Patents Assigned to Phoenix Chemicals Limited
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Publication number: 20140051869Abstract: A continuous process for producing compounds having the general formula (6) is provided: wherein R is a straight or branched chain alkyl group, R1 is a straight or branched chain alkyl group substituted with a nitrile group, a hydroxy group or a halogen atom, R2 is a hydroxy group or a keto group, and each R3 is, independently, hydrogen or a straight or branched chain alkyl group, comprising providing a continuous stream of an alkyl acetate and a continuous stream of an alkali metal or alkaline earth metal amide base and contacting the continuous streams to yield an enolate compound, providing a continuous stream of a compound of formula (5): wherein R1 is as previously defined, and contacting the continuous stream of compound (5) with a continuous stream of the enolate above 20° C. to yield an intermediate compound and treating the intermediate compound with an acid.Type: ApplicationFiled: October 25, 2013Publication date: February 20, 2014Applicant: Phoenix Chemicals LimitedInventors: Peter McCormack, Antony John Warr, Elliot Latham
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Publication number: 20120309989Abstract: The invention concerns A continuous process for the production of compounds having the general formula (6): wherein R is a straight or branched chain alkyl group, R1 is a straight or branched chain alkyl group substituted with a nitrile group, a hydroxy group or a halogen atom, R2 is a hydroxy group or a keto group, and each R3 is, independently, hydrogen or a straight or branched chain alkyl group, comprising providing to a reaction zone a continuous stream of an alkyl acetate and a continuous stream of an alkali metal or alkaline earth metal amide base and contacting the continuous streams together in the reaction zone to yield an enolate compound, providing to the or a separate reaction zone a continuous stream of a compound of formula (5): wherein R1 is as previously defined, and contacting the continuous stream of compound (5) with a continuous stream of the enolate (4) in the or the separate reaction zone at a temperature above 20° C.Type: ApplicationFiled: October 22, 2010Publication date: December 6, 2012Applicant: PHOENIX CHEMICALS LIMITEDInventors: Peter McCormack, Antony John Warr, Elliot Latham
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Patent number: 8143406Abstract: The invention provides a process for the manufacture of HI 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl)ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protected HI 6 product precursor, and de-protecting the precursor to form HI 6 dimethanesulfonate.Type: GrantFiled: August 22, 2007Date of Patent: March 27, 2012Assignee: Phoenix Chemicals LimitedInventors: Jonathan Eddolls, Peter McCormack, Anne Hodgson
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Publication number: 20100094038Abstract: The present invention provides a method of preparing a sulfonyl ether comprising the steps of: v) reacting a sulfonic acid with an anhydride, under continuous vacuum distillation conditions, to form a carboxysulfonate; vi) reacting the carboxysulfonate with an optionally substituted cycloalkane ring containing at least 3 heteroatoms to form a sulfonyl ether pre-mix comprising a sulfonyl ether and at least two additional reaction products each containing at least one ether linkage; vii) subjecting the pre-mix to continuous vacuum distillation conditions to remove at least some of the additional reaction products from the sulfonyl ether pre-mix to provide a crude sulfonyl ether product; and viii) purifying the crude sulfonyl ether product.Type: ApplicationFiled: January 8, 2008Publication date: April 15, 2010Applicant: PHOENIX CHEMICALS LIMITEDInventors: Antony Warr, Peter McCormack, Jonathan Eddolls, Elliot Latham
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Publication number: 20100016604Abstract: The invention provides a process for the manufacture of H1 6 dimethanesulfonate comprising contacting an O-protected pyridine aidoxime compound with bis(methylsulphonoxymethyl)ether in a suitable solvent to form an intermediate compound, contacting said intermediate compound with isonicotinamide to form an O-protected HI 6 product precursor, and de-protecting the precursor to form HI 6 dimethanesulfonate.Type: ApplicationFiled: August 22, 2007Publication date: January 21, 2010Applicant: PHOENIX CHEMICALS LIMITEDInventors: Jonathan Eddolls, Peter Mccormack, Anne Hodgson
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Patent number: 7531683Abstract: The present invention relates to a continuous process for the cyanation of hydrogenated ?-ketoesters in a cyanation zone maintained under conditions of temperature and pressure effective for cyanation of a hydrogenated R-ketoester. A substrate comprising a hydrogenated ?-ketoester is continuously supplyed to the cyanation zone together with a cyanide. The substrate is contacted with the cyanide in the cyanation zone for a period effective for at least partial cyanation of the hydrogenated ?-ketoester and a product stream is continuously extracted from the cyanation zone.Type: GrantFiled: May 21, 2003Date of Patent: May 12, 2009Assignee: Phoenix Chemicals LimitedInventors: Lee David Proctor, Anthony John Warr
