Patents Assigned to Pharmacore, Inc.
  • Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
    Patent number: 7507830
    Abstract: Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: March 24, 2009
    Assignee: Pharmacore, Inc.
    Inventor: Joseph A. Miller
  • Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
    Patent number: 7105707
    Abstract: Mono- and disubstituted aryl or heterocyclic acetylenes are produced by a process comprising reacting an aryl nitrile with an alkynylzinc compound, a bis-alkynylzinc compound, or an alkynylmagnesium compound, in the presence of a nickel/phosphine catalyst.
    Type: Grant
    Filed: December 17, 2003
    Date of Patent: September 12, 2006
    Assignee: PharmaCore, Inc.
    Inventors: Joseph A. Miller, Jonathan M. Penney
  • Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
    Patent number: 7105467
    Abstract: The present invention provides nickel catalysts and solvents which are useful in a cross-coupling reaction between an organomagnesium compound and an aromatic ether compound, such as an anisole derivative.
    Type: Grant
    Filed: July 8, 2003
    Date of Patent: September 12, 2006
    Assignee: Pharmacore, Inc.
    Inventor: John W. Dankwardt
  • Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
    Patent number: 6962999
    Abstract: Methods are provided for the construction of unsymmetrical biaryl compounds and alkylated aromatic compounds from arylnitriles using a nickel or palladium catalyzed coupling in which the catalyst has at least one phosphine or phosphite ligand.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: November 8, 2005
    Assignee: Pharmacore, Inc.
    Inventor: Joseph A. Miller
  • Multicomponent synthesis of amino acids and derivatives thereof
    Patent number: 6930200
    Abstract: Mono-substituted and di-substituted alpha-amino acids and derivatives thereof, substituted at the alpha positon with one (mono-) or two (di-) substituents (R2 and/or R3) as shown in Formula 1: N(R4R5)C(R2R3)CO(OR1).
    Type: Grant
    Filed: June 26, 2003
    Date of Patent: August 16, 2005
    Assignee: Pharmacore, Inc.
    Inventor: Adnan M. M. Mjalli
  • Amino acid derivatives
    Patent number: 6809207
    Abstract: The present invention provides certain alpha-amino acids and derivatives thereof, such as, but not limited to, esters, amides and salts. These derivatives may comprise such representative side groups as a phenyl, pyridyl, piperidinyl, tetrahydropyranyl, tetrahydrothiopyranyl, or thienyl group. The present invention further provides a method for synthesizing alpha-amino acids and derivatives thereof via a modified Ugi type reaction using an aldehyde, ammonium formate and a C1-C5 alkyl isocyanide. The compounds provided by this method are useful in the development of new pharmaceuticals for the treatment of human diseases.
    Type: Grant
    Filed: July 24, 2002
    Date of Patent: October 26, 2004
    Assignee: PharmaCore, Inc.
    Inventors: Sekar Alla, Seung-Yong Choi, Dale Dhanoa, Elso DiFranco, Galina Krokhina, Keqiang Li, Balasubramanian Thiagarajan, Wen-Chun Zhang
  • Quaternary amino acids on solid supports
    Patent number: 6713580
    Abstract: The present invention relates to novel templates useful for generating novel compounds and to compounds produced utilizing the templates. The templates comprise quaternary amino acids that may be linked to solid supports. These templates make possible the production of novel classes of chemical compounds through a plurality of chemical reactions. The templates are advantageous for use in drug discovery regimes.
    Type: Grant
    Filed: December 6, 2001
    Date of Patent: March 30, 2004
    Assignee: Pharmacore, Inc.
    Inventors: Michael Johnson, Keqiang Li, Elso DiFranco, Daljit S. Dhanoa