Patents Assigned to Physiosonics, Inc
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Publication number: 20140039279Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.Type: ApplicationFiled: October 10, 2013Publication date: February 6, 2014Applicants: UNIVERSITY OF WASHINGTON, PHYSIOSONICS, INC.Inventors: Jeffrey G. Jarvik, Pierre Mourad, Michel Kliot, Robert C.A. Frederickson, Abbi M McClintic, Trevor C. Dickey, Michael Gofeld
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Publication number: 20120108918Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing is employed to identify the scope and severity of chronically painful sensitized tissue areas, and of chronic pain disorders. In other applications, targeted acoustic probing is used to localize nerves and other sensitized tissues for guidance of needles and other delivery devices, and for delivery of anesthetic, analgesic or therapeutic compositions.Type: ApplicationFiled: June 15, 2011Publication date: May 3, 2012Applicant: PHYSIOSONICS, INC.Inventors: Jeffrey G. Jarvik, Pierre D. Mourad, Michel Kliot, Robert C.A. Frederickson, Abbi M. McClintic, Trevor C. Dickey, Michael Gofeld
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Publication number: 20110251489Abstract: Ultrasound monitoring systems and components used in ultrasound monitoring systems, such as Transcranial Dopper (TCD) systems, are disclosed. Components include framework systems for mounting, locating and maintaining one or more ultrasound probes in contact with an anatomical surface, adjustable probe mounting systems, and probe interface components providing an acoustically transmissive interface between a probe mounting system and the emissive face of the ultrasound probe.Type: ApplicationFiled: April 7, 2010Publication date: October 13, 2011Applicant: PHYSIOSONICS, INC.Inventors: Jimin ZHANG, Randy SERROELS, Ingrid LIN, Robert Bruce HUBLER, Joseph Patrick SULLIVAN, Paul C. LEONARD, Joel ARAGON, Luke FRYER, Harold A. BROWN, Clare LONG, Nathan J. DALE
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Patent number: 7815574Abstract: Systems and methods for noninvasive assessment of cardiac tissue properties and cardiac parameters using ultrasound techniques are disclosed. Determinations of myocardial tissue stiffness, tension, strain, strain rate, and the like, may be used to assess myocardial contractility, myocardial ischemia and infarction, ventricular filling and atrial pressures, and diastolic functions. Non-invasive systems in which acoustic techniques, such as ultrasound, are employed to acquire data relating to intrinsic tissue displacements are disclosed. Non-invasive systems in which ultrasound techniques are used to acoustically stimulate or palpate target cardiac tissue, or induce a response at a cardiac tissue site that relates to cardiac tissue properties and/or cardiac parameters are also disclosed.Type: GrantFiled: March 31, 2006Date of Patent: October 19, 2010Assignees: PhysioSonics, Inc., University of WashingtonInventors: Pierre D. Mourad, Michel Kliot, Rex Patterson, Alec Rooke
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Publication number: 20100087728Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 8, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Publication number: 20100081893Abstract: Methods and systems for identifying and spatially localizing tissues having certain physiological properties or producing certain biological responses, such as the sensation of pain, in response to the application of intense focused ultrasound (acoustic probing or palpation) are provided. In some embodiments, targeted acoustic probing may be guided or visualized using imaging techniques such as ultrasound imaging or other types of non-invasive imaging techniques.Type: ApplicationFiled: September 18, 2009Publication date: April 1, 2010Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Jeffrey G. JARVIK, Pierre D. MOURAD, Michel KLIOT, Robert C. A. FREDERICKSON
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Patent number: 7547283Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided, wherein a non-linear relationship is used to determine ICP based on one or more variable inputs. The first variable input relates to one or more properties of a cranial blood vessel and/or blood flow, such as acoustic backscatter from an acoustic transducer having a focus trained on a cranial blood vessel, flow velocity in a cranial blood vessel, and the like. Additional variables, such as arterial blood pressure (ABP), may be used in combination with a first variable input relating to one or more properties of a cranial blood vessel, such as flow velocity of the middle cerebral artery (MCA) to derive ICP using a non-linear relationship.Type: GrantFiled: June 3, 2004Date of Patent: June 16, 2009Assignee: PhysioSonics, Inc.Inventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C. A. Frederickson
