Patents Assigned to Phenolics, LLC
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Publication number: 20230414690Abstract: Methods for preparing compositions highly enriched in phenolic compounds from plant materials that naturally contain phenolic compounds such as anthocyanins and proanthocyanidins are enriched for a wide spectrum of phenolic compounds and consist of phenolic compounds including monomers, dimers, trimers, oligomers and polymers >3000 amu and over 35% concentrated total phenols. The compositions of the present disclosure which include phenolic compounds including monomers, dimers, trimers, oligomers and polymers >3000 amu and over 35% concentrated total phenols optionally include trisodium citrate and/or cyclodextrin.Type: ApplicationFiled: June 22, 2023Publication date: December 28, 2023Applicant: Phenolics, LLCInventors: Michael S. Tempesta, F. Joseph Daugherty
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Publication number: 20230055210Abstract: Formulations of creatine, preferably phosphocreatine and most preferably disodium phosphocreatine, combined with cyclodextrin exhibit improved uptake across digestive mucosa, including intestinal, esophageal, and stomach mucosa. In particular, the formulations of the present invention are designed for protection of the creatine as they come in contact with gastric juices so as to allow thereafter for unexpectedly improved site-specific intestinal release.Type: ApplicationFiled: October 21, 2022Publication date: February 23, 2023Applicant: Phenolics, LLCInventors: Michael S. Tempesta, F. Joseph Daugherty
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Publication number: 20220338519Abstract: Oral supplements containing phenolic compounds such as those present in Vaccinium and/or Sambucus, as well as other genera are enriched in total phenols and combined with either organic acid sodium salts and/or phosphocreatine salts are shown to have enhanced absorption properties. When taken together in an oral supplement, the particular phenolic compound(s) found in such extracts and in other genera containing significant quantities of total phenols are believed to enhance the activity of the phosphocreatine salts in a synergistic manner and result in enhancement of physical activity as well as provide recovery from inflammation.Type: ApplicationFiled: April 8, 2022Publication date: October 27, 2022Applicant: Phenolics, LLCInventors: F. Joseph Daugherty, Michael S. Tempesta
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Publication number: 20210361731Abstract: The oral supplements of the present invention utilize phenolic compounds in combination with creatine, choline, and trisodium citrate, wherein when taken together result in enhanced cellular permeation in comparison to cellular permeation in the absence of the other compounds of the combination leading to improved brain and/or physical functioning.Type: ApplicationFiled: May 20, 2021Publication date: November 25, 2021Applicant: Phenolics, LLCInventors: F. Joseph Daugherty, Michael S. Tempesta
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Patent number: 7682637Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.Type: GrantFiled: August 7, 2007Date of Patent: March 23, 2010Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20090099373Abstract: This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.Type: ApplicationFiled: October 30, 2008Publication date: April 16, 2009Applicant: PHENOLICS, LLCInventors: David T. BAILEY, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
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Publication number: 20090035226Abstract: Cranberry and other plant extracts enriched in total phenols and free or substantially free of sugars, acids, sulfur and other contaminants are used for periodontal treatments. The periodontal treatments of the present invention include swish and swallow techniques, in which the extracts enriched in total phenols but free or substantially free of sugars, acids, sulfur and other contaminants, are solubilized in water or other solvent, placed in the mouth, swished around the teeth and then swallowed. Other application techniques include gel applications, gum formulations and toothpaste formulations.Type: ApplicationFiled: July 31, 2008Publication date: February 5, 2009Applicant: PHENOLICS, LLCInventors: Michael S. TEMPESTA, F. Joseph Daugherty
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Patent number: 7462370Abstract: This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.Type: GrantFiled: May 18, 2007Date of Patent: December 9, 2008Assignee: Phenolics, LLCInventors: David T. Bailey, Delano R. Freeberg, Dennis Gertenbach, Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, F. Joseph Daugherty
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Publication number: 20080207770Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.Type: ApplicationFiled: November 30, 2007Publication date: August 28, 2008Applicant: PHENOLICS, LLCInventors: Gerald T. GOURDIN, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20080199548Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.Type: ApplicationFiled: August 7, 2007Publication date: August 21, 2008Applicant: PHENOLICS, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Patent number: 7306815Abstract: Provided are processes for the preparation of compositions enriched in phenolic compounds from a crude plant extract. One process includes a novel column purification step using a polymer resin that releasably adsorbs the phenolic compounds but does not retain polar non-phenolic compounds, wherein the resin comprises aromatic rings substituted with one or more electron-withdrawing groups. This invention also includes compositions enriched in phenolic compounds. This invention encompasses methods of using the phenolic-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease. The compositions are also useful as meat additives to inhibit food-borne pathogens.Type: GrantFiled: January 23, 2004Date of Patent: December 11, 2007Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg
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Publication number: 20070269536Abstract: This invention provides compositions enriched for anthocyanins and methods of preparation thereof from a crude plant extract. The method of preparation includes a novel column purification step using a brominated polystyrene resin.Type: ApplicationFiled: May 18, 2007Publication date: November 22, 2007Applicant: PHENOLICS, LLCInventors: David Bailey, Delano Freeberg, Dennis Gertenbach, Gerald Gourdin, Steven Richheimer, Michael Tempesta, F. Daugherty
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Publication number: 20060280816Abstract: A product made by a process which results in compositions enriched in total phenols includes purification steps not involving the addition of bisulfite ions. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols, total phenol concentration >12% and exhibiting in vitro COX-2 inhibitory activity enhanced by a factor of at least 2.5 over a standard aspirin dose of 660 ?g/mL.Type: ApplicationFiled: August 22, 2006Publication date: December 14, 2006Applicant: PHENOLICS, LLCInventors: Gerald Gourdin, Steven Richheimer, Michael Tempesta, David Bailey, Rebecca Nichols, F. Daugherty, Delano Freeberg
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Patent number: 6960360Abstract: This invention provides a process for the preparation of compositions enriched in total phenols from a crude plant extract. The process includes a novel column purification step using a brominated polystyrene resin. This invention also includes compositions enriched in total phenols. The enriched compositions are characterized as containing monomeric, oligomeric and polymeric phenols and having HPLC chromatograms substantially as set forth in FIGS. 10-13. This invention encompasses methods of using the total phenol-enriched compositions for treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyoxovaridae such as influenza A, B, and C, parainfluenza, Herpes viruses such as HSV-1 and HSV-2, and Flaviviruses such as West Nile Virus, and for treating inflammation such as caused by arthritis, stress and digestive disease.Type: GrantFiled: November 22, 2002Date of Patent: November 1, 2005Assignee: Phenolics, LLCInventors: Gerald T. Gourdin, Steven L. Richheimer, Michael S. Tempesta, David T. Bailey, Rebecca L. Nichols, F. Joseph Daugherty, Delano R. Freeberg