Patents Assigned to PerkinElmer LAS, Inc.
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Patent number: 7351529Abstract: Disclosed are methods for identifying genetic mosaicisms in cell populations. Suitable cell populations include, e.g., biopsy or body fluid samples or cultures of cancer cells. The method includes performing array-based comparative genomic hybridization (CGH), wherein a plurality of cloned genomic nucleic acid segments is provided in a plurality of identical replicas, each cloned segment immobilized to a discrete and known spot on a substrate surface to form the array, and the cloned genomic nucleic acid segments comprise a substantially complete first genome of a known first karyotype. The invention also provides methods for optimizing performance of an array-based comparative genomic hybridization (CGH).Type: GrantFiled: September 27, 2002Date of Patent: April 1, 2008Assignee: PerkinElmer LAS, Inc.Inventor: Mansoor Mohammed
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Patent number: 7335338Abstract: A method and apparatus are provided for automatically sensing the presence (or absence) of spot dispensers such as pins in various possible mounting locations in the printhead of a microarray spotting instrument. Pin-location data obtained by the method and apparatus is provided to the computer controller of the instrument, which uses the data to control the motion of the printhead during operation of the instrument. A pin detection apparatus includes one or more sensor elements that automatically sense possible pin locations in the printhead for the presence of pins. The sensor elements are preferably arranged in an array corresponding to the array of pin locations in the printhead so that pin detection at each pin location can be performed simultaneously. Various types of sensor elements can be used to locate pins in a printhead. For example, sensors can be used that are remote from or attached to a printhead.Type: GrantFiled: April 11, 2005Date of Patent: February 26, 2008Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, C. Brian Candiloro
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Patent number: 7335470Abstract: In one aspect the invention provides compilations of nucleic acids, articles of manufacture, e.g., arrays, and methods for the detection of chromosomal abnormalities, such as a chromosomal aneuploidies, deletions, amplifications, and the like, and the diagnosis or prognosis of syndromes associated with a contiguous gene abnormality. Kits are also provided.Type: GrantFiled: October 15, 2002Date of Patent: February 26, 2008Assignee: PerkinElmer, LAS, Inc.Inventors: Mansoor Mohammed, Jason Kang, Shishir Shah, Wei-Wen Cai
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Publication number: 20080035476Abstract: The invention relates to an electrochemical gas generator including a substrate for providing a surface for electrode deposition, a first electrode deposited on the surface for providing an electrical connection with a conducting medium, a second electrode deposited on the substrate for generating a gas, and a plurality of members extending from at least one side of the first electrode placed alternately with a plurality of extensions protruding from at least one side of the second electrode for improving generator efficiency.Type: ApplicationFiled: October 19, 2007Publication date: February 14, 2008Applicant: PerkinElmer LAS, Inc.Inventors: Avinash Dalmia, Otto Prohaska
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Patent number: 7328135Abstract: The invention relates to a web-based instrument interface including software executing on an instrument controller computer system that receives a web file from a web browsing software executing on a remote computer. The web-based interface also extracts a command or a request for status information from the web file, generates and transmits to an analytical instrument a signal indicative of the extracted command or request for status information, receives a signal from the analytical instrument indicative of the status thereof, and generates and transmits to the web browsing software executing on the remote computer a web file based upon the received signal from the analytical instrument indicative of the status thereof.Type: GrantFiled: May 27, 2004Date of Patent: February 5, 2008Assignee: PerkinElmer LAS, Inc.Inventors: Richard Linley, John A. Olbert
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Publication number: 20080026408Abstract: The disclosure features, inter alia, methods and compositions for detecting, isolating, and/or analyzing one or more analytes such as, but not limited to, biomolecules (e.g., proteins, glycoproteins, lipids (e.g., sphingolipids), and carbohydrates). Such methods and compositions are useful in, e.g., the discovery of novel proteins, or the amino acid sequence of novel proteins, or identifying biomarkers for diseases such as cancer, immunological disorders, or microbial infections.Type: ApplicationFiled: July 2, 2007Publication date: January 31, 2008Applicant: PerkinElmer LAS, Inc.Inventors: Wayne Patton, Thomas Miller, Nan Jiang, Michael O'Malley
