Abstract: An interlocking skylight and roof panel assembly includes a skylight unit having a glazing unit with a plurality of sides and a frame assembly secured around the glazing unit. The frame assembly includes a channel shaped first frame member having a first leg, a spaced second leg and a third leg interconnecting the first and second legs. Each of the first and second legs includes an inwardly turned flange. A roof panel includes a first skin, a spaced second skin and a panel of material secured therebetween. Defined along one edge of the roof panel are a pair of spaced channels. The inwardly turned flanges of the skylight unit frame assembly can be interlocked into the edge channels of the roof panel.