Abstract: Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.
Type:
Grant
Filed:
September 21, 1999
Date of Patent:
June 12, 2001
Assignees:
The Johns Hopkins University, Pharmagenics, Incs
Inventors:
Bert Vogelstein, Kenneth W. Kinzler, Michael I. Sherman
Abstract: Libraries of compounds such as nucleic acids or peptides are contacted with a target molecule and libraries that have at least one compound that bind with at least a minimum activity are determined by a reiterative process in which a change in the rate of recovery (elimination) of compounds that bind to the target indicates that the library contains such a compound. The procedure may also be used to determine indirectly the sequence of such compound by employing sublibraries, each of which have a known entity at a known position of the compound.
Abstract: Oligonucleotides and analogs thereof that bind to and preferably modulate the activity of interferon-.gamma., and methods for their use, including therapeutic and diagnostic methods are disclosed.
Type:
Grant
Filed:
March 17, 1994
Date of Patent:
February 4, 1997
Assignee:
PharmaGenics, Inc.
Inventors:
George R. Coppola, Bruce A. Beutel, Arthur H. Bertelsen
Abstract: Specific sequences in the human genome are the sites of strong binding of wild-type p53 protein, but not mutant forms of the protein. These sequences are used diagnostically to detect cells in which the amount of wild-type p53 is diminished. The sequences can also be used to screen for agents which correct for loss of wild-type p53 to DNA in cancer cells.
Type:
Grant
Filed:
March 31, 1992
Date of Patent:
November 8, 1994
Assignees:
The John Hopkins University, PharmaGenics, Inc.
Inventors:
Bert Vogelstein, Kenneth W. Kinzler, Michael I. Sherman