Patents Assigned to Peptor Limited
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Patent number: 6841533Abstract: Novel peptides which are conformationally constrained backbone cyclized antagonists of IL-6, are disclosed. Methods for synthesizing the IL-6 antagonists are also disclosed. Furthermore, pharmaceutical compositions comprising IL-6 antagonists, and methods of using such compositions are disclosed.Type: GrantFiled: August 24, 2000Date of Patent: January 11, 2005Assignee: Peptor LimitedInventors: Vered Hornik, Eran Hadas
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Patent number: 6706862Abstract: Novel backbone-cyclized BPI peptide analogs and methods of making the same by the use of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N&agr;-functionalized amino acids constructed to include a spacer and a terminal functional group. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. A plurality of these N&agr;&ohgr;-functionalized amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis.Type: GrantFiled: April 20, 2000Date of Patent: March 16, 2004Assignee: Peptor LimitedInventor: Vered Hornik
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Patent number: 6407059Abstract: Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are N&agr;(&ohgr;-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N&agr;(&ohgr;-functionalized) amino acids are incorporated into a peptide sequence, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is specifically exemplified by backbone cyclized bradykinin antagonists having biological activity. Further embodiments of the invention are somatostatin analogs having one or two ring structures involving backbone cyclization.Type: GrantFiled: May 31, 2000Date of Patent: June 18, 2002Assignee: Peptor LimitedInventors: Chaim Gilon, Doron Eren, Irina Zeltser, Alon Seri-Levy, Gal Bitan, Dan Muller
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Patent number: 6355613Abstract: Novel peptides which are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions are disclosed.Type: GrantFiled: December 2, 1998Date of Patent: March 12, 2002Assignee: Peptor LimitedInventors: Vered Hornik, Gary Gellerman, Mich El M. Afargan
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Patent number: 6265375Abstract: Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are N&agr;(&ohgr;-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N&agr;(&ohgr;-functionalized) amino acids are incorporated into a peptide sequence, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is specifically exemplified by backbone cyclized bradykinin antagonists having biological activity. Further embodiments of the invention are somatostatin analogs having one or two ring structures involving backbone cyclization.Type: GrantFiled: July 22, 1998Date of Patent: July 24, 2001Assignees: Yissum Research Development Co. of the Hebrew University, Peptor LimitedInventors: Chaim Gilon, Doron Eren, Irina Zeltser, Alon Seri-Levy, Gal Gitan, Dan Muller
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Patent number: 6184345Abstract: The present invention relates to building units suitable for the synthesis of backbone cyclized peptides. The building units of this invention have structures of Formula (I): X—AAm—U—AAp—Y (I) wherein AAm and AAp are residues of natural or synthetic amino acids and U is C&agr;ON[(CH2)n+1W] or &PSgr;(C&agr;H2N)[CO(CH2)qW], in which C&agr; is a carbon atom and is the &agr; carbon of AAm if m>0. W is NH—X or COY, and X is H, Boc, Z, Fmoc, or Alloc while Y is the hydroxyl group of a carboxylic acid moiety or a carboxylic acid protecting group. The letter m refers to an integer from 0 to 10; n is a number from 0 to 6; p is a number from 1 to 10; and q is a number from 1 to 6. The present invention is also directed to methods of synthesizing building units of Formula (I) via different routes.Type: GrantFiled: February 8, 1999Date of Patent: February 6, 2001Assignee: Peptor LimitedInventors: Siegmund Reissmann, Bettina Müller, Peter Kleinwächter, Diana Besser
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Patent number: 6117974Abstract: Libraries of novel backbone-cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units used in the synthesis of these backbone-cyclized peptide analogs are N(((-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N(((-functionalized) amino acids are incorporated into a library of peptide sequences, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by libraries of backbone-cyclized bradykinin analogs, somatostatin analogs, BPI analogs and Substance P analogs having biological activity.Type: GrantFiled: December 7, 1995Date of Patent: September 12, 2000Assignees: Peptor Limited, Yissum Research Development Company of The Hebrew University in JerusalemInventors: Chaim Gilon, Vered Hornik
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Patent number: 6051554Abstract: Novel peptides which are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions are disclosed.Type: GrantFiled: June 19, 1998Date of Patent: April 18, 2000Assignee: Peptor LimitedInventors: Vered Hornik, Gary Gellerman, Mich El M Afargan
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Patent number: 5811392Abstract: Novel backbone cyclized peptide analogs are formed by means of bridging groups attached via the alpha nitrogens of amino acid derivatives to provide novel non-peptidic linkages. Novel building units disclosed are N.sup..alpha. (.omega.-functionalized) amino acids constructed to include a spacer and a terminal functional group. One or more of these N.sup..alpha. (.omega.-functionalized) amino acids are incorporated into a peptide sequence, preferably during solid phase peptide synthesis. The reactive terminal functional groups are protected by specific protecting groups that can be selectively removed to effect either backbone-to-backbone or backbone-to-side chain cyclizations. The invention is exemplified by backbone cyclized bradykinin antagonists having biological activity. Further embodiments of the invention are somatostatin analogs having one or two ring structures involving backbone cyclization.Type: GrantFiled: June 7, 1995Date of Patent: September 22, 1998Assignees: Yissum research Development Co. of the Hebrew University, Peptor LimitedInventors: Chaim Gilon, Doron Eren, Irina Zeltser, Alon Seri-Levy, Gal Bitan, Dan Muller
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Patent number: 5770687Abstract: Novel peptide analogs are disclosed. The novel peptides are conformationally constrained backbone cyclized somatostatin analogs. Methods for synthesizing the somatostatin analogs and for producing libraries of the somatostatin analogs are also disclosed. Furthermore, pharmaceutical compositions comprising somatostatin analogs, and methods of using such compositions in the treatment of endocrine disorders, neoplasms and metabolic disorders are also disclosed.Type: GrantFiled: July 31, 1996Date of Patent: June 23, 1998Assignees: Peptor Limited, Yissim Research Development Co. of Hebrew University of JerusalemInventors: Vered Hornik, Alon Seri-Levy, Gary Gellerman, Chaim Gilon