Abstract: The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.

Abstract: The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.

Abstract: The present invention relates to a process for biocatalytic amidation of non-protected amino acids comprising the step of contacting a non-protected amino acid with an ammonia source in the presence of an organic solvent and an enzyme.

Abstract: The present invention relates to a method for producing chiral ?-nitro alcohol compounds. The invention relates in particular to an (R)-selective cupin-nitroaldolase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding ?-nitro alcohol compound in the presence of a nitroalkane compound and a cupin-nitroaldolase.

Abstract: The invention relates to a process for the manufacture of an alkylfluoroacrylate starting from alkylfluoroacetate and an oxalic acid ester, wherein an alkane liquid under the reaction conditions is applied as the solvent in one of the reaction steps.

Abstract: The invention pertains to a process for preparing a compound of formula (1) wherein R1 is independently chosen from C1-C6 alkyl, cycloalkyl, aralkyl and aryl, and R2, R3 and R4 are independently chosen from hydrogen and C1-C6 alkyl, cycloalkyl, aralkyl and aryl; which process comprises the steps of: a) contacting a compound of formula (2) wherein R1 and R2 are as above and M+ is a monovalent metal ion, with a compound of formula (3) wherein R3 and R4 are as above, to form a compound of formula (4) and b) followed by contacting the compound of formula (4) with an acid to give a compound of formula (1), wherein step (a) and/or step (b) are conducted in continuous mode.

Abstract: A process for preparing 1-cyclopropyl-naphthalene derivatives of Formula (1) wherein R1-R7 are independently hydrogen, alkyl, alkoxy, cycloalkyl or aryl comprising the steps of a) contacting an acid salt of a 1-naphthyl-2-aminoethylketone with a base and a first solvent to obtain a solution wherein the molar ratio of base to 1-naphthyl-2-aminoethylketone acid salt is at least 0.7, b) addition of hydrazine to obtain a 3-(1-naphthyl)-1H-pyrazoline, c) optionally adding a second solvent and/or at least partially removing the first solvent, and d) heating the reaction mixture to a temperature above 190° C. to obtain the compound of Formula (1).

Abstract: The present invention relates to a method for producing chiral ?-nitro alcohol compounds. The invention relates in particular to an (R)-selective cupin-nitroaldolase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding ?-nitro alcohol compound in the presence of a nitroalkane compound and a cupin-nitroaldolase.

Abstract: The invention pertains to a process for preparing a compound of formula (1) wherein R1 is independently chosen from C1-C6 alkyl, cycloalkyl, aralkyl and aryl, and R2, R3 and R4 are independently chosen from hydrogen and C1-C6 alkyl, cycloalkyl, aralkyl and aryl; which process comprises the steps of: a) contacting a compound of formula (2) wherein R1 and R2 are as above and M+ is a monovalent metal ion, with a compound of formula (3) wherein R3 and R4 are as above, to form a compound of formula (4) and b) followed by contacting the compound of formula (4) with an acid to give a compound of formula (1), wherein step (a) and/or step (b) are conducted in continuous mode.

Abstract: The present invention relates to a method for producing chiral ?-nitro alcohol compounds. The invention relates in particular to an (R)-selective cupin-nitroaldolase, which enantioselectively can catalyze the Henry reaction, wherein an aldehyde or ketone compound is converted to the corresponding ?-nitro alcohol compound in the presence of a nitroalkane compound and a cupin-nitroaldolase.

Abstract: The present invention relates to an apparatus comprising a) an unbaffled reactor or microreactor having a channel defined by a pathway, and b) an oscillating flow device, wherein the channel pathway comprises a plurality of directional changes. The reactor channel has a hydrolic diameter from 0.1 mm to 10 mm. A method of making said apparatus and the use of said apparatus to carry out a process on a suspension is also disclosed.

Abstract: The invention relates to a process for drying a moist polymeric material to obtain a dried polymeric material, comprising the steps of: mixing the moist polymeric material with an aqueous solution of a carbohydrate to afford a mixture of the moist polymeric material with the carbohydrate; and heating and/or filtering the mixture of the moist polymeric material with the carbohydrate to remove an amount of volatiles to obtain a predried polymeric material having a volatiles content VCpre-dried (pre-drying step); fluidizing the pre-dried material in a fluidized bed in order to further remove an amount of volatiles to obtain the dried polymeric material having a volatiles content VCdried (fluidized bed drying step); and withdrawing and collecting the dried polymeric material from the fluidized bed; wherein VCpre-dried is higher than VCdried and the moist polymeric material comprises at least a polymeric material, said polymeric material comprises fluorine permanently bonded to said polymeric material.