Patents Assigned to Pepgen Corporation and University of Florida
  • Low-toxicity human interferon-alpha analogs
    Patent number: 6204022
    Abstract: The invention describes a method of reducing the cytotoxicity of interferon-alpha by making defined amino acid substitutions in the N-terminal portion of the polypeptide sequence. Also described are human interferon-alpha analogs with low cytotoxicity, and therapeutic applications of the low toxicity interferon-alpha analogs.
    Type: Grant
    Filed: October 20, 1997
    Date of Patent: March 20, 2001
    Assignee: Pepgen Corporation and University of Florida
    Inventors: Howard M. Johnson, Carol H. Pontzer, Prem S. Subramaniam, Lorelie H. Villarete, Jackeline Campos