Patents Assigned to Piramal Healthcare Limited
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Patent number: 8349862Abstract: The present invention provides novel compounds represented by the general formula (I): their stereoisomers, pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.Type: GrantFiled: August 31, 2011Date of Patent: January 8, 2013Assignee: Piramal Healthcare LimitedInventors: Nabajyoti Deka, Sivaramakrishnan Hariharan, Swapnil Ramesh Bajare, Rosalind Adaikalasamy Marita
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Patent number: 8304449Abstract: The present invention relates to novel compounds for the inhibition of cyclin-dependent kinases, and more particularly, to chromenone derivatives of formula (Ia), wherein R1, R2, R3, R4, R5, R6, R7 and A have the meanings indicated in the claims. The invention also relates to processes for the preparation of the compounds of formula (Ia), to methods of inhibiting cyclin-dependent kinases and of inhibiting cell proliferation, to the use of the compounds of formula (Ia) in the treatment and prophylaxis of diseases, which can be treated or prevented by the inhibition of cyclin-dependent kinases such as cancer, to the use of the compounds of formula (Ia) in the preparation of medicaments to be applied in such diseases.Type: GrantFiled: February 14, 2011Date of Patent: November 6, 2012Assignee: Piramal Healthcare LimitedInventors: Bansi Lal, Kalpana Joshi, Sanjeev Kulkarni, Malcolm Mascarenhas, Shrikant Kamble, Maggie Joyce Rathos, Rajendrakumar Joshi
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Patent number: 8269010Abstract: The present invention provides novel compounds represented by the general formula (I): their pharmaceutically acceptable salts and their pharmaceutically acceptable solvates thereof, which are useful in treating metabolic disorders related to insulin resistance or hyperglycemia. The invention also relates to a process for the manufacture of compounds of formula (I) and pharmaceutical compositions containing them.Type: GrantFiled: September 20, 2007Date of Patent: September 18, 2012Assignee: Piramal Healthcare LimitedInventors: Nabajyoti Deka, Kamlesh Jyotindra Padiya, Swapnil Ramesh Bajare, Rhushikesh Arun Kulkarni, Taj Usman Khan, Sivaramakrishnan Hariharan, Rosalind Adaikalasamy Marita
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Patent number: 8263579Abstract: This invention relates to novel compounds obtained by fermentation of Myxobacteria strain (PM0670013/MTCC 5570). The present invention further relates to the processes for the production of the novel anti-inflammatory compounds, to the culture no. PM0670013 (MTCC 5570), and to pharmaceutical compositions containing compounds of the present invention as an active ingredient and its use in medicines for the treatment of inflammatory diseases or disorders mediated by proinflammatory cytokines such as Tumor Necrosis Factor-alpha (TNF-?) and/or interleukins such as IL-6, having anti-inflammatory activity The invention also includes all stereoisomeric forms of compounds of the present invention.Type: GrantFiled: January 24, 2011Date of Patent: September 11, 2012Assignee: Piramal Healthcare LimitedInventors: Koteppa Pari, Girish Badrinath Mahajan, Nidhi Tomar, Vijaya Phani Kumar Yemparala, Asha Adrian Kulkarni-Almeida, Saji George
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Patent number: 8263587Abstract: The invention provides a novel benzoxazepine compound of the general formula (I): wherein R1 and R2 are as defined in the specification; or a stereoisomer, a geometric isomer, a pharmaceutically acceptable salt, a pharmaceutically acceptable solvate, or a polymorph thereof; a process for its preparation; and a pharmaceutical composition including an effective amount of the compound. The compounds are useful in the treatment of insulin resistance and clinical conditions associated therewith.Type: GrantFiled: November 1, 2007Date of Patent: September 11, 2012Assignee: Piramal Healthcare LimitedInventors: Swati Bal-Tembe, Bansi Lal, Satish Namdeo Sawant, Anagha Suhas Kulkarni
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Publication number: 20100185020Abstract: The present invention provides a continuous process for the production of 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) which comprises feeding continuously optimum molar quantities of 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether (CF3CHClOCHF2, Isoflurane) and anhydrous hydrogen fluoride, in a reactor in the vapour phase over a fluorination catalyst system comprising a metal pentahalide absorbed on a supporting substrate at a temperature ranging from 100° C. to 180° C., and separating 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) continuously from the reactor. The process of the present invention enables continuous removal of desflurane product thereby minimizing co-production of byproducts and resulting in high conversion efficiency and yield of desflurane.Type: ApplicationFiled: July 11, 2008Publication date: July 22, 2010Applicant: Piramal Healthcare LimitedInventors: Sivaramakrishnan Hariharan, Owen Chambers, Abhay Atmaram Upare, Damodharan Satagopan
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Publication number: 20090247751Abstract: A process for the preparation of N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethyl acetamide of formula II, comprising reacting a compound N-[3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl]acetamide of formula III, with an ethylating agent in the presence of a strong alkali metal hydroxide and a phase transfer catalyst in a polar-aprotic solvent, and a process for preparation of Zaleplon, which is substantially free of impurities using the said compound of formula II.Type: ApplicationFiled: February 13, 2007Publication date: October 1, 2009Applicant: PIRAMAL HEALTHCARE LIMITEDInventors: Vilas Vasant Pandit, Rajesh Vinodrai Naik, Abhay Atmaram Upare, Rajmohan Shivraj Ubale