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Patent number: 7311757Abstract: An analyte pre-concentrator for gas chromatography is disclosed generally comprising a tube having a restricted outlet and packed with an adsorbent, wherein the tube serves as the liner of a chromatographic injector, as an adsorbent trap coupled to a chromatographic column, and/or as an adsorbent trap coupled to a headspace sampler. Preferably, a heating device allows the tube to be heated. In a preferred embodiment, the analyte pre-concentrator further comprises a column isolating accessory so that a chromatographic column can be temporarily isolated from substances flowing through the tube.Type: GrantFiled: September 22, 2005Date of Patent: December 25, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Andrew Tipler, Gary Campbell, Mark Collins
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Publication number: 20070291262Abstract: Methods and systems are disclosed that include an optical device for providing information about one or more samples. The system includes well(s) for holding the sample(s), and in one embodiment, the optical device(s) have non-parallel sidewalls optically contacting the well(s) for providing the information about the sample(s) in the well(s). In some embodiments the optical devices may be truncated prism(s). In some embodiments the optical devices are part of a unibody structure with the well(s).Type: ApplicationFiled: May 31, 2007Publication date: December 20, 2007Applicant: PerkinElmer LAS, Inc.Inventor: Carl Candiloro
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Patent number: 7300564Abstract: The invention relates to an electrochemical gas generator including a substrate for providing a surface for electrode deposition, a first electrode deposited on the surface for providing an electrical connection with a conducting medium, a second electrode deposited on the substrate for generating a gas, and a plurality of members extending from at least one side of the first electrode placed alternately with a plurality of extensions protruding from at least one side of the second electrode for improving generator efficiency.Type: GrantFiled: September 28, 2004Date of Patent: November 27, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Avinash Dalmia, Otto J. Prohaska
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Patent number: 7291474Abstract: Disclosed are compounds of the general formulas: wherein Y is a moiety capable of being cleaved by a hydrolytic enzyme; L is a detectable label; X is a linking group; Z is a halogen; and R is hydrogen, an alkyl, or a halogen. Compounds of this general formula can be used as substrates in an analyte-dependent enzyme activation system, such as that employed in connection with catalyzed reporter depositions. Also disclosed are assays using the compounds, and kits for carrying out the assays.Type: GrantFiled: June 10, 2004Date of Patent: November 6, 2007Assignee: PerkinElmer LAS, Inc.Inventor: Mark N. Bobrow
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Publication number: 20070251824Abstract: The invention relates to methods for isolating an analyte of interest in a sample suspected of containing the analyte of interest using two-dimensional planar electrochromatography. The methods comprise treating at least a portion of the sample with a mobility modifier capable of modifying the mobility of the analyte of interest after the second dimension of planar electrochromatography. Kits and compositions are also disclosed.Type: ApplicationFiled: January 24, 2007Publication date: November 1, 2007Applicant: PerkinElmer LAS, Inc.Inventors: Wayne Patton, Linan Song, Nancy Wilker
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Patent number: 7284410Abstract: Disclosed are systems and methods that include a thermal desorption unit, a chromatographic column, and an interface device between the unit and the column. The interface device controls the fluid flowing into the column, such as by providing additional carrier gas to maintain a substantially constant gas flow or velocity, by proving a controlled temperature increase, or by venting a portion of the gas received from the thermal desorption unit, thereby removing the dependence on the thermal desorption unit for such control. In some embodiments, the interface is a chromatographic injector. In certain embodiments, a transfer line from the desorption unit is coupled to the same port of the interface device as the chromatographic column. In some of these embodiments, this is accomplished by employing a special adaptor.Type: GrantFiled: June 29, 2005Date of Patent: October 23, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Andrew Tipler, Heidi Grecsek, Frank DeLorenzo, Giuseppe Coppola
