Abstract: Generally, the inventive technology relates to novel strategies for disease control in animal systems. Specifically, the inventive technology relates to novel methods, systems and compositions for the biocontrol of pathogens in aquatic systems. Specifically, the invention may comprise novel techniques, systems, and methods for the biocontrol of disease-transmitting pathogens affecting shrimp in aquaculture systems.
Type:
Grant
Filed:
August 7, 2018
Date of Patent:
April 2, 2024
Assignee:
Pebble Labs Inc.
Inventors:
Richard Sayre, Tatiana Vinogradova-Shah, Elena Sineva
Abstract: The current invention includes systems, methods and compositions for the generation of sRNA molecules using select RNase III mutants. In one preferred embodiment, invention includes systems, methods and compositions for the generation of sRNA molecules using RNase III mutants to control a host pathogen through the production and diffusion of sRNA molecules that may initiate an RNAi pathway response directed to a host pathogen. Additional embodiments of the current invention include systems, methods and compositions for the DICER-independent generation of sRNA molecules using select RNase III mutants.
Type:
Grant
Filed:
April 1, 2019
Date of Patent:
October 31, 2023
Assignee:
Pebble Labs Inc.
Inventors:
Guohua Yin, Erick Scott Lebrun, Timothy S. Travers
Abstract: The inventive technology relates to novel paratransgenic strategies for the biocontrol of pathogens in animal systems using interfering RNA molecules expressed in genetically modified bacteria that may be configured to colonize a target host. In one preferred embodiment, the invention includes novel paratransgenic strategies for the biocontrol of pathogens in aquatic organisms raised in aquaculture environments.
Type:
Grant
Filed:
September 14, 2020
Date of Patent:
September 20, 2022
Assignee:
PEBBLE LABS INC.
Inventors:
Richard T. Sayre, Tatiana Vinogradova-Shah, Elena Sineva
Abstract: The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel paratransgenic system configured to deliver one or more inhibitory RNA molecules to pathogen/disease-transmitting organisms. In a preferred embodiment, the invention may include one or more genetically engineered symbiotic bacteria configured to persist throughout the life-cycle of a mosquito and deliver one or more interfering RNA molecules to pathogen/disease-transmitting mosquitoes.
Type:
Grant
Filed:
July 10, 2018
Date of Patent:
July 26, 2022
Assignees:
PEBBLE LABS INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
Inventors:
Richard Sayre, Jiannong Xu, Bradley R. Borlee, Konstantinos Lymperopoulos, Rebekah Kading, William Black, Kenneth Olson, Carol Blair
Abstract: The inventive technology relates to novel paratransgenic strategies for the control of pathogens. The inventive technology may specifically include a novel paratransgenic system configured to deliver one or more inhibitory RNA molecules to pathogen/disease-transmitting organisms. In a preferred embodiment, the invention may include one or more genetically engineered enteric bacteria configured to deliver one or more interfering RNA molecules to pathogen/disease-transmitting mosquitos.