Patents Assigned to PBL Biomedical Laboratories
  • Patent number: 6514753
    Abstract: Modified proteins, modified interferons &agr;'s and &bgr;'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-&agr;-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-&agr;-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-&agr;-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: February 4, 2003
    Assignee: PBL Biomedical Laboratories, Inc.
    Inventor: Sidney Pestka
  • Patent number: 6300474
    Abstract: A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: October 9, 2001
    Assignee: PBL Biomedical Laboratories
    Inventor: Sidney Pestka
  • Patent number: 6299870
    Abstract: A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
    Type: Grant
    Filed: February 8, 1999
    Date of Patent: October 9, 2001
    Assignee: PBL Biomedical Laboratories
    Inventor: Sidney Pestka
  • Patent number: 6225455
    Abstract: Modified proteins, modified interferons &agr;'s and &bgr;'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-&agr;-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-&agr;-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-&agr;-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.
    Type: Grant
    Filed: January 19, 1995
    Date of Patent: May 1, 2001
    Assignee: PBL Biomedical Laboratories
    Inventor: Sidney Pestka
  • Patent number: 6001589
    Abstract: A new class of polypeptides is disclosed, along with a method for identifying and producing such polypeptides, having the characteristic of being unique to diseased states, particularly tumors and blood-borne malignancies. These new polypeptides are active and will be useful for therapeutic purposes.
    Type: Grant
    Filed: June 9, 1995
    Date of Patent: December 14, 1999
    Assignee: PBL Biomedical Laboratories, Inc.
    Inventor: Sidney Pestka
  • Patent number: 5986061
    Abstract: Modified proteins, modified interferons .alpha.'s and .beta.'s, phosphorylated modified proteins and DNA sequences encoding the above, applications and uses thereof. Modified phosphorylated Hu-IFN-.alpha.-like proteins are provided which carry an identifiable label such as a radio-label. Corresponding phosphorylatable Hu-IFN-.alpha.-like proteins which contain a putative phosphorylation site. DNA sequences which encode a Hu-IFN-.alpha.-like protein and contain a sequence encoding a putative phosphorylatable site. Appropriate expression vectors are used to transform compatible host cells of various microorganisms, such as E. coli. Numerous uses for the phosphorylated proteins are disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 16, 1999
    Assignee: PBL Biomedical Laboratories
    Inventor: Sidney Pestka