Patents Assigned to Pliva Hrvatska d.o.o.
  • Salts and solid state forms of plinabulin
    Patent number: 11434225
    Abstract: The present disclosure relates to Plinabulin solid state forms, Plinabulin salts including hydrochloride and solid state forms thereof, processes for preparation thereof and pharmaceutical compositions thereof.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: September 6, 2022
    Assignee: PLIVA HRVATSKA D.O.O.
    Inventors: Marisa Martinelli, Pavel Kolesa, Donato Motolese, Paolo Simone Tiseni
  • Crystalline polymorphs of bardoxolone methyl
    Patent number: 11427533
    Abstract: Disclosed are crystalline polymorphs of Bardoxolone methyl, and pharmaceutical compositions thereof.
    Type: Grant
    Filed: July 12, 2018
    Date of Patent: August 30, 2022
    Assignee: PLIVA HRVATSKA D.O.O.
    Inventors: Ivana Landeka, Helena Ceric
  • Processes and intermediates for the preparation of Pimavanserin
    Patent number: 10807953
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: May 28, 2019
    Date of Patent: October 20, 2020
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • Processes and intermediates for the preparation of Pimavanserin
    Patent number: 10343993
    Abstract: The present disclosure relates to novel, safe and efficient processes for the synthesis of Pimavanserin and salts thereof, as well as novel intermediates that can be used in these processes.
    Type: Grant
    Filed: March 2, 2016
    Date of Patent: July 9, 2019
    Assignee: Pliva Hrvatska d.o.o.
    Inventors: Tomislav Biljan, Jasna Dogan, Leonid Metsger, Sara Morasi Pipercic, Marina Ratkaj, Maja Matanovic Skugor, Yi Wang
  • Crystal forms of O-desmethylvenlafaxine fumarate
    Patent number: 8569371
    Abstract: Provided are crystalline forms of O-desmethylvenlafaxine fumarate, methods for their preparation, and pharmaceutical composition thereof.
    Type: Grant
    Filed: March 29, 2011
    Date of Patent: October 29, 2013
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Marina Ratkaj, Gustavo Frenkel
  • Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
    Patent number: 8372822
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: February 12, 2013
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Edislav Leksic, Helena Ceric, Tina Mundorfer, Irena Zrinski Antonac, Zrinka Mastelic Samardzic
  • POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20120238612
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Application
    Filed: June 1, 2012
    Publication date: September 20, 2012
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Edislav LEKSIC, Helena CERIC, Tina MUNDORFER, Irena Zrinski ANTONAC, Zrinka Mastelic SAMARDZIC
  • Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
    Patent number: 8217021
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: July 10, 2012
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Edislav Leksic, Helena Ceric, Tina Mundorfer, Irena Zrinski Antonac, Zrinka Mastelic Samardzic
  • PHARMACEUTICALLY ACCEPTABLE SALT AND POLYMORPHIC FORMS OF FLUPIRTINE MALEATE
    Publication number: 20120142743
    Abstract: New polymorphic forms of flupirtine maleate are described.
    Type: Application
    Filed: February 9, 2012
    Publication date: June 7, 2012
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Aleksandar DANILOVSKI, Maja DEVCIC, Marina MARINKOVIC, Ernest MESTROVIC, Tina MUNDORFER, Iva TUNJIC
  • Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate
    Patent number: 8138349
    Abstract: The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical compositions containing them, therapeutic uses thereof and methods of treatment employing them.
    Type: Grant
    Filed: July 13, 2007
    Date of Patent: March 20, 2012
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Aleksandar Danilovski, Maja Dev{hacek over (c)}ić, Marina Marinković, Ernest Me{hacek over (s)}trović, Tina Mundorfer, Iva Tunjić
  • POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20120022124
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Application
    Filed: August 4, 2011
    Publication date: January 26, 2012
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Edislav LEKSIC, Helena CERIC, Tina MUNDORFER, Irena Zrinski ANTONAC, Zrinka Mastelic SAMARDZIC
  • Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
    Patent number: 8022093
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Grant
    Filed: April 19, 2011
    Date of Patent: September 20, 2011
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Edislav Leksic, Helena Ceric, Tina Mundorfer, Irena Zrinski Antonac, Zrinka Mastelic Samardzic
  • POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20110196008
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Application
    Filed: April 19, 2011
    Publication date: August 11, 2011
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Edislav LEKSIC, Helena CERIC, Tina MUNDORFER, Irena Zrinski ANTONAC, Zrinka Mastelic SAMARDZIC
  • Pharmaceutically acceptable salt and polymorphic forms of flupirtine maleate
    Publication number: 20110184030
    Abstract: The present invention is concerned with new polymorphic forms of flupirtine maleate, processes for preparing the new polymorphic forms, pharmaceutical compositions containing them, therapeutic uses thereof and methods of treatment employing them.