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Publication number: 20090149751Abstract: Systems and methods for determining ICP based on parameters that can be measured using non-invasive or minimally invasive techniques are provided. Systems for acquiring acoustic data from a desired target site in a subject's body using various types of acoustic source and detector elements are also provided, including single use acoustic source/detector combinations are also provided. Acoustic arrays for use with these systems may include multiple capacitive micro-machined ultrasound transducer (cMUT) elements, and may include a combination of different types of acoustic arrays. Methods of targeting localized sites within a broad target area based on acoustic data having various properties are also disclosed.Type: ApplicationFiled: December 1, 2008Publication date: June 11, 2009Applicants: PHYSIOSONICS, INC., UNIVERSITY OF WASHINGTONInventors: Pierre D. Mourad, Brandt Mohr, Michel Kliot, Robert C.A. Frederickson, R. Lee Thompson, Jason L. Seawall
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Patent number: 7534209Abstract: Provided herein is a method for use in medical applications that permits affordable three-dimensional imaging of blood flow using a low-profile easily-attached transducer pad, real-time blood-flow vector velocity, and long-term unattended Doppler-ultrasound monitoring in spite of motion of the patient or pad. The pad and associated processor collects and Doppler processes ultrasound blood velocity data in a three dimensional region through the use of a planar phased array of piezoelectric elements. The invention locks onto and tracks the points in three-dimensional space that produce the locally maximum blood velocity signals. The integrated coordinates of points acquired by the accurate tracking process is used to form a three-dimensional map of blood vessels and provide a display that can be used to select multiple points of interest for expanded data collection and for long term continuous and unattended blood flow monitoring.Type: GrantFiled: December 20, 2002Date of Patent: May 19, 2009Assignee: PhysioSonics, Inc.Inventors: Kenneth Abend, Elsayed Hesham Attia
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Publication number: 20080269609Abstract: Provided herein is a method for use in medical applications that permits (1) affordable three-dimensional imaging of blood flow using a low-profile easily-attached transducer pad, (2) real-time blood-flow vector velocity, and (3) long-term unattended Doppler-ultrasound monitoring in spite of motion of the patient or pad. The pad and associated processor collects and Doppler processes ultrasound blood velocity data in a three dimensional region through the use of a planar phased array of piezoelectric elements. The invention locks onto and tracks the points in three-dimensional space that produce the locally maximum blood velocity signals. The integrated coordinates of points acquired by the accurate tracking process is used to form a three-dimensional map of blood vessels and provide a display that can be used to select multiple points of interest for expanded data collection and for long term continuous and unattended blood flow monitoring.Type: ApplicationFiled: July 10, 2008Publication date: October 30, 2008Applicant: PhysioSonics, Inc.Inventors: Kenneth Abend, Elsayed H. Attia
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Patent number: 7399279Abstract: Provided herein is a method for use in medical applications that permits (1) affordable three-dimensional imaging of blood flow using a low-profile easily-attached transducer pad, (2) real-time blood-flow vector velocity, and (3) long-term unattended Doppler-ultrasound monitoring in spite of motion of the patient or pad. The pad and associated processor collects and Doppler processes ultrasound blood velocity data in a three dimensional region through the use of a planar phased array of piezoelectric elements. The invention locks onto and tracks the points in three-dimensional space that produce the locally maximum blood velocity signals. The integrated coordinates of points acquired by the accurate tracking process is used to form a three-dimensional map of blood vessels and provide a display that can be used to select multiple points of interest for expanded data collection and for long term continuous and unattended blood flow monitoring.Type: GrantFiled: April 23, 2004Date of Patent: July 15, 2008Assignee: Physiosonics, IncInventors: Kenneth Abend, Elsayed H. Attia