Patents Assigned to Photogenesis, Inc.
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Patent number: 7189245Abstract: An implantation device having a reservoir for holding a solid or semisolid implant and a carrier fluid, wherein the reservoir includes a cannula. The cannula has a tip end and a delivery opening therein both shaped and dimensioned to suit the application. For example, an implant (such as a retinal cell graft) and suitable carrier fluid (such as an aqueous hyaluronic acid solution) can be expressed from the opening into the subretinal space of a recipient eye, provided the cannula is of sufficient length that the tip end can reach the subretinal space while the remainder of the fluid reservoir is external of the eye. Expression of the carrier fluid from the reservoir via the delivery opening expels the implant through the delivery opening. An electromechanically driven plunger apparatus with operator controls is provided in a preferred embodiment.Type: GrantFiled: February 14, 2003Date of Patent: March 13, 2007Assignee: Photogenesis, Inc.Inventor: Henry J. Kaplan
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Patent number: 6955809Abstract: Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.Type: GrantFiled: December 17, 2002Date of Patent: October 18, 2005Assignee: Photogenesis, Inc.Inventor: Stephen E. Hughes
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Patent number: 6579256Abstract: An instrument for subretinal implantation comprising an elongate tube having a distal end and a proximal end, the tube having a lumen passing from the proximal end to the distal end, the distal end having a distal tip, wherein the lumen forms an opening in the tip, the instrument further including a plunger, the plunger being capable of sliding motion within and with respect to the tube, wherein the outer diameter of the distal end of the elongate tube is sufficiently small to be inserted through the pars plana area of an eye and the length of the distal end of the elongate tube is sufficient long to permit the opening in said tip to thereafter be inserted beneath the retina through an opening therein, wherein the plunger can express material within the lumen therefrom through the opening in the tip into the subretinal space of an eye into which the tip is inserted.Type: GrantFiled: October 4, 1999Date of Patent: June 17, 2003Assignee: Photogenesis, Inc.Inventor: Stephen E. Hughes
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Publication number: 20030054023Abstract: A method of transplanting a graft in the subretinal area of a host eye comprises preparing the graft by harvesting from the donor tissue a population of cells in a manner that maintains the population of cells in the same organization and cellular polarity as is present in normal tissue of that type. The population of cells are of a sheet-like form and are assembled with a relatively thin flexible pliable carrier composed of a non-toxic flexible composition which substantially dissolves at body temperature to form a graft. The graft is sufficiently flexible and pliable to be coiled to form a volute (76) without disturbing the organization and polarity of the cells. The method further comprises coiling the graft to form a volute (76) with the convolutions of the volute (76) free of one another for subsequent uncoiling of the graft substantially to its original sheet-like form. An incision is made in the host eye for insertion of the volute (76).Type: ApplicationFiled: October 31, 2002Publication date: March 20, 2003Applicant: PHOTOGENESIS, INC.Inventor: Stephen E. Hughes
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Patent number: 6514238Abstract: A method of transplanting a graft in the subretinal area of a host eye comprises preparing the graft by harvesting from the donor tissue a population of cells in a manner that maintains the population of cells in the same organization and cellular polarity as is present in normal tissue of that type. The population of cells are of a sheet-like form and are assembled with a relatively thin flexible pliable carrier composed of a non-toxic flexible composition which substantially dissolves at body temperature to form a graft. The graft is sufficiently flexible and pliable to be coiled to form a volute without disturbing the organization and polarity of the cells. The method further comprises coiling the graft to form a volute with the convolutions of the volute free of one another for subsequent uncoiling of the graft substantially to its original sheet-like form. An incision is made in the host eye for insertion of the volute.Type: GrantFiled: June 5, 1995Date of Patent: February 4, 2003Assignee: Photogenesis, Inc.Inventor: Stephen E. Hughes
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Patent number: 6316465Abstract: Methods of treating diseases of ocular tissues expressing the nuclear receptor PPAR&ggr;, by inhibiting the inflammatory response, the neovascularization and angiogenesis, and programmed cell death (apoptosis) in these target tissues, comprising administering to a human or animal in need of treatment an effective amount of a compound that modifies the activity of PPAR&ggr;, or pharmaceutically acceptable salts and solvates thereof.Type: GrantFiled: June 28, 1999Date of Patent: November 13, 2001Assignee: Photogenesis, Inc.Inventors: Harrihar A. Pershadsingh, Daniel E. Levy
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Patent number: 6045791Abstract: An implant is provided for transplantation to the subretinal area of a host's eye comprising a laminate of a monolayer of retinal pigment epithelium (RPE) cells and a non-toxic, flexible support that, upon exposure to a set of predetermined conditions, will not impede normal eye tissue function. A method for preparing a population of RPE cells for transplantation to the subretinal area of a host eye is also provided. The method includes the steps of providing donor tissue comprising RPE cells, harvesting from that tissue RPE cells, and apposing the harvested RPE cells as a monolayer to a non-toxic, flexible support that, upon transplantation to the subretinal area and exposure to a set of predetermined conditions, will not impede normal eye tissue function of the host eye and the transplanted population.Type: GrantFiled: May 19, 1995Date of Patent: April 4, 2000Assignee: Photogenesis, Inc.Inventor: Yao Liu
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Patent number: 6036678Abstract: A method for transplanting planar implants, devices, etc., is provided. Method is particularly adapted for transplanting planar sheets of retinal cells to the subretinal region of an eye. A method of preparing the retinal cell sheet and the associated surgical instrument is also provided.Type: GrantFiled: January 15, 1998Date of Patent: March 14, 2000Assignee: Photogenesis, Inc.Inventor: John Giungo
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Patent number: 5962027Abstract: Surgical instruments, surgical techniques, grafts, cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors, retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.Type: GrantFiled: October 13, 1994Date of Patent: October 5, 1999Assignee: Photogenesis, Inc.Inventor: Stephen E. Hughes
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Patent number: 5868728Abstract: A linear actuator assembly for operating a plurality of surgical tools. The actuator can provide motive power to a plurality of different surgical tools which are attachable to a handpiece associated with the actuator assembly and may be foot pedal operated.Type: GrantFiled: February 28, 1995Date of Patent: February 9, 1999Assignee: Photogenesis, Inc.Inventors: John Giungo, Daniel B. Schein
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Patent number: 5817075Abstract: A method for transplanting planar implants, devices, etc., is provided. Method is particularly adapted for transplanting planar sheets of retinal cells to the subretinal region of an eye. A method of preparing the retinal cell sheet and the associated surgical instrument is also provided.Type: GrantFiled: February 28, 1995Date of Patent: October 6, 1998Assignee: Photogenesis, Inc.Inventor: John Giungo