    Type: Application
    Filed: July 13, 2007
    Publication date: July 28, 2011
    Applicant: PLIVA Hrvatska d.o.o
    Inventors: Aleksandar Danilovski, Maja Devcic, Marina Marinkovic, Ernest Mestrovic, Tina Mundorfer, Iva Tunjic
  • SOLID STATE FORMS OF FOSAMPRENAVIR CALCIUM SALT AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20110165202
    Abstract: The present invention relates to solid state forms of fosamprenavir calcium salt, process for preparing said solid state forms, and pharmaceutical compositions thereof.
    Type: Application
    Filed: January 6, 2011
    Publication date: July 7, 2011
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Edislav LEKSIC, Dragan SEPAC, Dubravka PAVLICIC
  • Polymorphs of eltrombopag and eltrombopag salts and processes for preparation thereof
    Patent number: 7956048
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: June 7, 2011
    Assignee: Pliva Hrvatska D.O.O.
    Inventors: Edislav Leksic, Helena Ceric, Tina Mundorfer, Irena Zrinski Antonac, Zrinka Mastelic Samardzic
  • POLYMORPHS OF ELTROMBOPAG AND ELTROMBOPAG SALTS AND PROCESSES FOR PREPARATION THEREOF
    Publication number: 20100256212
    Abstract: New polymorphs of Eltrombopag and Eltrombopag ethanolamine salt have been obtained and characterized. These polymorphs and pharmaceutical compositions comprising them are useful, for example, in treating conditions leading to thrombocytopenia.
    Type: Application
    Filed: April 1, 2010
    Publication date: October 7, 2010
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Edislav LEKSIC, Helena CERIC, Tina MUNDORFER, Irena Zrinski ANTONAC, Zrinka Mastelic SAMARDZIC
  • PROCESS FOR PREPARING (R)-N-BENZYL-2-(BENYLOXYCARBONYLAMINO)-3-METHOXYPROPIONAMIDE
    Publication number: 20100240926
    Abstract: (R)—N-benzyl-2-(benzyloxycarbonylamino)-3-methoxypropionamide is an intermediate useful for preparing lacosamide. It can be prepared, for example, by combining (R)—N-benzyl-2-(benzyloxycarbonylamino)-3-hydroxypropionamide with dimethylsulfate, followed by mixing with an alkali or alkaline earth metal hydroxide at a temperature of about 25° C. to about ?15° C.
    Type: Application
    Filed: March 18, 2010
    Publication date: September 23, 2010
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Gordana VRBANEC, Miroslava HARCA, Ana SUCEC, Damir SAHNIC, Amir AVDAGIC
  • Pharmaceutical Formulation Comprising Donepezil
    Publication number: 20100055171
    Abstract: The present invention relates to a pharmaceutical composition comprising 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one, herein after referred to as Donepezil, or a pharmaceutically acceptable salt thereof, for treating of Alzheimer's disease and senile dementia. The present invention also relates to a manufacturing process for the preparation of Donepezil tablets containing and retaining polymorphic Form I of Donepezil hydrochloride. This composition also discloses the use of the excipients that ensure adequate flowability of a dry blend as well as required content uniformity and drug release rate of the final product.
    Type: Application
    Filed: June 29, 2007
    Publication date: March 4, 2010
    Applicant: PLIVA Hrvatska d.o.o.
    Inventors: Violeta Cindric, Ivica Grebenar, Snjezana Miric, Maja Devcic
  • POLYMORPHIC AND AMORPHOUS FORMS OF LACOSAMIDE AND AMORPHOUS COMPOSITIONS
    Publication number: 20090298947
    Abstract: The present invention relates to polymorphic and amorphous forms of Lacosamide, processes of preparing the polymorphic and amorphous forms, pharmaceutical compositions containing the same, therapeutic uses thereof and methods of treatment employing the same.
    Type: Application
    Filed: May 27, 2009
    Publication date: December 3, 2009
    Applicant: PLIVA HRVATSKA D.O.O.
    Inventors: Tina MUNDORFER, Marina MARKOVIC, Nada KOSUTIC HULITA, Miroslav ZEGARAC