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Publication number: 20080281106Abstract: The present invention relates to process for the production of chiral ligands comprising providing a starting material of Formula (A): wherein X* is a chiral or achiral directing group; and (i) is an optionally substituted mono- or polycyclic aryl or cycloalkyl group; ortholithiating the substrate; converting the ortho-lithiated substrate to a phosphine group having the formula —PR1R1?, R1 being selected from substituted and unsubstituted, branched- and straight-chain alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted carbocyclic aryl, and substituted and unsubstituted heteroaryl wherein the or each heteroatom is independently selected from sulphur, nitrogen, and oxygen, R1? being different from R1 and being selected from substituted and unsubstituted, branched- and straight-chain alkyl, substituted and unsubstituted cycloalkyl, substituted and unsubstituted carbocyclic aryl, and substituted and unsubstituted heteroaryl wherein the or each heteroatom is independently selected fromType: ApplicationFiled: January 14, 2005Publication date: November 13, 2008Applicant: PHOENIX CHEMICALS LIMITEDInventors: Wei-Ping Chen, John Whittall
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Publication number: 20070183957Abstract: The invention relates to a process for the production of chloramine comprising supplying a first reagent stream comprising chlorine gas and a second reagent stream comprising ammonia gas to a reaction zone maintained at a temperature of less than 275° C. and configured to allow expansion of the first and second reagent streams in the reaction zone to an extent sufficient to generate chloramine as a gas and ammonium chloride as a free falling solid. The invention also provides a chemical reactor suitable fur operating this process.Type: ApplicationFiled: October 18, 2004Publication date: August 9, 2007Applicant: PHOENIX CHEMICALS LIMITEDInventors: Antony Warr, Lee Proctor
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Publication number: 20070161762Abstract: The present invention relates to metallocene-based phosphine ligands having chirality at phosphorus and at least one other element of chirality (planar chirality and/or chirality at carbon); and to the use of such ligands in asymmetric transformation reactions to generate high enantiomeric excesses of formed compounds. A method for the preparation of ligands according to the invention involving the conversion of the ortho-lithiated substituted metallocene to a phosphine chiral at phosphorus is also disclosed.Type: ApplicationFiled: January 14, 2005Publication date: July 12, 2007Applicant: Phoenix Chemicals LimitedInventors: Wei-Ping Chen, John Whittall
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Patent number: 7057064Abstract: The present invention relates to a continuous process for the enantioselective catalytic hydrogenation of ?-ketoesters comprising providing a catalytic hydrogenation zone and maintaining it under conditions of temperature and pressure effective for the catalytic hydrogenation of ?-ketoesters; continuously supplying to the catalytic hydrogenation zone a substrate comprising a ?-ketoester to be hydrogenated, a catalyst effective for enantioselective hydrogenation of the ?-ketoester and hydrogen; contacting the substrate, the catalyst and the hydrogen in the hydrogenation zone for a residence time effective for at least partial enantioselective catalytic hydrogenation of the ?-ketoester; (d) continuously withdrawing from the hydrogenation zone a reaction product mixture comprising enantioselectively hydrogenated ?-ketoester, unreacted ?-ketoester, catalyst and hydrogen; (e) supplying the reaction product mixture to a separation zone and separating at least some of the enantioselectively hydrogenated ?-ketoesterType: GrantFiled: May 21, 2003Date of Patent: June 6, 2006Assignee: Phoenix Chemicals LimitedInventors: Lee David Proctor, Anthony John Warr
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Patent number: 6962983Abstract: A method for the production of diazomethane comprising the steps of a) feeding a base and a diazomethane precursor into a reactor vessel; b) generating gaseous diazomethane by allowing the base and the gaseous diazomethane precursor to react; and c) removing the gaseous diazomethane using a diluent gas.Type: GrantFiled: December 15, 2000Date of Patent: November 8, 2005Assignee: Phoenix Chemicals LimitedInventors: Antony John Warr, Lee Proctor
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Patent number: 6693205Abstract: The invention concerns a process for the production of optically active epoxides useful as pharmaceutical intermediates, particularly in the field of HIV protease inhibitors. The optically active epoxides are produced in commercially acceptable yields from an optically active alcohols by a Mitsunobu reaction and a cyclisation step, preferably comprising an intermediate re-crystallisation step. The stereochemistry of the alcohol is inverted during the Mitsunobu reaction to produce the desired epoxide.Type: GrantFiled: January 10, 2003Date of Patent: February 17, 2004Assignee: Phoenix Chemicals LimitedInventor: David Edward Justice