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Patent number: 7271885Abstract: Detection apparatus for performing surface plasmon resonance (SPR) measurements on a sample includes a support having side walls and a bottom wall defining a plurality of adjacent wells. The bottom wall has integrated therein SPR detectors underlying the wells for detecting the refractive indexes of samples deposited in the wells. Each SPR detector includes a prism having an exterior entrance surface, an exterior exit facet and an interior sensing surface located at the bottom of the overlying well, and a thin metal layer coated on the sensing surface. The prism may be molded from a transparent polymer into the bottom of a standard-format microplate structure. That structure may be used in conjunction with an SPR measuring or reading instrument to perform label-less assay measurements on various samples in an efficient and reliable manner. A method of acquiring the assay measurements is also disclosed.Type: GrantFiled: March 25, 2005Date of Patent: September 18, 2007Assignee: Perkinelmer LAS, Inc.Inventor: Mack Schermer
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Patent number: 7267709Abstract: Disclosed are systems and methods that include providing a vessel having an adsorbent disposed therein, the vessel having an inlet and an outlet for communicating a carrier gas through the vessel; determining a differential pressure between the inlet and the outlet for a known flow rate at the outlet; and, determining a geometric measure for the vessel based on a ratio of the known flow rate and the differential pressure. In some embodiments, the methods and systems can include a viscosity in the ratio, determining a flow rate at ambient pressure using a factor based on a ratio of a gas pressure at the output and ambient pressure, and/or, determining a flow rate at ambient temperature using a factor based on a ratio of a temperature at the output and ambient temperature.Type: GrantFiled: November 14, 2006Date of Patent: September 11, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Andrew Tipler, Neil T. Plant
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Publication number: 20070178530Abstract: The technology described herein relates to methods of detecting or predicting pre-eclampsia (PE). The technology described herein also relates to commercial packages, such as diagnostic kits, for performing a method of detecting or predicting PE. In particular, the technology described herein provides methods of predicting pre-eclampsia when determining the levels of biochemical markers.Type: ApplicationFiled: January 16, 2007Publication date: August 2, 2007Applicant: PerkinElmer LAS, Inc.Inventors: Lucilla Poston, Andrew Shennan
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Publication number: 20070166810Abstract: This invention relates to methods and compositions useful in detecting enzymatic activity. Also featured are methods for diagnosing enzyme deficiencies such as metabolic disorders.Type: ApplicationFiled: December 22, 2006Publication date: July 19, 2007Applicant: PERKINELMER LAS, INC.Inventors: Mark Bobrow, Karl Adler, Mack Schermer
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Publication number: 20070166835Abstract: Disclosed herein are methods and compositions for multiplexed assays using magnetic and non-magnetic particles. Also disclosed are methods and compositions for performing multi-step assays within a single assay vessel.Type: ApplicationFiled: December 22, 2006Publication date: July 19, 2007Applicant: PERKINELMER LAS, INC.Inventors: Mark Bobrow, Karl Adler, Mack Schermer
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Publication number: 20070166739Abstract: Disclosed herein are methods and compositions for evaluating genomic content using encoded particles to evaluate multiple samples in parallel.Type: ApplicationFiled: December 22, 2006Publication date: July 19, 2007Applicant: PERKINELMER LAS, INC.Inventors: Mark Bobrow, Karl Adler, Mack Schermer
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Patent number: 7237430Abstract: The invention includes a method and apparatus for a chromatography system having a chromatographic column for separating gases in a mixture from one another and an electrochemical gas sensor coupled to the chromatographic column for detecting a gas being emitted from the column. The electrochemical gas sensor further includes a substrate having a surface for depositing electrodes thereon, an ionomer membrane in contact with the surface, an electrode in contact with the surface, and an opening in the ionomer membrane in a location proximate to the electrode for permitting a gas to diffuse through the opening to simultaneously contact the electrode and the ionomer membrane within the opening.Type: GrantFiled: November 17, 2005Date of Patent: July 3, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Otto J. Prohaska, Avinash Dalmia, Andrew Tipler
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Patent number: 7233391Abstract: Methods and systems are disclosed that include an optical device for providing information about one or more samples. The system includes well(s) for holding the sample(s), and in one embodiment, the optical device(s) have non-parallel sidewalls optically contacting the well(s) for providing the information about the sample(s) in the well(s). In some embodiments the optical devices may be truncated prism(s). In some embodiments the optical devices are part of a unibody structure with the well(s).Type: GrantFiled: November 12, 2004Date of Patent: June 19, 2007Assignee: PerkinElmer LAS, Inc.Inventors: Mack J. Schermer, Carl Brian Candiloro