Abstract: The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.

Abstract: The invention disclosed herein relates to an implantable medical device for detection and treatment of syncope comprising an algorithm for determining the presence of syncope based on physiological activity associated with the onset of a syncopal episode, and a means for infusion a drug. Drug infusion therapy may be used along or in combination with pacing. The physiological activities detected and used by the device are selected from the group including changes in heart rate, heart rate variability, QT interval, PR interval, pressure, blood flow, vagal nerve activity, temperature, pH, and AV conduction times, respiration rate, position, motion, and combinations thereof. Drugs which may be used with the invention include pharmaceutical compositions which are capable of both endocardial administration and treatment of syncope, such as compositions comprising beta-blockers.

Abstract: A catheter for use with an implantable drug dispensing arrhythmia control device, includes a lumen and valve for dispensing the drug, and multiple electrodes for sensing heart activity.

Abstract: An atrial catheter for insertion into the coronary sinus carries free-floating sensing electrodes and one or more pacing electrodes in contact with the tissue of the coronary sinus.

Abstract: An implantable programmable drug delivery system for injection of a pharmaceutical agent into the peritoneum to treat cardiac arrhythmia is described. The device consists of essentially three components: a main body containing electronics, power supply, valve means, and drug reservoir; an electronic lead into the heart to transmit impulses from the heart and deliver electronic responses to the heart; and a separate specialized drug delivery catheter for delivery of agents to the peritoneal cavity or near the exterior of the pericardium.