYNDROME (ARDS) WITH POLYSULFATED POLYSACCHARIDES
    Publication number: 20230136817
    Abstract: Methods for the treatment of Acute Respiratory Distress Syndrome (ARDS), particularly ARDS caused by viral infections such as influenza and SARS-CoV-2, comprising the administration of pentosan polysulfate (PPS) are provided. Some provided methods comprise the administration of sodium pentosan polysulfate. Prophylactic methods comprising the administration (for example, intra-nasally) of sodium pentosan polysulfate to inactivate a vims which is causative of ARDS are also provided.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 4, 2023
    Applicant: Paradigm Biopharmaceuticals Ltd.
    Inventors: Paul Rennie, Ravi KRISHNAN
  • Treatment of bone marrow pathologies with polysufated polysaccharides
    Patent number: 11617763
    Abstract: The present invention relates to the medical use of polysulfated polysaccharides and compositions thereof for the treatment of disease or disorders associated with bone marrow pathologies in the musculoskeletal system of a mammal. In particular, the invention relates to use of polysulfated polysaccharides, such as pentosan polysulfate, in treatment of bone marrow edema lesions or spinal Modic Endplate Changes as assessed by magnetic resonance imaging (MRI).
    Type: Grant
    Filed: August 6, 2018
    Date of Patent: April 4, 2023
    Assignee: PARADIGM BIOPHARMACEUTICALS LTD
    Inventors: Ravi Krishnan, Paul Rennie